INT56651

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Context Info
Confidence 0.48
First Reported 1993
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 58
Total Number 61
Disease Relevance 52.25
Pain Relevance 13.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
T-cell 4
plasma 1
dendritic cells 1
telomere 1
blood 1
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 724 100.00 Very High Very High Very High
Multiple sclerosis 451 100.00 Very High Very High Very High
spinal inflammation 36 100.00 Very High Very High Very High
Chronic pancreatitis 5 99.28 Very High Very High Very High
Inflammation 233 99.08 Very High Very High Very High
Osteoarthritis 124 98.80 Very High Very High Very High
cINOD 18 98.28 Very High Very High Very High
cytokine 171 98.02 Very High Very High Very High
Arthritis 121 97.22 Very High Very High Very High
postherpetic neuralgia 8 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 1011 100.00 Very High Very High Very High
Rheumatoid Arthritis 777 100.00 Very High Very High Very High
Demyelinating Disease 386 100.00 Very High Very High Very High
Multiple Sclerosis 101 100.00 Very High Very High Very High
Low Back Pain 26 100.00 Very High Very High Very High
Sleep Disorders 8 100.00 Very High Very High Very High
Malignant Neoplastic Disease 13 99.96 Very High Very High Very High
Autoimmune Disease 125 99.84 Very High Very High Very High
Giant Cell Arteritis 156 99.82 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 83 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Out of the HLA-DRB1 *04 subtypes, HLA-DRB1 *0405 had the strongest association with the VKH disease [11].
HLA-DRB1 Binding (association) of associated with disease
1) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 1.77 Pain Relevance 0
However, most of the reports on the association of HLA-DRB1 with Kawasaki disease concluded that despite a regional association, their data failed to support a consistent role for HLA class II alleles in Kawasaki disease.
HLA-DRB1 Binding (association) of associated with mucocutaneous lymph node syndrome
2) Confidence 0.42 Published 2007 Journal Pediatr Cardiol Section Body Doc Link PMC2267487 Disease Relevance 1.07 Pain Relevance 0
Association of HLA-DRB1*0401 allele with chronic pancreatitis.
DRB1 Binding (Association) of associated with chronic pancreatitis
3) Confidence 0.42 Published 2003 Journal Pancreas Section Title Doc Link 12717273 Disease Relevance 0.29 Pain Relevance 0.29
These studies imply direct interactions between HLA-DRB1, the main susceptibility locus for MS, and vitamin D, a strong candidate for mediating the environmental effect.
DRB1 Binding (interactions) of associated with multiple sclerosis
4) Confidence 0.41 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.44 Pain Relevance 0.13
The data presented here confirmed an association of HLA-DRB1 *0405 with the VKH patients in Saudi Arabia.
HLA-DRB1 Binding (association) of associated with disease
5) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 1.66 Pain Relevance 0
Out of the HLA-DRB1 *04 subtypes, HLA-DRB1 *0405 had the strongest association with the VKH disease [11].
HLA-DRB1 Binding (association) of associated with disease
6) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 1.78 Pain Relevance 0
HLA-DRB1 genotyping
HLA-DRB1 Binding (genotyping) of
7) Confidence 0.37 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2577639 Disease Relevance 0 Pain Relevance 0.03
RA has been associated with the SE of HLA-DRB1, which includes DRB1*04 and DRB1*01 alleles [19].
HLA-DRB1 Binding (associated) of associated with rheumatoid arthritis
8) Confidence 0.37 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2577639 Disease Relevance 0.48 Pain Relevance 0.16
HLA DRB1*0405-DQB1*0401 alleles are significantly associated with autoimmune pancreatitis, and may present a specific peptide which triggers the autoimmune response.
DRB1 Binding (associated) of associated with pancreatitis
9) Confidence 0.36 Published 2007 Journal J. Gastroenterol. Section Abstract Doc Link 17520217 Disease Relevance 1.50 Pain Relevance 0.33
To assess the significance of the association of HLA-DRB1 *0405 alleles and the VKH disease, the association of HLA-DRB1 *0405 with complete VKH and incomplete VKH was analyzed.
HLA-DRB1 Binding (association) of associated with disease
10) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 0.20 Pain Relevance 0
This was the only VDRE we found and strikingly it shows haplotype-specific differences, being highly conserved in the major MS associated haplotype HLA-DRB1*15 dominant in Northern European populations, but not conserved among non-MS associated haplotypes.
HLA-DRB1*15 Binding (associated) of associated with multiple sclerosis
11) Confidence 0.35 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.57 Pain Relevance 0.20
Among the most prominent associations are narcolepsy with HLA-DQB1*0602/HLA-DRB1*1501, ankylosing spondylitis with HLA-B27, and celiac disease with HLA-DQB1*02.
DRB1 Binding (narcolepsy) of associated with spinal inflammation, celiac disease and sleep disorders
12) Confidence 0.35 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 1.39 Pain Relevance 0.14
Moreover, the homologous segments contain the binding motif of the HLA molecule DRB1*0405.
DRB1 Binding (binding) of
13) Confidence 0.35 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202223 Disease Relevance 0.84 Pain Relevance 0.07
Association of HLA-DR11 with the anaphylactoid reaction caused by nonsteroidal anti-inflammatory drugs.
HLA-DR11 Binding (Association) of associated with inflammation, anaphylaxis and cinod
14) Confidence 0.35 Published 1999 Journal J. Allergy Clin. Immunol. Section Title Doc Link 10200020 Disease Relevance 0.39 Pain Relevance 0.38
The VDR bound DNA fragments were then recovered after reversal of protein-DNA crosslinking and analysed by PCR using primers specific for the HLA-DRB1 promoter.
DRB1 Spec (analysed) Binding (crosslinking) of
15) Confidence 0.32 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0 Pain Relevance 0
It was found that vitamin D specifically interacts with HLA-DRB1*1501 to influence its expression.
DRB1 Binding (interacts) of
16) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2627899 Disease Relevance 0.98 Pain Relevance 0.23
Juvenile arthritis (JA) is a term that covers a number of different disease entities, of which only three present with significant Human Leukocyte Antigen (HLA) associations. (1) Pauciarticular JA with late onset and a strong male proponderance is associated with HLA-B27 and represents the group of juvenile spondyloarthropathies related to adult ankylosing spondylitis. (2) Early onset pauciarticular JA with a preponderance of females and a frequent occurance of chronic iridocyclitis and the frequent presence of anti-nuclear antibodies is associated with alleles from three different regions of the HLA system: HLA-A2, which shows a very strong correlation with early age of onset; DR8, DR11 and DR12 as well as DQA1*0401, *0501, *0601 and finally DPB1*0201.
DR8 Binding (associated) of in Juvenile associated with iridocyclitis, spinal inflammation, disease and arthritis
17) Confidence 0.30 Published 1998 Journal Baillieres Clin Rheumatol Section Abstract Doc Link 9890094 Disease Relevance 0.96 Pain Relevance 0.43
In addition, autism has been linked with autoimmunity and an association with immune-based genes including human leukocyte antigen (HLA)-DRB1 and complement C4 alleles described.
DRB1 Binding (association) of in leukocyte associated with autoimmune disease and autism
18) Confidence 0.29 Published 2006 Journal J. Leukoc. Biol. Section Abstract Doc Link 16698940 Disease Relevance 0.49 Pain Relevance 0.13
In northwestern Spain, in contrast, where susceptibility to GCA has been associated with HLA-DRB1*04 [4], no evidence was found of an interaction between HLA-DRB1*04 and polymorphisms of ICAM-1.
HLA-DRB1 Binding (interaction) of associated with giant cell arteritis
19) Confidence 0.28 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.01 Pain Relevance 0.17
Most studies have shown an association with HLA-DRB1*04 alleles [4].
HLA-DRB1 Binding (association) of
20) Confidence 0.28 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 2.15 Pain Relevance 0.07

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