INT56656

Context Info Confidence 0.49 First Reported 1993 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.09 Pain Relevance 1.92

cytoplasm (Spnb4)

Spnb4 (Mus musculus)

Pain Link Frequency Relevance Heat Dynorphin 3 99.36 neuropeptide release 3 98.56 narcan 2 97.62 antagonist 5 97.44 Opioid 4 97.20 Morphine 5 96.64 Eae 18 96.04 tail-flick 1 88.24 nalbuphine 2 86.40 Neurotransmitter 1 85.68

Disease Link Frequency Relevance Heat Disease 102 100.00 Ataxia 9 71.48 Cerebellar Diseases 1 66.20 Dystonia 48 61.16 Syndrome 8 53.64 Anaerobic Bacterial Infections 1 39.04 Hyperuricemia 19 16.92 Cognitive Disorder 36 13.40 Congenital Anomalies 18 5.00 Injury 13 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Additional pharmacological tests were used as criteria for Dyn A release: a) Small doses of the opioid antagonists naloxone and norbinaltorphimine administered IT inhibited the antagonistic action; b) dynorphin antiserum given IT blocked the action of Dyn A; c) desensitization to the effect of Dyn A was produced by 3-h pretreatment with morphine, 10 mg/kg SC, or by pretreatment with the agents themselves.

Positive_regulation (action) of Dyn associated with dynorphin, antagonist, narcan, opioid and morphine

1) Confidence 0.49 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8101007 Disease Relevance 0 Pain Relevance 1.70

LND and its variants are caused by different mutations in the HPRT gene (Table 6).

Positive_regulation (caused) of LND associated with disease

2) Confidence 0.31 Published 2010 Journal Brain Section Body Doc Link PMC2842514 Disease Relevance 1.09 Pain Relevance 0

This suggests that Shaw-dependent changes in the LNd and DNs are responsible for rhythmic accumulation of PDF, which in turn may mediate changes in LD locomotor activity.

Positive_regulation (changes) of LNd associated with eae

3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.21

General Comments

This test has worked.