INT56656

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.09
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Spnb4)
Spnb4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 3 99.36 Very High Very High Very High
neuropeptide release 3 98.56 Very High Very High Very High
narcan 2 97.62 Very High Very High Very High
antagonist 5 97.44 Very High Very High Very High
Opioid 4 97.20 Very High Very High Very High
Morphine 5 96.64 Very High Very High Very High
Eae 18 96.04 Very High Very High Very High
tail-flick 1 88.24 High High
nalbuphine 2 86.40 High High
Neurotransmitter 1 85.68 High High
Disease Link Frequency Relevance Heat
Disease 102 100.00 Very High Very High Very High
Ataxia 9 71.48 Quite High
Cerebellar Diseases 1 66.20 Quite High
Dystonia 48 61.16 Quite High
Syndrome 8 53.64 Quite High
Anaerobic Bacterial Infections 1 39.04 Quite Low
Hyperuricemia 19 16.92 Low Low
Cognitive Disorder 36 13.40 Low Low
Congenital Anomalies 18 5.00 Very Low Very Low Very Low
Injury 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional pharmacological tests were used as criteria for Dyn A release: a) Small doses of the opioid antagonists naloxone and norbinaltorphimine administered IT inhibited the antagonistic action; b) dynorphin antiserum given IT blocked the action of Dyn A; c) desensitization to the effect of Dyn A was produced by 3-h pretreatment with morphine, 10 mg/kg SC, or by pretreatment with the agents themselves.
Positive_regulation (action) of Dyn associated with dynorphin, antagonist, narcan, opioid and morphine
1) Confidence 0.49 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8101007 Disease Relevance 0 Pain Relevance 1.70
LND and its variants are caused by different mutations in the HPRT gene (Table 6).
Positive_regulation (caused) of LND associated with disease
2) Confidence 0.31 Published 2010 Journal Brain Section Body Doc Link PMC2842514 Disease Relevance 1.09 Pain Relevance 0
This suggests that Shaw-dependent changes in the LNd and DNs are responsible for rhythmic accumulation of PDF, which in turn may mediate changes in LD locomotor activity.
Positive_regulation (changes) of LNd associated with eae
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.21

General Comments

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