INT5674

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Context Info
Confidence 0.77
First Reported 1986
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 6.14
Pain Relevance 15.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
embryonic stem cells 2
neurons 2
frontal cortex 2
macrophages 1
saphenous vein 1
Adra2a (Mus musculus)
Adra2a - D79N (3) Adra2a - T370K (1)
Pain Link Frequency Relevance Heat
agonist 63 100.00 Very High Very High Very High
Clonidine 39 100.00 Very High Very High Very High
antinociception 15 100.00 Very High Very High Very High
antidepressant 7 100.00 Very High Very High Very High
tolerance 2 100.00 Very High Very High Very High
opiate 14 99.64 Very High Very High Very High
Dopamine 1 99.62 Very High Very High Very High
antagonist 29 99.40 Very High Very High Very High
Intractable pain 1 99.30 Very High Very High Very High
Desipramine 5 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 100.00 Very High Very High Very High
Myocardial Infarction 3 99.74 Very High Very High Very High
Intractable Pain 1 99.30 Very High Very High Very High
Sprains And Strains 4 99.06 Very High Very High Very High
Cancer 1 98.64 Very High Very High Very High
Aggression 4 96.36 Very High Very High Very High
Low Back Pain 1 95.64 Very High Very High Very High
Hypertrophy 1 95.28 Very High Very High Very High
Shock 1 94.92 High High
Suicidal Behaviour 16 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lack of alpha2C-AR expression was associated with increased amphetamine-induced locomotor activity, startle reactivity, aggression, and activity in the forced swimming test; prepulse inhibition of the startle reflex was attenuated.
Gene_expression (expression) of alpha2C-AR associated with eae and aggression
1) Confidence 0.77 Published 2001 Journal Life Sci. Section Abstract Doc Link 11358337 Disease Relevance 0.43 Pain Relevance 0.17
This pharmacodynamic response is consistent with previous anatomical observations that alpha2A ARs are expressed on primary afferent neurons and macrophages near injured tissue.
Gene_expression (expressed) of alpha2A in macrophages
2) Confidence 0.76 Published 2005 Journal Pain Section Abstract Doc Link 15911163 Disease Relevance 0.07 Pain Relevance 0.84
We report here the transfection, selection and preliminary pharmacological characterization of two mammalian cell lines, adherent Shionogi S115 mouse mammary tumour cells and human B-lymphoblastoid IBW4 cells growing in suspension, expressing the human alpha 2-AR subtypes alpha 2-C4 and alpha 2-C10 at densities of approx. 2 x 10(5) receptors/cell.
Gene_expression (expressing) of alpha 2-C10 associated with cancer
3) Confidence 0.75 Published 1992 Journal Biochim. Biophys. Acta Section Abstract Doc Link 1313304 Disease Relevance 0.10 Pain Relevance 0.14
The expression of alpha2A-adrenoceptors is sufficient to promote delta opiate receptor-mediated neurite outgrowth, suggesting that the presence of inactive alpha2A-adrenoceptors can enhance delta opiate receptor-mediated signalling. 5.
Gene_expression (expression) of alpha2A-adrenoceptors in neurite associated with opiate
4) Confidence 0.72 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.87
Lack of alpha2C-AR expression was associated with increased amphetamine-induced locomotor activity, startle reactivity, aggression, and activity in the forced swimming test; prepulse inhibition of the startle reflex was attenuated.
Gene_expression (expression) of alpha2C-AR associated with eae and aggression
5) Confidence 0.67 Published 2001 Journal Life Sci. Section Abstract Doc Link 11358337 Disease Relevance 0.43 Pain Relevance 0.17
Prazosin did not block clonidine-stimulated NaCl uptake or efflux, indicating the presence of an alpha 2A-AR subtype.
Gene_expression (presence) of alpha 2A-AR associated with clonidine
6) Confidence 0.66 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8096363 Disease Relevance 0 Pain Relevance 0.72
Membrane assays with the antagonist [3H]RX821002 (2-[3H]methoxyidazoxan) suggested the presence of alpha2A-adrenoceptors in the frontal cortex and both alpha2C-adrenoceptors and alpha2A-adrenoceptors in the caudate.
Gene_expression (presence) of alpha2A-adrenoceptors in frontal cortex associated with antagonist and urological neuroanatomy
7) Confidence 0.66 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489732 Disease Relevance 0.80 Pain Relevance 0.17
Results demonstrate that alpha2A/D-autoreceptors operate already at P1 whereas nonalpha2A/D-autoreceptors, presumably alpha2C, develop later.
Gene_expression (operate) of alpha2A
8) Confidence 0.65 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11683524 Disease Relevance 0 Pain Relevance 0.57
The studies employed two genetically engineered mouse strains, having either a targeted inactivation of the alpha2C-AR gene (alpha2C-KO) or over-expressing the alpha2C-AR (alpha2C-OE).
Gene_expression (expressing) of alpha2C-AR associated with sprains and strains
9) Confidence 0.60 Published 2001 Journal Life Sci. Section Abstract Doc Link 11358337 Disease Relevance 0.43 Pain Relevance 0.17
The studies employed two genetically engineered mouse strains, having either a targeted inactivation of the alpha2C-AR gene (alpha2C-KO) or over-expressing the alpha2C-AR (alpha2C-OE).
Gene_expression (expressing) of alpha2C-AR associated with sprains and strains
10) Confidence 0.60 Published 2001 Journal Life Sci. Section Abstract Doc Link 11358337 Disease Relevance 0.43 Pain Relevance 0.17
These findings support the notion that clonidine produces sympathoinhibition through multiple sites within the medullary reticular formation, which is consistent with the wide distribution of the alpha2A-AR in reticulospinal neurons.
Gene_expression (distribution) of alpha2A-AR in neurons associated with clonidine
11) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215641 Disease Relevance 0.09 Pain Relevance 0.86
Spinal implantation of catecholamine-releasing cells may provide an alternative approach for the therapy of chronic intractable pain and a useful model to study alpha 2-adrenergic receptor tolerance.
Gene_expression (tolerance) of 2-adrenergic in Spinal associated with intractable pain, catecholamine and tolerance
12) Confidence 0.58 Published 1994 Journal Pain Section Abstract Doc Link 7516533 Disease Relevance 0.23 Pain Relevance 1.07
Membrane assays with the antagonist [3H]RX821002 (2-[3H]methoxyidazoxan) suggested the presence of alpha2A-adrenoceptors in the frontal cortex and both alpha2C-adrenoceptors and alpha2A-adrenoceptors in the caudate.
Gene_expression (presence) of alpha2A-adrenoceptors in frontal cortex associated with antagonist and urological neuroanatomy
13) Confidence 0.58 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489732 Disease Relevance 0.83 Pain Relevance 0.17
Clonidine produced antinociception in WT but not D79N-alpha2a mice.
Gene_expression (produced) of D79N-alpha2a (D79N) associated with antinociception and clonidine
14) Confidence 0.57 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10381806 Disease Relevance 0.14 Pain Relevance 1.34
Null mice for each of the three alpha2-adrenoceptor subtypes (alpha2A, alpha2B, and alpha2C) and their wild-type cohorts were tested for their antinociceptive response to isoflurane.
Gene_expression (each) of alpha2A
15) Confidence 0.55 Published 2002 Journal Anesthesiology Section Body Doc Link 11818770 Disease Relevance 0 Pain Relevance 0
The biochemical exploration of the alpha 2-adrenergic receptors was investigated in the canine saphenous vein using the highly selective alpha 2-adrenergic antagonist rauwolscine as a tritiated ligand.
Spec (investigated) Gene_expression (exploration) of 2-adrenergic in saphenous vein associated with antagonist
16) Confidence 0.53 Published 1988 Journal Life Sci. Section Abstract Doc Link 2850417 Disease Relevance 0 Pain Relevance 0.05
Similar conclusions could be made on enhancement of the ligands' intrinsic activities by coexpression of the mutant Thr370Lys alpha2B AR with either a Galpha15 or Galphao Cys351Ile protein.
Gene_expression (coexpression) of alpha2B AR (T370K)
17) Confidence 0.44 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617142 Disease Relevance 0 Pain Relevance 0.25
We therefore exploited a genetically modified mouse line expressing a point mutation (D79N) in the alpha2a adrenergic receptor (alpha2aAR) to investigate the role of the alpha2aAR in alpha2 agonist-evoked analgesia and adrenergic-opioid synergy.
Gene_expression (expressing) of alpha2aAR associated with agonist, opioid and analgesia
18) Confidence 0.38 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9278550 Disease Relevance 0 Pain Relevance 1.52
In addition, 5,7-DHT lesioning prevented the adaptive attenuation of this alpha 2-adrenoceptor-mediated response produced by daily injection of desipramine (10 mg/kg) for 14 days, but had no effect on the reduction caused by five electroconvulsive shocks (ECS, 200 V, 2 s) spread over 10 days.
Gene_expression (produced) of alpha 2-adrenoceptor-mediated associated with desipramine and shock
19) Confidence 0.36 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2160663 Disease Relevance 0.17 Pain Relevance 0.45
Additionally, sedative/ hypnotic effects of etomidate (8 mg/kg IP) were studied by rotarod test in wild-type (WT) mice and mice carrying targeted deletions of the alpha2A-adrenoceptor gene (alpha2A-KO).
Gene_expression (deletions) of alpha2A-adrenoceptor
20) Confidence 0.35 Published 2007 Journal Anesth. Analg. Section Body Doc Link 18042862 Disease Relevance 0 Pain Relevance 0

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