INT56749

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Context Info
Confidence 0.77
First Reported 1993
Last Reported 2010
Negated 7
Speculated 12
Reported most in Abstract
Documents 219
Total Number 232
Disease Relevance 111.25
Pain Relevance 18.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
Anatomy Link Frequency
HGF 6
epithelial cells 5
liver 4
chondrocytes 3
gingiva 3
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 89 100.00 Very High Very High Very High
Paracetamol 54 99.82 Very High Very High Very High
methotrexate 192 99.72 Very High Very High Very High
rheumatoid arthritis 172 99.66 Very High Very High Very High
qutenza 525 99.28 Very High Very High Very High
aspirin 337 99.12 Very High Very High Very High
Angina 16 98.92 Very High Very High Very High
narcan 3 98.32 Very High Very High Very High
COX-2 inhibitor 70 98.28 Very High Very High Very High
Bile 36 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1527 100.00 Very High Very High Very High
Metastasis 483 100.00 Very High Very High Very High
Pituitary Cancer 12 100.00 Very High Very High Very High
Hepatocellular Cancer 474 99.98 Very High Very High Very High
Ulcers 298 99.98 Very High Very High Very High
Aging 68 99.90 Very High Very High Very High
Metaplasia 270 99.86 Very High Very High Very High
Breast Cancer 693 99.84 Very High Very High Very High
Cleidocranial Dysplasia 333 99.84 Very High Very High Very High
Sleep Disorders 162 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: NCTD inhibits the proliferation of human gallbladder carcinoma GBC-SD cells in vitro and the expression of their proliferation-related gene proteins PCNA and Ki-67.


Gene_expression (expression) of PCNA
1) Confidence 0.77 Published 2004 Journal HBPD INT Section Body Doc Link 15567755 Disease Relevance 0.06 Pain Relevance 0
The levels of PCNA expression in coronary lesions were not associated with the subsequent development of restenosis after DCA.
Gene_expression (expression) of PCNA associated with cardiovascular disease
2) Confidence 0.76 Published 1997 Journal Hiroshima J. Med. Sci. Section Abstract Doc Link 9114565 Disease Relevance 1.32 Pain Relevance 0.53
In our study, we investigated the growth-inhibitory mechanism of a selective COX-2 inhibitor, NS-398, in 4 hepatocellular carcinoma cell lines by studying cell growth, COX-2 and proliferating cell nuclear antigen (PCNA) expression, cell cycle distribution and the evidence of apoptosis.
Gene_expression (expression) of proliferating cell nuclear antigen associated with hepatocellular cancer, cox-2 inhibitor and apoptosis
3) Confidence 0.75 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12115513 Disease Relevance 0.51 Pain Relevance 0.28
Significantly improved Child-Pugh scores were seen at 4 and 24 weeks (p < .05). alpha-Fetoprotein and proliferating cell nuclear antigen (PCNA) expression in liver biopsy tissue was significantly elevated after ABMI therapy (p < .05).
Gene_expression (expression) of proliferating cell nuclear antigen in liver
4) Confidence 0.75 Published 2006 Journal Stem Cells Section Abstract Doc Link 16778155 Disease Relevance 0.42 Pain Relevance 0.11
In addition, the serum from the HCAO patient significantly stimulated the MTT intensity, the level of proliferating cell nuclear antigen expression, a proliferation marker, and ALP activity in MC3T3-E1 cells, compared with that from the control subject.
Gene_expression (expression) of proliferating cell nuclear antigen in MC3T3-E1 associated with osteosclerosis
5) Confidence 0.75 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 17177144 Disease Relevance 1.48 Pain Relevance 0.08
Lansoprazole favors mucosal cell renewal simultaneously by stimulating gene expression of prosurvival proliferating cell nuclear antigen, survivin, epidermal growth factor, and basic fibroblast growth factor.
Gene_expression (expression) of proliferating cell nuclear antigen in fibroblast
6) Confidence 0.75 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18375387 Disease Relevance 0.69 Pain Relevance 0.22
Based on the results of animal studies in our laboratory, it appears that the mechanism of shock waves first stimulates the early expression of angiogenesis-related growth factors including eNOS (endothelial nitric oxide synthase), VEGF (vessel endothelial growth factor) and PCNA (proliferating cell nuclear antigen), then induces the ingrowth of neovascularization that improves blood supply and increases cell proliferation and eventual tissue regeneration to repair tendon or bone tissues.
Gene_expression (expression) of proliferating cell nuclear antigen in tendon associated with shock
7) Confidence 0.75 Published 2003 Journal Chang Gung Med J Section Abstract Doc Link 12846521 Disease Relevance 1.36 Pain Relevance 0.33
The immunohistochemical staining showed that there were strong expressions of bFGF and TGF-beta1 and their receptors, as well as a strong expression of proliferating cell nuclear antigen in the zones of granulation tissue in the painful discs.
Gene_expression (expression) of proliferating cell nuclear antigen in granulation
8) Confidence 0.75 Published 2006 Journal Spine Section Body Doc Link 16508552 Disease Relevance 0 Pain Relevance 0
Immunohistochemical analysis was used to define the different hormone types of the tumors and the expression of various immunologic targets, including the pituitary tumor transforming gene, basic fibroblast growth factor-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and proliferating cell nuclear antigen.
Gene_expression (expression) of proliferating cell nuclear antigen in pituitary associated with cancer, pituitary cancer and metalloproteinase
9) Confidence 0.75 Published 2009 Journal J Clin Neurosci Section Abstract Doc Link 19046883 Disease Relevance 1.13 Pain Relevance 0.18
Changes in the expression of proliferating cell nuclear antigen, Fas, progesterone receptor (PRA) and estrogen receptor alpha (ER-alpha) were analyzed by immunohistochemistry.
Gene_expression (expression) of proliferating cell nuclear antigen
10) Confidence 0.75 Published 2009 Journal Hum. Reprod. Section Body Doc Link 19661125 Disease Relevance 0.17 Pain Relevance 0
Fan induced p27 expression and inhibited cyclin D and proliferating cell nuclear antigen (PCNA) expression in PC3 cells.
Gene_expression (expression) of proliferating cell nuclear antigen
11) Confidence 0.75 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20208355 Disease Relevance 1.24 Pain Relevance 0.08
Proliferating cell nuclear antigen expression was enhanced, and interleukin-6 expression was reduced in the mice that received hrVEGF (p < 0.05) compared with the APAP/vehicle mice.
Gene_expression (expression) of Proliferating cell nuclear antigen associated with paracetamol
12) Confidence 0.75 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20363854 Disease Relevance 0.67 Pain Relevance 1.01
OBJECTIVES: To study and confirm the effect of indomethacin on the expression of Bfl-1, WISP-1 and PCNA in human colon cancer line HCT116 cells and the COX-2 independent tumor inhibiting pathway.
Gene_expression (expression) of PCNA in colon
13) Confidence 0.71 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.09 Pain Relevance 0
RESULTS: Indomethacin down-regulated the expression of Bfl-1, WISP-1 and PCNA mRNA in vitro (9.53 +/- 0.15 vs 27.87 +/- 0.12, 7.37 +/- 0.58 vs 20.17 +/- 0.58, 5.17 +/- 0.06 vs 0.87 +/- 0.06).
Gene_expression (expression) of PCNA mRNA
14) Confidence 0.71 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.07 Pain Relevance 0
The expression of Bfl-1, WISP-1 and PCNA, mRNA and protein were determined by a real-time quantitative PCR and Western blot, respectively.
Spec (determined) Gene_expression (expression) of PCNA
15) Confidence 0.71 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.08 Pain Relevance 0
Indomethacin also down-regulated the expression of Bfl-1, WISP-1 and PCNA protein (40.01 +/- 1.61 vs 43.76 +/- 1.63, 22.50 +/- 1.17 vs 30.30 +/- 1.55, 17.69 +/- 1.18 vs 20.80 +/- 1.08).
Gene_expression (expression) of PCNA protein
16) Confidence 0.71 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 17054584 Disease Relevance 0.07 Pain Relevance 0
In our study, we investigated the growth-inhibitory mechanism of a selective COX-2 inhibitor, NS-398, in 4 hepatocellular carcinoma cell lines by studying cell growth, COX-2 and proliferating cell nuclear antigen (PCNA) expression, cell cycle distribution and the evidence of apoptosis.
Gene_expression (expression) of PCNA associated with hepatocellular cancer, cox-2 inhibitor and apoptosis
17) Confidence 0.70 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12115513 Disease Relevance 0.51 Pain Relevance 0.28
PCNA expression was downregulated by NS-398 in a dose-independent manner.
Gene_expression (expression) of PCNA
18) Confidence 0.70 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12115513 Disease Relevance 0.56 Pain Relevance 0.27
Proliferating cell nuclear antigen (PCNA) expression in gastric epithelial cells was also determined.
Gene_expression (expression) of PCNA in epithelial cells
19) Confidence 0.67 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 16808793 Disease Relevance 0 Pain Relevance 0
The positivity rate of PCNA expression in the cancerous tissues was significantly higher than that in the non-cancerous tissues (80.0%vs 14.1%, P < 0.05).
Gene_expression (expression) of PCNA in 14.1
20) Confidence 0.67 Published 2006 Journal Chin J Dig Dis Section Body Doc Link 16808793 Disease Relevance 0 Pain Relevance 0

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