INT56768

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.91
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) endosome (Ntrk1) aging (Ntrk1)
plasma membrane (Ntrk1) cytoplasm (Ntrk1)
Anatomy Link Frequency
nerves 4
neurons 2
lamina 2
skin 2
Ntrk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 26 100.00 Very High Very High Very High
Trk A 14 100.00 Very High Very High Very High
Neurotransmitter 3 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Glutamate 1 100.00 Very High Very High Very High
primary afferent fibers 1 99.84 Very High Very High Very High
nociceptor 5 99.62 Very High Very High Very High
Eae 10 98.40 Very High Very High Very High
Inflammation 4 98.40 Very High Very High Very High
Calcitonin gene-related peptide 3 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 19 99.96 Very High Very High Very High
Hypersensitivity 1 99.40 Very High Very High Very High
Tooth Injuries 2 98.84 Very High Very High Very High
INFLAMMATION 4 98.40 Very High Very High Very High
Nociception 6 98.12 Very High Very High Very High
Demyelinating Disease 4 96.76 Very High Very High Very High
Mycobacterium Infection 9 92.28 High High
Ganglion Cysts 1 88.00 High High
Neuropathic Pain 1 73.88 Quite High
Pain 6 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Time course of the increase in trk A expression in trigeminal neurons after tooth injury.
Positive_regulation (increase) of Gene_expression (expression) of trk A in neurons associated with tooth injuries, nociceptor and trk a
1) Confidence 0.67 Published 2000 Journal J Endod Section Title Doc Link 11194379 Disease Relevance 0.78 Pain Relevance 0.76
These data further indicate that expression of nerve growth factor receptor by Schwann cells does not require axonal degeneration, but can be stimulated by some factor associated with acute demyelination.
Neg (not) Positive_regulation (require) of Gene_expression (expression) of nerve growth factor receptor in nerve associated with demyelination and nerve growth factor
2) Confidence 0.50 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.36 Pain Relevance 0.69
In this preparation, BDNF (100-500 ng/mL) enhances the release of sensory neurotransmitters (glutamate, substance P, CGRP) in lamina II by acting on trkB receptors expressed by primary afferent fibers of the peptidergic nociceptive type (PN-PAFs).
Positive_regulation (enhances) of Gene_expression (expressed) of trk in lamina associated with nociception, glutamate, neurotransmitter, primary afferent fibers and substance p
3) Confidence 0.49 Published 2008 Journal Dev Neurobiol Section Abstract Doc Link 18172890 Disease Relevance 0.19 Pain Relevance 0.50
CGRP-IR fibres almost disappeared at 2 weeks post-CCI, but quickly sprouted, leading to a significant peak above sham levels 4 weeks post-injury. trkA receptor expression was found to be up-regulated in small cutaneous nerves 4 weeks post-CCI, returning to sham levels by 8 weeks post-CCI.
Positive_regulation (up-regulated) of Gene_expression (expression) of trkA receptor in nerves associated with eae, injury and calcitonin gene-related peptide
4) Confidence 0.43 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15932605 Disease Relevance 1.41 Pain Relevance 0.79
Keratinocyte trk A expression (which mediates an autocrine role for NGF) was increased in clinically affected and unaffected skin, suggesting a compensatory mechanism secondary to reduced NGF secretion at both sites.
Positive_regulation (increased) of Gene_expression (expression) of trk in skin associated with nerve growth factor and trk a
5) Confidence 0.02 Published 2000 Journal Pain Section Abstract Doc Link 10692623 Disease Relevance 1.18 Pain Relevance 1.10

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