INT56769

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Context Info
Confidence 0.77
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 36
Total Number 37
Disease Relevance 15.79
Pain Relevance 20.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) endosome (Ntrk1) aging (Ntrk1)
plasma membrane (Ntrk1) cytoplasm (Ntrk1)
Anatomy Link Frequency
nerve 7
Schwann cells 5
lamina 4
neurons 3
sensory neurons 2
Ntrk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 217 100.00 Very High Very High Very High
Trk A 49 100.00 Very High Very High Very High
antagonist 16 100.00 Very High Very High Very High
Kappa opioid receptor 16 100.00 Very High Very High Very High
opioid receptor 10 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
antinociception 5 99.98 Very High Very High Very High
Somatostatin 16 99.84 Very High Very High Very High
unmyelinated 11 99.84 Very High Very High Very High
primary afferent fibers 4 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 128 99.96 Very High Very High Very High
Nociception 22 99.84 Very High Very High Very High
Cystitis 14 99.76 Very High Very High Very High
Contusions 26 99.74 Very High Very High Very High
Hypersensitivity 6 99.40 Very High Very High Very High
Tooth Injuries 8 98.84 Very High Very High Very High
Ganglion Cysts 25 98.66 Very High Very High Very High
INFLAMMATION 65 98.40 Very High Very High Very High
Demyelinating Disease 36 98.12 Very High Very High Very High
Overactive Bladder 47 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, Schwann cells of neighbouring unmyelinated fibres expressed prominent nerve growth factor receptor immunoreactivity.
Gene_expression (expressed) of nerve growth factor receptor in nerve associated with nerve growth factor and unmyelinated
1) Confidence 0.77 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.28 Pain Relevance 0.71
Following nerve transection nerve growth factor receptor is re-expressed at high levels in the Schwann cells of the denervated nerve fibres.
Gene_expression (expressed) of nerve growth factor receptor in nerve associated with nerve growth factor
2) Confidence 0.77 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.31 Pain Relevance 0.44
These data further indicate that expression of nerve growth factor receptor by Schwann cells does not require axonal degeneration, but can be stimulated by some factor associated with acute demyelination.
Gene_expression (expression) of nerve growth factor receptor in nerve associated with demyelination and nerve growth factor
3) Confidence 0.77 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.36 Pain Relevance 0.69
Both in 1 micron serial cryosections and in immunostained teased nerve fibres we found that the Schwann cells that were associated with demyelinated internodes expressed nerve growth factor receptor.
Gene_expression (expressed) of nerve growth factor receptor in nerve associated with nerve growth factor
4) Confidence 0.77 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.34 Pain Relevance 0.72
In completely demyelinated internodes the postmitotic Schwann cells ensheathing the axons expressed nerve growth factor receptor on their plasmalemma.
Gene_expression (expressed) of nerve growth factor receptor in Schwann cells associated with nerve growth factor
5) Confidence 0.77 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.30 Pain Relevance 0.75
Nerve growth factor receptor, expressed in Schwann cells during early development of the PNS, is rarely found in the normal mature PNS.
Gene_expression (expressed) of Nerve growth factor receptor in Schwann cells associated with nerve growth factor
6) Confidence 0.77 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.27 Pain Relevance 0.39
In this study we asked if demyelination caused by an immune-mediated process or by physical destruction of myelin is associated with expression of nerve growth factor receptor, and if so, what cells are positive.
Gene_expression (expression) of nerve growth factor receptor in nerve associated with demyelination and nerve growth factor
7) Confidence 0.77 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.35 Pain Relevance 0.55
This is the first demonstration that trkB receptors expressed by PN-PAF terminals in lamina II are functional during postnatal development.
Gene_expression (expressed) of trk in lamina
8) Confidence 0.75 Published 2008 Journal Dev Neurobiol Section Abstract Doc Link 18172890 Disease Relevance 0.06 Pain Relevance 0.65
In this preparation, BDNF (100-500 ng/mL) enhances the release of sensory neurotransmitters (glutamate, substance P, CGRP) in lamina II by acting on trkB receptors expressed by primary afferent fibers of the peptidergic nociceptive type (PN-PAFs).
Gene_expression (expressed) of trk in lamina associated with nociception, glutamate, neurotransmitter, primary afferent fibers and substance p
9) Confidence 0.75 Published 2008 Journal Dev Neurobiol Section Abstract Doc Link 18172890 Disease Relevance 0.18 Pain Relevance 0.50
At 336 h (14 days) after injury, trk A receptor expression had decreased such that grain density counts were not different from preinjury levels.
Gene_expression (expression) of trk A associated with trk a and injury
10) Confidence 0.75 Published 2000 Journal J Endod Section Abstract Doc Link 11194379 Disease Relevance 0.84 Pain Relevance 0.68
Time course of the increase in trk A expression in trigeminal neurons after tooth injury.
Gene_expression (expression) of trk A in neurons associated with tooth injuries, nociceptor and trk a
11) Confidence 0.75 Published 2000 Journal J Endod Section Title Doc Link 11194379 Disease Relevance 0.78 Pain Relevance 0.76
To characterize the role of trk A receptors in mediating NGF-induced signals to sensory neurons, trigeminal ganglia from adult male rats were examined for changes in expression of trk A as a function of time after injury to maxillary molar dentin.
Gene_expression (expression) of trk A in molar associated with nerve growth factor, trk a and injury
12) Confidence 0.75 Published 2000 Journal J Endod Section Abstract Doc Link 11194379 Disease Relevance 0.79 Pain Relevance 0.59
Neighbouring Schwann cells with intact myelin sheaths remained nerve growth factor receptor negative.
Neg (negative) Gene_expression (negative) of nerve growth factor receptor in Schwann cells associated with nerve growth factor
13) Confidence 0.67 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.29 Pain Relevance 0.74
Nerve growth factor receptor, expressed in Schwann cells during early development of the PNS, is rarely found in the normal mature PNS.
Gene_expression (expressed) of Nerve growth factor receptor in Schwann cells associated with nerve growth factor
14) Confidence 0.67 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 8106877 Disease Relevance 0.27 Pain Relevance 0.39
In this preparation, BDNF (100-500 ng/mL) enhances the release of sensory neurotransmitters (glutamate, substance P, CGRP) in lamina II by acting on trkB receptors expressed by primary afferent fibers of the peptidergic nociceptive type (PN-PAFs).
Gene_expression (expressed) of trk in lamina associated with nociception, glutamate, neurotransmitter, primary afferent fibers and substance p
15) Confidence 0.65 Published 2008 Journal Dev Neurobiol Section Abstract Doc Link 18172890 Disease Relevance 0.18 Pain Relevance 0.50
Presynaptic functional trkB receptors mediate the release of excitatory neurotransmitters from primary afferent terminals in lamina II (substantia gelatinosa) of postnatal rat spinal cord.
Gene_expression (Presynaptic) of trk in lamina associated with substantia gelatinosa, neurotransmitter and spinal cord
16) Confidence 0.65 Published 2008 Journal Dev Neurobiol Section Title Doc Link 18172890 Disease Relevance 0.16 Pain Relevance 0.45
Double-labeling studies demonstrated that both TrkB or TrkC receptors were located on somatostatin neurons.
Gene_expression (located) of Trk in neurons associated with somatostatin
17) Confidence 0.65 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.67
If NGF induces wound repair and/or nociceptive responses in tooth pulp, then changes in expression of NGF receptors (trk A receptors) in response to dentin injury would be expected.
Gene_expression (expression) of trk A in dentin associated with nociception, nerve growth factor, trk a and injury
18) Confidence 0.58 Published 2000 Journal J Endod Section Abstract Doc Link 11194379 Disease Relevance 0.68 Pain Relevance 0.56
CGRP-IR fibres almost disappeared at 2 weeks post-CCI, but quickly sprouted, leading to a significant peak above sham levels 4 weeks post-injury. trkA receptor expression was found to be up-regulated in small cutaneous nerves 4 weeks post-CCI, returning to sham levels by 8 weeks post-CCI.
Gene_expression (expression) of trkA receptor in nerves associated with eae, injury and calcitonin gene-related peptide
19) Confidence 0.58 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15932605 Disease Relevance 1.39 Pain Relevance 0.78
To confirm that the observed changes in gene expression in the transection model are an accurate portrayal of the TPS neuronal response to contusion injury, the expression of 8 different proteins (Gap43, Hspb1, Gfra1, Ret, Casp3, Ntrk1, Ntrk2, and Ntrk3) were examined immunofluorescently in DTMR retrogradely labeled TPS neurons following a moderate spinal contusion injury (NYU Impactor; 25 mm, 10 g weight drop).
Gene_expression (expression) of Ntrk1 in neuronal associated with injury and contusions
20) Confidence 0.49 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.93 Pain Relevance 0

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