INT56779

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Context Info
Confidence 0.31
First Reported 1994
Last Reported 1995
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Odc1) cell-cell signaling (Pomc) cytoplasm (Pomc)
cytosol (Odc1) extracellular space (Pomc) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
brain 2
pituitary 2
Pomc (Rattus norvegicus)
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 2 97.16 Very High Very High Very High
opioid receptor 8 95.08 Very High Very High Very High
Endogenous opioid 2 92.04 High High
antagonist 3 78.20 Quite High
Central nervous system 1 75.00 Quite High
Delta opioid receptors 1 73.76 Quite High
Opioid 2 59.76 Quite High
Neuropeptide 1 59.48 Quite High
Intracerebroventricular 1 52.92 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained demonstrate that i.c.v. beta-endorphin downregulates ODC expression in central as well as in peripheral tissues by interacting with brain mu-opioid receptors, but not with delta- or epsilon-opioid receptors or mu/delta-opioid receptor complexes.
beta-endorphin Negative_regulation (downregulates) of Gene_expression (expression) of ODC in brain associated with mu opioid receptor and opioid receptor
1) Confidence 0.31 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549635 Disease Relevance 0 Pain Relevance 0.80
The inhibition of liver ornithine decarboxylase expression in neonatal rats by maternal separation or CNS beta-endorphin is independent of the pituitary.
beta-endorphin Negative_regulation (inhibition) of Gene_expression (expression) of ornithine decarboxylase in pituitary
2) Confidence 0.26 Published 1994 Journal Life Sci. Section Title Doc Link 8107512 Disease Relevance 0 Pain Relevance 0.09

General Comments

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