INT5678

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 1992
Last Reported 2008
Negated 0
Speculated 4
Reported most in Abstract
Documents 17
Total Number 22
Disease Relevance 2.62
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRA2C) small molecule metabolic process (ADRA2C) plasma membrane (ADRA2C)
cell-cell signaling (ADRA2C) cytoplasm (ADRA2C) signal transducer activity (ADRA2C)
Anatomy Link Frequency
DRG 3
SH-SY5Y 1
plasma 1
brain 1
spinal cord dorsal horn 1
ADRA2C (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 61 100.00 Very High Very High Very High
analgesia 11 99.96 Very High Very High Very High
Clonidine 39 99.92 Very High Very High Very High
dorsal root ganglion 15 99.14 Very High Very High Very High
opiate 1 98.32 Very High Very High Very High
Dorsal horn 16 97.34 Very High Very High Very High
Potency 4 97.08 Very High Very High Very High
antagonist 8 97.00 Very High Very High Very High
Spinal cord 11 96.76 Very High Very High Very High
Thalamus 8 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Ganglion Cysts 15 99.14 Very High Very High Very High
Cancer 2 98.64 Very High Very High Very High
Pain 3 96.36 Very High Very High Very High
Cognitive Disorder 34 93.08 High High
Aids-related Complex 2 91.32 High High
Pressure Volume 2 Under Development 5 87.96 High High
Rhinitis 3 87.60 High High
Sleep Disorders 12 87.32 High High
Hemorrhage 3 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because 20% of dorsal horn alpha2ARs derive from cell bodies that reside in the associated dorsal root ganglion (DRG), it is important to evaluate alpha2AR expression in this tissue as well.
Gene_expression (expression) of alpha2AR in dorsal horn associated with ganglion cysts, dorsal root ganglion and dorsal horn
1) Confidence 0.74 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10754615 Disease Relevance 0.37 Pain Relevance 0.66
RESULTS: Overall expression of alpha2AR mRNA in DRG is low but reproducible at all spinal levels. alpha2b and alpha2cAR subtype mRNAs predominate (alpha2b approximately alpha2c), accounting for more than 95% of the total alpha2AR mRNA in DRG at all human spinal nerve root levels.
Gene_expression (expression) of alpha2AR mRNA in DRG
2) Confidence 0.74 Published 2000 Journal Anesthesiology Section Body Doc Link 10754615 Disease Relevance 0.08 Pain Relevance 0
METHODS: Molecular approaches were used to determine alpha2AR expression in 28 human DRGs because of low overall receptor mRNA expression and small sample size.
Spec (determine) Gene_expression (expression) of alpha2AR
3) Confidence 0.74 Published 2000 Journal Anesthesiology Section Body Doc Link 10754615 Disease Relevance 0.10 Pain Relevance 0
These findings also highlight species heterogeneity in alpha2AR expression in DRG.
Gene_expression (expression) of alpha2AR in DRG
4) Confidence 0.74 Published 2000 Journal Anesthesiology Section Body Doc Link 10754615 Disease Relevance 0.06 Pain Relevance 0
CONCLUSIONS: Predominance of alpha2b and alpha2cAR mRNA in human DRG is distinct from alpha2AR mRNA expression in cell bodies originating in human spinal cord dorsal horn, where alpha2a and alpha2b predominate with little or absent alpha2c expression.
Gene_expression (expression) of alpha2AR mRNA in DRG
5) Confidence 0.64 Published 2000 Journal Anesthesiology Section Body Doc Link 10754615 Disease Relevance 0.07 Pain Relevance 0
We recently demonstrated species heterogeneity in the distribution of alpha 1-adrenergic receptor subtypes, therefore making it imperative to analyze the distribution of alpha 2AR subtypes in human tissues.
Spec (analyze) Gene_expression (distribution) of alpha 2AR
6) Confidence 0.62 Published 1994 Journal Anesthesiology Section Abstract Doc Link 7978483 Disease Relevance 0.08 Pain Relevance 0.26
The analysis of the expression of alpha2-adrenoceptor subtypes by reverse transcriptase-polymerase chain reaction (RT-PCR) revealed the exclusive presence of alpha2C-adrenoceptor mRNA in SH-SY5Y cells.
Gene_expression (expression) of alpha2-adrenoceptor in SH-SY5Y
7) Confidence 0.57 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374721 Disease Relevance 0.38 Pain Relevance 0.30
Clonidine (CL) is a alpha2-adrenergic agonist that produces analgesia in animals and humans by a non-opiate alpha2-adrenergic action in the spinal cord dorsal horn.
Gene_expression (produces) of alpha2-adrenergic in spinal cord dorsal horn associated with dorsal horn, agonist, opiate, spinal cord, analgesia and clonidine
8) Confidence 0.50 Published 2006 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 16515665 Disease Relevance 0 Pain Relevance 1.28
We report here the transfection, selection and preliminary pharmacological characterization of two mammalian cell lines, adherent Shionogi S115 mouse mammary tumour cells and human B-lymphoblastoid IBW4 cells growing in suspension, expressing the human alpha 2-AR subtypes alpha 2-C4 and alpha 2-C10 at densities of approx. 2 x 10(5) receptors/cell.
Gene_expression (expressing) of alpha 2-AR associated with cancer
9) Confidence 0.45 Published 1992 Journal Biochim. Biophys. Acta Section Abstract Doc Link 1313304 Disease Relevance 0.10 Pain Relevance 0.09
We, therefore, investigated alphaAR subtype expression in human nasal turbinate within epithelial, duct, gland, and vessel cells using in situ hybridization.
Spec (investigated) Gene_expression (expression) of alphaAR in gland
10) Confidence 0.45 Published 2007 Journal Can J Anaesth Section Abstract Doc Link 17602041 Disease Relevance 0.17 Pain Relevance 0.20
Cloning of the genes encoding distinct subtypes of human alpha 2-adrenergic receptors (alpha 2-AR) allows the separate recombinant expression of each individual subtype in heterologous systems.
Gene_expression (expression) of alpha 2-AR
11) Confidence 0.45 Published 1992 Journal Biochim. Biophys. Acta Section Abstract Doc Link 1313304 Disease Relevance 0.08 Pain Relevance 0
RESULTS: In non-vascular tissue alpha(1d) AR mRNA predominates, whereas notably the alpha(2c) is the only alphaAR subtype present in the sinusoids and arteriovenous anastamoses.
Gene_expression (present) of alphaAR
12) Confidence 0.39 Published 2007 Journal Can J Anaesth Section Body Doc Link 17602041 Disease Relevance 0 Pain Relevance 0
Cooling augmented alpha 2-adrenergic vasoconstriction produced by clonidine; this effect was reduced by yohimbine, an alpha 2-adrenergic antagonist.
Gene_expression (produced) of alpha 2-adrenergic associated with antagonist, increased venous pressure under development and clonidine
13) Confidence 0.30 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1329562 Disease Relevance 0.34 Pain Relevance 0.24
Two human alpha 2-adrenoceptor subtypes alpha 2A-C10 and alpha 2B-C2 expressed in Sf9 cells couple to transduction pathway resulting in opposite effects on cAMP production.
Gene_expression (expressed) of alpha 2-adrenoceptor
14) Confidence 0.19 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 8575536 Disease Relevance 0 Pain Relevance 0.21
The baculovirus expression vector system utilizing the strong polyhedrin gene promoter of the Autographa californica nuclear polyhedrosis virus (AcNPV) was used for high level expression of the two alpha 2-adrenoceptor subtypes alpha 2A-C10 and alpha 2B-C2 in Spodoptera frugiperda (Sf-9) insect cells.
Gene_expression (expression) of alpha 2-adrenoceptor
15) Confidence 0.19 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8575536 Disease Relevance 0 Pain Relevance 0.20
We, therefore, investigated alphaAR subtype expression in human nasal turbinate within epithelial, duct, gland, and vessel cells using in situ hybridization.
Spec (investigated) Gene_expression (expression) of alphaAR in duct
16) Confidence 0.15 Published 2007 Journal Can J Anaesth Section Abstract Doc Link 17602041 Disease Relevance 0.17 Pain Relevance 0.20
The alpha-2A and alpha-2C subtypes are widely distributed in the brain, including the PFC, the alpha-2B receptor is most concentrated in the thalamus.
Gene_expression (distributed) of alpha-2C in brain associated with thalamus
17) Confidence 0.13 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.15 Pain Relevance 0.31
Atomoxetine, which also has sedating effects in some children, may also have alpha-2B and/or alpha-2C effects [48].
Gene_expression (effects) of alpha-2C
18) Confidence 0.11 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.07 Pain Relevance 0.25
At low densities of alpha2C-adrenoceptors, clonidine was a partial agonist, but in clones expressing high levels of alpha2C-adrenoceptors, clonidine acted as a full agonist by inhibiting cAMP accumulation with the same efficacy as (-)-noradrenaline.
Gene_expression (expressing) of alpha2C-adrenoceptors associated with noradrenaline, agonist and clonidine
19) Confidence 0.08 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.12 Pain Relevance 0.43
RX 811059 (10 microM) was the only compound to be completely silent at both the wt and mutant alpha2 AR subtypes.
Gene_expression (silent) of alpha2 AR
20) Confidence 0.04 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11383713 Disease Relevance 0 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox