INT56785

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Context Info
Confidence 0.54
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.85
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SP110) nucleus (SP110) DNA binding (SP110)
signal transducer activity (SP110)
Anatomy Link Frequency
HL-60 3
locus coeruleus 1
SP110 (Homo sapiens)
Pain Link Frequency Relevance Heat
Locus ceruleus 1 95.52 Very High Very High Very High
Clonidine 2 81.28 Quite High
medulla 2 79.04 Quite High
cva 5 57.44 Quite High
Inflammatory response 5 49.16 Quite Low
headache 5 42.08 Quite Low
Disease Link Frequency Relevance Heat
Hypotension 2 99.60 Very High Very High Very High
Infection 150 99.04 Very High Very High Very High
Sleep Disorders 2 98.76 Very High Very High Very High
Rickettsiaceae Infection 5 94.48 High High
Vesicular Stomatitis 5 81.68 Quite High
Toxocariasis 1 79.24 Quite High
Influenza Virus Infection 5 79.20 Quite High
Pressure And Volume Under Development 1 78.56 Quite High
Hepatitis C Virus Infection 5 66.88 Quite High
Immunodeficiency 5 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, it has been recently confirmed that hypotension is mediated by the activation of imidazoline preferring receptors (IPR) within the NRL region, while sedation is attributed to the inhibition of alpha 2-adrenergic mechanisms in the locus coeruleus, which is involved in the control of the sleep-waking cycle.
Positive_regulation (activation) of IPR in locus coeruleus associated with locus ceruleus, hypotension and sleep disorders
1) Confidence 0.54 Published 1993 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 8107594 Disease Relevance 0.51 Pain Relevance 0.27
The increase in Sp110 mRNA levels coincided with pathogen multiplication and increasing infections (Fig. 1) and may reflect a protective cellular response to limit rickettsial infection or the result of the manipulation by A. phagocytophilum of host gene transcription to promote pathogen multiplication.
Positive_regulation (increase) of Sp110 mRNA associated with rickettsiaceae infection and infection
2) Confidence 0.50 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.38 Pain Relevance 0
While Sp110 mRNA levels increased concurrently with A. phagocytophilum infections in HL-60 cells, the silencing of Sp110 expression by RNA interference resulted in decreased infection levels.


Positive_regulation (increased) of Sp110 mRNA in HL-60 associated with infection
3) Confidence 0.47 Published 2007 Journal BMC Infect Dis Section Abstract Doc Link PMC2039740 Disease Relevance 0.80 Pain Relevance 0
However, although Sp110 protein levels were not determined, the results of RNAi suggested that Sp110 was required for A. phagocytophilum infection and/or multiplication in HL-60 cells.
Positive_regulation (required) of Sp110 in HL-60 associated with infection
4) Confidence 0.47 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.46 Pain Relevance 0
In summary, we have shown that A. phagocytophilum increases Sp110 mRNA levels in infected human promyelocytic HL-60 cells.
Positive_regulation (increases) of Sp110 mRNA in HL-60
5) Confidence 0.47 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 0.43 Pain Relevance 0
Sp110 and other NB-associated proteins, induced by type I (?
Positive_regulation (induced) of Sp110
6) Confidence 0.47 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC2039740 Disease Relevance 1.28 Pain Relevance 0.03

General Comments

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