INT56786

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SP110) nucleus (SP110) DNA binding (SP110)
signal transducer activity (SP110)
Anatomy Link Frequency
locus coeruleus 2
SP110 (Homo sapiens)
Pain Link Frequency Relevance Heat
Locus ceruleus 1 95.52 Very High Very High Very High
Clonidine 2 81.92 Quite High
medulla 2 79.68 Quite High
Disease Link Frequency Relevance Heat
Hypotension 2 99.92 Very High Very High Very High
Sleep Disorders 2 98.76 Very High Very High Very High
Toxocariasis 1 79.88 Quite High
Pressure And Volume Under Development 1 78.56 Quite High
Disease 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, it has been recently confirmed that hypotension is mediated by the activation of imidazoline preferring receptors (IPR) within the NRL region, while sedation is attributed to the inhibition of alpha 2-adrenergic mechanisms in the locus coeruleus, which is involved in the control of the sleep-waking cycle.
Positive_regulation (mediated) of Positive_regulation (activation) of IPR in locus coeruleus associated with locus ceruleus, hypotension and sleep disorders
1) Confidence 0.39 Published 1993 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 8107594 Disease Relevance 0.52 Pain Relevance 0.27

General Comments

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