INT5679

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Context Info
Confidence 0.40
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.39
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (RNASE1)
Anatomy Link Frequency
saliva 1
cell components 1
RNASE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 22 99.72 Very High Very High Very High
Chronic pancreatitis 4 81.28 Quite High
Opioid 2 79.16 Quite High
agonist 4 77.36 Quite High
Codeine 109 70.24 Quite High
noradrenaline 2 66.64 Quite High
Clonidine 1 55.76 Quite High
tolerance 42 50.00 Quite Low
corticosteroid 3 43.68 Quite Low
chemokine 1 42.88 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 14 99.32 Very High Very High Very High
Infection 11 97.12 Very High Very High Very High
Pancreatic Cancer 13 89.76 High High
Carcinoma 2 86.48 High High
Cancer 35 85.16 High High
Apoptosis 2 83.60 Quite High
Obesity 35 83.32 Quite High
Adenoma 1 83.04 Quite High
Sprains And Strains 1 76.80 Quite High
Aggression 1 71.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stable expression of recombinant human alpha 2-adrenoceptor subtypes in two mammalian cell lines: characterization with [3H]rauwolscine binding, inhibition of adenylate cyclase and RNase protection assay.
Negative_regulation (inhibition) of RNase
1) Confidence 0.40 Published 1992 Journal Biochim. Biophys. Acta Section Title Doc Link 1313304 Disease Relevance 0.09 Pain Relevance 0.15
The data show that HIV-1 replication is potentiated and RNase L activity is inhibited after morphine administration.
Negative_regulation (inhibited) of RNase associated with acquired immune deficiency syndrome or hiv infection and morphine
2) Confidence 0.30 Published 2002 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12048358 Disease Relevance 0.75 Pain Relevance 0.65
Because the pancreatic juice has strong protease and RNase activity, addition of protease inhibitors and RNase inhibitors in the telomerase extraction buffer is necessary for the detection of telomerase activity in the pancreatic juice.
Negative_regulation (inhibitors) of RNase
3) Confidence 0.29 Published 2005 Journal Methods Mol. Med. Section Abstract Doc Link 15542908 Disease Relevance 0.85 Pain Relevance 0.08
On the other hand, a reagent such as an RNase inhibitor included in RNAlater® may be easy to instill into the tissues and/or their cell components for the same reason.
Negative_regulation (inhibitor) of RNase in cell components
4) Confidence 0.21 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2867810 Disease Relevance 0.49 Pain Relevance 0
Although with the use of certain RNase inhibitors mRNA can be stabilized for longer run even in room temperature [39], however cooling of saliva samples on ice (+4°C) is still useful [26].
Negative_regulation (inhibitors) of RNase in saliva
5) Confidence 0.13 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674305 Disease Relevance 0.05 Pain Relevance 0
Thirty units of avian myeloblastososis virus, 200 ng of random primers, 20 units of ribonuclease inhibitor, and 40 nmol of deoxy–nucleoside triphosphates with 5× reaction buffer were added to the RNA, and the reverse transcriptase reaction was carried out at 37°C for 1 h.
Negative_regulation (inhibitor) of ribonuclease
6) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.08 Pain Relevance 0
-32P]UTP, 40 U RNase inhibitor and 50 U T7 RNA polymerase.
Negative_regulation (inhibitor) of RNase
7) Confidence 0.01 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0.08 Pain Relevance 0.12

General Comments

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