INT5680

Context Info Confidence 0.78 First Reported 1980 Last Reported 2011 Negated 14 Speculated 27 Reported most in Abstract Documents 530 Total Number 563 Disease Relevance 264.29 Pain Relevance 310.56

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf) extracellular region (Ngf) molecular_function (Ngf)

Anatomy Link Frequency nerve 122 neurons 29 DRG 25 bladder 24 brain 16 Ngf (Rattus norvegicus) Ngf - R221W (1)

Pain Link Frequency Relevance Heat Nerve growth factor 15547 100.00 Sciatic nerve 1555 100.00 Spinal cord 1471 100.00 Inflammation 1299 100.00 Calcitonin gene-related peptide 1285 100.00 Pain 1250 100.00 qutenza 848 100.00 substance P 577 100.00 nociceptor 511 100.00 dorsal root ganglion 463 100.00

Disease Link Frequency Relevance Heat Injury 2546 100.00 INFLAMMATION 1387 100.00 Ganglion Cysts 1182 100.00 Nociception 609 100.00 Cancer 371 100.00 Necrosis 85 100.00 Shock 36 100.00 Burns 13 100.00 Asthma 8 100.00 Hyperalgesia 733 99.98

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A substantial increase in NGF protein expression occurred in skin 4-h, 1-day and 2-days and 5-days after incision comparing contralateral uninjured skin.

Gene_expression (expression) of NGF protein in skin associated with nerve growth factor

1) Confidence 0.78 Published 2005 Journal Pain Section Abstract Doc Link 16061324 Disease Relevance 0.42 Pain Relevance 0.74

This suggests that expression of capsaicin sensitivity in DRG is maximal at levels of NGF found in normal animals.

Gene_expression (levels) of NGF in DRG associated with dorsal root ganglion, nerve growth factor and qutenza

2) Confidence 0.78 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8834108 Disease Relevance 0.62 Pain Relevance 1.00

We also analyzed changes in the expression of nerve growth factor (NGF), which is involved in plasticity of the nociceptive circuit after nerve injury.

Gene_expression (expression) of nerve growth factor in nerve associated with nociception, nervous system injury and nerve growth factor

3) Confidence 0.78 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18165597 Disease Relevance 0.55 Pain Relevance 0.79

We also analyzed changes in the expression of nerve growth factor (NGF), which is involved in plasticity of the nociceptive circuit after nerve injury.

Spec (analyzed) Gene_expression (expression) of NGF in nerve associated with nociception, nervous system injury and nerve growth factor

4) Confidence 0.78 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18165597 Disease Relevance 0.55 Pain Relevance 0.79

Therapeutic strategies targeting spinal cord cells that produce NGF may prevent primary afferent sprouting and resulting clinical disorders after cord injury.

Gene_expression (produce) of NGF in spinal cord associated with nerve growth factor, injury and spinal cord

5) Confidence 0.78 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10646525 Disease Relevance 0.35 Pain Relevance 0.58

The skin immediately adjacent to the incision had the greatest NGF expression.

Gene_expression (expression) of NGF in skin

6) Confidence 0.78 Published 2007 Journal Anesthesiology Section Body Doc Link 17585224 Disease Relevance 0 Pain Relevance 0

The purpose of this study is to examine the expression of NGF in skin after planter incision.

Spec (examine) Gene_expression (expression) of NGF in skin associated with nerve growth factor

7) Confidence 0.78 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17585224 Disease Relevance 0.37 Pain Relevance 0.55

NGF protein expression was detected by Western blot and immunohistochemistry in incisions.

Gene_expression (expression) of NGF protein

8) Confidence 0.78 Published 2007 Journal Anesthesiology Section Body Doc Link 17585224 Disease Relevance 0 Pain Relevance 0

CONCLUSION: NGF mRNA is increased and a large-molecular-weight form of NGF protein is expressed in the region adjacent to the incision.

Gene_expression (expressed) of NGF protein

9) Confidence 0.78 Published 2007 Journal Anesthesiology Section Body Doc Link 17585224 Disease Relevance 0 Pain Relevance 0

At 3-7 days after transection or clip-compression SCI, NGF mRNA and protein were expressed in the lesion and throughout the intermediate grey matter and white matter rostral and caudal to the injury site.

Gene_expression (expressed) of NGF mRNA in white matter associated with nerve growth factor, injury and frailty

10) Confidence 0.78 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15191808 Disease Relevance 0.99 Pain Relevance 0.66

Rounded macrophages in the lesion were immunoreactive (Ir) for NGF, but the cells expressing NGF mRNA were not in the same areas of the lesion and were not stained by a macrophage marker.

Gene_expression (expressing) of NGF mRNA in macrophage associated with nerve growth factor

11) Confidence 0.78 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15191808 Disease Relevance 0.71 Pain Relevance 0.49

Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis.

Gene_expression (expression) of Nerve growth factor in Nerve associated with nerve growth factor and pancreatitis

12) Confidence 0.78 Published 2000 Journal Gastroenterology Section Title Doc Link 11054396 Disease Relevance 0.38 Pain Relevance 0.47

The NGF-induced recovery of noradrenergic nerves was independent of the presence of sensory peptidergic afferents and it could not be mimicked by a local inflammatory response known to raise endogenous NGF production.

Gene_expression (production) of NGF in nerves associated with inflammatory response

13) Confidence 0.78 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014174 Disease Relevance 0.10 Pain Relevance 0.29

Prior studies have demonstrated an association between visceral inflammation, an increase in nerve growth factor (NGF) expression, and development of hyperalgesia.

Gene_expression (expression) of NGF in visceral associated with hyperalgesia, nerve growth factor and inflammation

14) Confidence 0.78 Published 2004 Journal J Pain Section Abstract Doc Link 15106127 Disease Relevance 0.29 Pain Relevance 0.48

These data demonstrate that a transient increase in NGF expression without associated inflammation sensitizes visceral reflex pathways, leading to bladder overactivity.

Gene_expression (expression) of NGF in bladder associated with inflammation and nerve growth factor

15) Confidence 0.78 Published 2004 Journal J Pain Section Abstract Doc Link 15106127 Disease Relevance 0.46 Pain Relevance 0.86

Prior studies have demonstrated an association between visceral inflammation, an increase in nerve growth factor (NGF) expression, and development of hyperalgesia.

Gene_expression (expression) of nerve growth factor in visceral associated with hyperalgesia, nerve growth factor and inflammation

16) Confidence 0.78 Published 2004 Journal J Pain Section Abstract Doc Link 15106127 Disease Relevance 0.29 Pain Relevance 0.48

Increased nerve growth factor expression triggers bladder overactivity.

Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor

17) Confidence 0.78 Published 2004 Journal J Pain Section Title Doc Link 15106127 Disease Relevance 0.40 Pain Relevance 0.71

Expression of NGF led to bladder overactivity, whereas beta-galactosidase expression was without effect.

Gene_expression (Expression) of NGF in bladder associated with nerve growth factor

18) Confidence 0.78 Published 2004 Journal J Pain Section Abstract Doc Link 15106127 Disease Relevance 0.46 Pain Relevance 0.86

We also found that NGF produced plasma extravasation in rat skin, using the Evan's blue method, with a dose dependency similar to that determined for hyperalgesia.

Gene_expression (produced) of NGF in skin associated with hyperalgesia and nerve growth factor

19) Confidence 0.78 Published 1995 Journal Pain Section Abstract Doc Link 8577480 Disease Relevance 0.60 Pain Relevance 0.97

Cerebellar and striatal, but not hippocampal, astrocytes prepared from naltrexone-treated animals produced higher levels of NGF than those from controls.

Gene_expression (produced) of NGF in astrocytes associated with nerve growth factor

20) Confidence 0.78 Published 1993 Journal J. Mol. Neurosci. Section Abstract Doc Link 7686388 Disease Relevance 0 Pain Relevance 0.62

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