INT56809

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2011
Negated 9
Speculated 7
Reported most in Body
Documents 184
Total Number 195
Disease Relevance 106.02
Pain Relevance 31.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 6
lung 6
microglia 5
immune system 4
astrocytes 4
Tlr4 (Mus musculus)
Tlr4 - D299G (1)
Pain Link Frequency Relevance Heat
Inflammation 2957 100.00 Very High Very High Very High
agonist 495 100.00 Very High Very High Very High
ketamine 170 99.98 Very High Very High Very High
Paracetamol 75 99.90 Very High Very High Very High
isoflurane 48 99.90 Very High Very High Very High
antagonist 311 99.84 Very High Very High Very High
cytokine 1720 99.64 Very High Very High Very High
Hippocampus 77 99.64 Very High Very High Very High
Inflammatory response 526 99.40 Very High Very High Very High
spastic colon 171 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3444 100.00 Very High Very High Very High
Chlamydia Infection 444 100.00 Very High Very High Very High
Hemolytic Uremic Syndrome 410 100.00 Very High Very High Very High
Injury 1635 99.86 Very High Very High Very High
Lung Injury 133 99.72 Very High Very High Very High
Heart Rate Under Development 65 99.68 Very High Very High Very High
Burns 1444 99.64 Very High Very High Very High
Thrombocytopenia 31 99.56 Very High Very High Very High
Infection 1527 99.40 Very High Very High Very High
Fever 173 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As consequence of TLR4 binding, the repeated treatment with FP-1 prevented the activation of the transcription factor NF-kB and the TNFalpha overproduction in the spinal cord.
TLR4 Binding (binding) of in spinal cord associated with spinal cord
1) Confidence 0.48 Published 2008 Journal Glia Section Abstract Doc Link 18615568 Disease Relevance 1.05 Pain Relevance 0.95
Binding of an endogenous ligand to TLR4 might be considered an important step in the regulation of microglia activity in pain facilitation, suggesting that a mechanism aimed to inhibit such a binding could be effective against neuropathic pain.
TLR4 Spec (might) Binding (Binding) of in microglia associated with pain and neuropathic pain
2) Confidence 0.48 Published 2008 Journal Glia Section Abstract Doc Link 18615568 Disease Relevance 0.77 Pain Relevance 0.88
TLR2 and TLR4, have been shown to be essential for the recognition of distinct bacterial cell wall components.
TLR4 Binding (recognition) of
3) Confidence 0.48 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.88 Pain Relevance 0.17
TLR4-mediated recognition of LPS is required for efficient recognition of Gram-negative bacterial infections and some studies shows important roles that TLR4 plays with respect to LPS binding and signaling even in H. pylori infection [16].
TLR4 Binding (binding) of associated with bacterial infection and infection
4) Confidence 0.47 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 1.04 Pain Relevance 0.03
Because of the important roles that TLR4 play with respect to LPS binding and signaling, we hypothesized that polymorphisms in the TLR4 gene may be important factors for determining the long term outcome of the H. pylori infection.
TLR4 Binding (binding) of associated with infection
5) Confidence 0.47 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 0.30 Pain Relevance 0.03
Thus, the exact nature of the interaction between TLR-4, fatty acids and endotoxin requires further investigation.
TLR-4 Binding (interaction) of
6) Confidence 0.46 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.67 Pain Relevance 0.20
Our data support the work of Held et al that mechanical ventilation with normal tidal volumes does not generate endogenous ligands recognized by TLR4.
TLR4 Binding (recognized) of
7) Confidence 0.43 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.35 Pain Relevance 0.18
TLR4-mediated recognition of LPS is required for efficient recognition of Gram-negative bacterial infections and some studies shows important roles that TLR4 plays with respect to LPS binding and signaling even in H. pylori infection [16].
LPS Binding (recognition) of associated with bacterial infection and infection
8) Confidence 0.41 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 0.92 Pain Relevance 0
An acute injection of lipopolysaccharide (LPS, a TLR4 ligand) in the hippocampus reduced A?
TLR4 Binding (ligand) of in hippocampus associated with hippocampus
9) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.16 Pain Relevance 0.14
TLR4 ligand increased bacterial killing activity of peritoneal cells in burn group
TLR4 Binding (ligand) of associated with burns
10) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.17 Pain Relevance 0.04
B DNA-binding activity, TLR4 mRNA and protein expression assay at 8 hr after burn injury.


TLR4 mRNA Binding (activity) of associated with burns and injury
11) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.26 Pain Relevance 0.17
TLR4 ligand did not change the bacterial killing activity of peritoneal cells in C3H/HeJ mice
TLR4 Binding (ligand) of
12) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.83 Pain Relevance 0
In another experiment, the lung tissue was harvested for the assay of TLR2, TLR4, and TNF?
TLR4 Binding (assay) of in lung
13) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.56 Pain Relevance 0.14
At 8 hr after thermal injury, lung was harvested for TLR4 mRNA assay, intestinal mucosa was harvested for TLR4 mRNA assay, and peritoneal cells were harvested from the abdominal cavity for bacterial killing activity and TLR4 as well as TNF?
TLR4 mRNA Binding (assay) of in cavity associated with injury
14) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.34 Pain Relevance 0.04
TLR4 ligand did not change TLR4 and TNF?
TLR4 Binding (ligand) of
15) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.55 Pain Relevance 0.05
At 8 hr after thermal injury, lung was harvested for TLR4 mRNA assay, intestinal mucosa was harvested for TLR4 mRNA assay, and peritoneal cells were harvested from the abdominal cavity for bacterial killing activity and TLR4 as well as TNF?
TLR4 mRNA Binding (assay) of in cavity associated with injury
16) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.36 Pain Relevance 0.04
B DNA-binding activity, TLR4 mRNA and protein expression assay at 8 hr after burn injury.


TLR4 mRNA Binding (binding) of associated with burns and injury
17) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.26 Pain Relevance 0.17
Altogether, our data suggest that TLR4 ligand activates the NF-?
TLR4 Binding (ligand) of
18) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.95 Pain Relevance 0.07
TLR4 ligand increased TLR4 and TNF?
TLR4 Binding (ligand) of
19) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.50 Pain Relevance 0.05
TLR4 ligand did not change bacterial translocation in C3H/HeJ mice
TLR4 Binding (ligand) of
20) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.19 Pain Relevance 0

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