INT56816

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 14
Disease Relevance 4.92
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tk1) kinase activity (Tk1) cytoplasm (Tk1)
Anatomy Link Frequency
plasma 2
smooth muscle 1
B cells 1
brain 1
T cells 1
Tk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 100.00 Very High Very High Very High
tetrodotoxin 1 99.20 Very High Very High Very High
palliative 1 99.12 Very High Very High Very High
agonist 1 83.60 Quite High
Pain 4 82.16 Quite High
Bioavailability 1 71.04 Quite High
fibrosis 2 70.88 Quite High
Substantia nigra 1 68.80 Quite High
Thalamus 1 65.92 Quite High
Post herpetic neuralgia 1 54.60 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 12 100.00 Very High Very High Very High
Cancer 6 93.40 High High
Sprains And Strains 9 89.36 High High
Hypoalbuminemia 8 86.60 High High
Herpes Zoster 16 86.56 High High
Infection 5 86.24 High High
Hematological Disease 16 85.92 High High
Reprotox - General 1 18 83.60 Quite High
Metastasis 12 82.32 Quite High
Pain 4 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SAS performed the determination of expression levels of prostatic TS and TK mRNA.
Gene_expression (expression) of TK mRNA
1) Confidence 0.59 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.07 Pain Relevance 0
In prostate, BrdU-immunoreactive (S-phase) cells, and TS and TK mRNA expression levels were markedly affected by a zinc deficiency.
Gene_expression (expression) of TK mRNA
2) Confidence 0.59 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.28 Pain Relevance 0
The levels of TS mRNA and TK mRNA were determined by densitometry from photographs taken with an image analyzer (AE6920-MF Densitograph, ATTO, Tokyo), and are expressed as a ratio of the mRNA level of ?
Gene_expression (expressed) of TK mRNA
3) Confidence 0.51 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.12 Pain Relevance 0
RT-PCR was performed for quantitative analysis of TS and TK mRNA levels in the prostate.
Gene_expression (levels) of TK mRNA
4) Confidence 0.51 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0 Pain Relevance 0
In the present study, we investigated the effects of a low-zinc diet on body growth, organ weights, hemograms and plasma levels of biochemical markers and hormones, and the expression levels of TS and TK mRNA and BrdU-immunoreactive cells in the prostate of growing rats.


Gene_expression (expression) of TK mRNA in plasma
5) Confidence 0.46 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.15 Pain Relevance 0
In the present study, we investigated the effects of a low-zinc diet on body growth, organ weights, hemograms, plasma biochemical markers, plasma levels of hormones, and the BrdU-incorporation and TS and TK mRNA expression into the prostate cells in growing rats.
Gene_expression (expression) of TK mRNA in plasma
6) Confidence 0.46 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.29 Pain Relevance 0
Expression levels of TS and TK mRNA in prostate
Gene_expression (levels) of TK mRNA
7) Confidence 0.46 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.12 Pain Relevance 0
Expression levels of TS and TK mRNA in prostate
Gene_expression (Expression) of TK mRNA
8) Confidence 0.46 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2397411 Disease Relevance 0.12 Pain Relevance 0
The virus utilized was thymidine kinase (TK) deficient and therefore replication deficient in the brain. 3.
Gene_expression (deficient) of TK in brain
9) Confidence 0.32 Published 1993 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8111822 Disease Relevance 0.15 Pain Relevance 0.07
Activation of protease-activated receptor-1 (PAR-1) produces a dual action, apamin-sensitive relaxation followed by contraction, in the rat duodenal smooth muscle, which is partially dependent on activation of L-type Ca2+ channels, protein kinase C (PKC) or tyrosine kinase (TK), and resistant to tetrodotoxin.
Gene_expression (produces) of TK in smooth muscle associated with tetrodotoxin and kinase c
10) Confidence 0.29 Published 2000 Journal Life Sci. Section Abstract Doc Link 11065174 Disease Relevance 0 Pain Relevance 0.24
Changes of thymidine kinase (TK) during adjuvant and palliative chemotherapy.
Gene_expression (Changes) of TK associated with palliative
11) Confidence 0.09 Published 2005 Journal Anticancer Res. Section Title Doc Link 16033109 Disease Relevance 0.09 Pain Relevance 0.10
Therefore, cross-resistance to these drugs may be expected for those virus mutants that are TK-deficient and thus resistant to aciclovir.
Gene_expression (deficient) of TK
12) Confidence 0.07 Published 1999 Journal Drugs Section Abstract Doc Link 10188760 Disease Relevance 0.99 Pain Relevance 0.09
CD8-positive T cells were predominant compared with CD4-positive T cells, B cells (L26 positive), and natural killer cells (CD56 positive) in posttreated tissue specimens; (5). levels of HSV TK gene transduction correlated well with coxsackie-adenovirus receptor expression but less well with the titers of adenovirus injected; and (6). intrinsic OC expression and the efficiency of HSV TK gene transduction affected the levels of HSV TK protein expression in clinical specimens.
Gene_expression (expression) of TK gene in T cells associated with cold sores
13) Confidence 0.00 Published 2003 Journal Hum. Gene Ther. Section Abstract Doc Link 12639303 Disease Relevance 1.27 Pain Relevance 0.20
CD8-positive T cells were predominant compared with CD4-positive T cells, B cells (L26 positive), and natural killer cells (CD56 positive) in posttreated tissue specimens; (5). levels of HSV TK gene transduction correlated well with coxsackie-adenovirus receptor expression but less well with the titers of adenovirus injected; and (6). intrinsic OC expression and the efficiency of HSV TK gene transduction affected the levels of HSV TK protein expression in clinical specimens.
Gene_expression (expression) of TK gene in B cells associated with cold sores
14) Confidence 0.00 Published 2003 Journal Hum. Gene Ther. Section Abstract Doc Link 12639303 Disease Relevance 1.27 Pain Relevance 0.20

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