INT56817

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2009
Negated 2
Speculated 4
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 10.64
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Eno2) plasma membrane (Eno2) intracellular (Eno2)
cytoplasm (Eno2)
Anatomy Link Frequency
neuron 15
neural 2
neuronal 1
CSF 1
brain 1
Eno2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Gabapentin 4 100.00 Very High Very High Very High
anesthesia 9 97.76 Very High Very High Very High
imagery 13 94.88 High High
Inflammation 9 93.28 High High
Pain 9 91.96 High High
ischemia 6 91.96 High High
Central nervous system 5 90.00 High High
Dopamine 5 84.96 Quite High
Hippocampus 2 80.16 Quite High
cva 5 79.28 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 2 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 15 99.84 Very High Very High Very High
Paraganglioma 13 99.68 Very High Very High Very High
Cancer 71 99.08 Very High Very High Very High
Cognitive Disorder 11 99.08 Very High Very High Very High
Recurrence 7 98.20 Very High Very High Very High
Granular Cell Tumor 10 98.00 Very High Very High Very High
Disease 10 97.76 Very High Very High Very High
Myocardial Infarction 30 97.36 Very High Very High Very High
Rheumatoid Arthritis 1 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S-100beta protein and Neuron-Specific Enolase levels were unaffected by anesthetic technique.


Neg (unaffected) Regulation (unaffected) of Neuron-Specific Enolase in Neuron
1) Confidence 0.61 Published 2005 Journal Can J Anaesth Section Body Doc Link 15684252 Disease Relevance 0 Pain Relevance 0
We sought to determine the anatomical specificity and efficiency of herpesvirus-mediated gene transfer into the rat brain following placement of virus particles carrying a transgene (lacZ) under control of the NSE promoter.
Regulation (control) of NSE promoter in brain
2) Confidence 0.52 Published 1993 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8111822 Disease Relevance 0.14 Pain Relevance 0.06
Cytoplasm granules are typically seen under light microscopy, and the cells are positive for S100 immunoperoxidase and neuron-specific enolase.
Regulation (positive) of neuron-specific enolase in neuron
3) Confidence 0.44 Published 2008 Journal Brazilian journal of otorhinolaryngology Section Abstract Doc Link 19082363 Disease Relevance 1.38 Pain Relevance 0.09
Histological section of the tumour tissue revealed paraganglioma, which stained positive for chromogranin and neuron-specific enolase.
Regulation (positive) of neuron-specific enolase in neuron associated with cancer and paraganglioma
4) Confidence 0.44 Published 2005 Journal Ann. Clin. Biochem. Section Abstract Doc Link 15802039 Disease Relevance 0.64 Pain Relevance 0.38
AIM: To investigate the effect of gabapentin on neural [neuron-specific enolase (NSE)] and glial markers [glial fibrillary acidic protein (GFAP) and S100B] in different brain regions of diabetic rats.
Spec (investigate) Regulation (effect) of NSE in neural associated with diabetes mellitus and gabapentin
5) Confidence 0.42 Published 2005 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 15780189 Disease Relevance 0.17 Pain Relevance 0.21
AIM: To investigate the effect of gabapentin on neural [neuron-specific enolase (NSE)] and glial markers [glial fibrillary acidic protein (GFAP) and S100B] in different brain regions of diabetic rats.
Spec (investigate) Regulation (effect) of neuron-specific enolase in neural associated with diabetes mellitus and gabapentin
6) Confidence 0.36 Published 2005 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 15780189 Disease Relevance 0.17 Pain Relevance 0.21
Changes in S-100beta protein and Neuron-Specific Enolase levels were also documented.
Regulation (Changes) of Neuron-Specific Enolase in Neuron
7) Confidence 0.27 Published 2005 Journal Can J Anaesth Section Body Doc Link 15684252 Disease Relevance 0 Pain Relevance 0
Neuron specific enolase was unchanged during the course of the study.
Neg (unchanged) Regulation (unchanged) of Neuron specific enolase in Neuron
8) Confidence 0.23 Published 2002 Journal Acta Anaesthesiol Scand Section Body Doc Link 11952437 Disease Relevance 0.06 Pain Relevance 0
The aim of the present study was to investigate the value of S-100 and neuron specific enolase (NSE) in reflecting postoperative cognitive deficit (POCD) after general surgical procedures.
Spec (investigate) Regulation (value) of neuron specific enolase in neuron associated with cognitive disorder
9) Confidence 0.23 Published 2002 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 11952437 Disease Relevance 0.45 Pain Relevance 0.12
Immunohistochemical examinations showed that it was positive for neuron-specific enolase, chromogranin A and adrenocorticotropin.
Regulation (positive) of neuron-specific enolase in neuron
10) Confidence 0.21 Published 2008 Journal Eur Surg Res Section Abstract Doc Link 17717420 Disease Relevance 0.67 Pain Relevance 0.08
Changes in serum neuron-specific enolase (NSE) levels were monitored constantly during the progress of the disease.
Regulation (Changes) of serum neuron-specific enolase in neuron associated with disease
11) Confidence 0.07 Published 2005 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 15754108 Disease Relevance 1.32 Pain Relevance 0.08
The effect of apolipoprotein E genotype on neuron specific enolase and S-100beta levels after cardiac surgery.
Regulation (effect) of neuron specific enolase in neuron associated with disorder of lipid metabolism
12) Confidence 0.07 Published 2004 Journal Anesth. Analg. Section Title Doc Link 15502024 Disease Relevance 0.29 Pain Relevance 0.16
[Diagnostic value of s-100 protein and neuron-specific enolase as serum markers for cerebral deficiency after general anesthesia.
Regulation (value) of neuron-specific enolase in neuron associated with anesthesia
13) Confidence 0.06 Published 2000 Journal Anaesthesist Section Title Doc Link 11100253 Disease Relevance 0.09 Pain Relevance 0.10
The concentrations of neuron-specific enolase, hypoxanthine, creatine-kinase, lactate and pH in the CSF were determined before and immediately after surgery as well as 6 and 24 h after surgery.
Regulation (concentrations) of neuron-specific enolase in CSF
14) Confidence 0.04 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 14616329 Disease Relevance 0 Pain Relevance 0
The aim of the study was to compare changes in SEP and serum levels of S-100 beta protein and neuron-specific enolase (NSE) with perioperative clinical neurological deficits in patients undergoing regional anaesthesia (RA).
Regulation (changes) of neuron-specific enolase in neuron associated with rheumatoid arthritis
15) Confidence 0.04 Published 2007 Journal Zentralbl Chir Section Abstract Doc Link 17610185 Disease Relevance 0.19 Pain Relevance 0.07
The main purpose of this study was to investigate the prognostic value of serum neuron-specific enolase (NSE) in predicting outcomes in patients early after in-hospital cardiac arrest.


Spec (investigate) Regulation (value) of neuron-specific enolase in neuron associated with myocardial infarction
16) Confidence 0.03 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751053 Disease Relevance 0.62 Pain Relevance 0
Immunohistochemical staining is typically positive for S-100, Vimentin and Neuron-specific enolase.
Regulation (positive) of Neuron-specific enolase in Neuron
17) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2645401 Disease Relevance 1.27 Pain Relevance 0.08
S-100B and neuronal-specific enolase might, therefore, be potential markers of cerebral damage and BBB alterations in ARDS patients [28].
Regulation (alterations) of neuronal-specific enolase in neuronal associated with adult respiratory distress syndrome
18) Confidence 0.02 Published 2007 Journal Crit Care Section Body Doc Link PMC2206421 Disease Relevance 1.52 Pain Relevance 0.19
Formalin-fixed and paraffin-embedded pancreatic tissue was used as a positive control for synaptophysin, chromogranin, and neuron-specific enolase (NSE); hepatic tissue for alpha-fetoprotein (AFP) and Hep-Par1; and epidermis for cytokeratin.
Regulation (control) of neuron-specific enolase in neuron
19) Confidence 0.01 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950516 Disease Relevance 0.50 Pain Relevance 0.07
Immunohistochemistry showed positivity for synaptophysin, neuron specific enolase, chromogranin and cytokeratin.
Regulation (positivity) of neuron specific enolase in neuron
20) Confidence 0.01 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2092435 Disease Relevance 1.16 Pain Relevance 0.08

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