INT56835

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 1996
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1E) signal transducer activity (HTR1E)
Anatomy Link Frequency
brain 1
HTR1E (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 1 99.16 Very High Very High Very High
Potency 2 96.42 Very High Very High Very High
Sumatriptan 1 88.24 High High
agonist 4 82.24 Quite High
antagonist 1 77.64 Quite High
noradrenaline 3 75.00 Quite High
Desipramine 1 73.24 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 1 99.16 Very High Very High Very High
Disease 1 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory potency of the drugs was significantly correlated with their affinity for 5-HTID receptors in human brain and for cloned human 5-HT1D alpha and 5-HT1D beta receptors, but not with their affinity for 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT5B and 5-HT7 receptors.
5-HT1E Binding (affinity) of in brain associated with potency
1) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.48
Association of the HLA-A2, CW2, B27, S31, DR2 haplotype with ankylosing spondylitis.
S31 Binding (Association) of associated with spinal inflammation
2) Confidence 0.01 Published 1993 Journal Dis. Markers Section Title Doc Link 8112024 Disease Relevance 0.20 Pain Relevance 0.10

General Comments

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