INT56860

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Context Info
Confidence 0.17
First Reported 1994
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 12.39
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg) lipid metabolic process (Ugcg)
Anatomy Link Frequency
IB4 2
cardiac muscle 1
chondrocytes 1
brain 1
syncytiotrophoblast 1
Ugcg (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 404 99.74 Very High Very High Very High
Inflammation 57 98.40 Very High Very High Very High
cytokine 34 96.64 Very High Very High Very High
Inflammatory response 51 96.08 Very High Very High Very High
Pain 12 94.00 High High
cINOD 3 88.36 High High
Central nervous system 120 85.20 High High
Chronic pancreatitis 3 78.96 Quite High
medulla 26 77.80 Quite High
withdrawal 6 56.68 Quite High
Disease Link Frequency Relevance Heat
Infection 350 100.00 Very High Very High Very High
Solid Tumor 15 100.00 Very High Very High Very High
Cancer 144 99.84 Very High Very High Very High
Apoptosis 195 99.70 Very High Very High Very High
Neurocysticercosis 210 99.28 Very High Very High Very High
Stress 95 98.96 Very High Very High Very High
Brain Death 47 98.88 Very High Very High Very High
INFLAMMATION 118 98.40 Very High Very High Very High
Pulmonary Disease 2 97.88 Very High Very High Very High
Metastasis 3 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another possible explanation for the cell-type specific anti-apoptotic properties of GCs may be the differential expression of GR co-activators and co-repressors in diverse cell types, as proposed to explain the opposite effects of tamoxifen on mammary versus endometrial tissue [33].
Gene_expression (expression) of GCs associated with apoptosis
1) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.01 Pain Relevance 0.27
These new insights into GCS action may lead to new approaches to treating inflammatory lung diseases and in particular to increasing effectiveness of steroids in situations where they are less effective.
Gene_expression (action) of GCS in lung associated with pulmonary disease and inflammation
2) Confidence 0.15 Published 2005 Journal Immunol Allergy Clin North Am Section Abstract Doc Link 16054537 Disease Relevance 1.29 Pain Relevance 0.36
DEX and similar GCs were first introduced to tumour therapy on the basis of pro-apoptotic effects in lymphoid cells and on their effectiveness in treating tumour related edema, inflammation, pain, and electrolyte imbalance as well as stimulating appetite, and most importantly, preventing nausea and emesis caused by cytotoxic drugs [4-8].
Gene_expression (introduced) of GCs associated with pain, pressure and volume under development, inflammation, cancer, vomiting, apoptosis and dexamethasone
3) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.95 Pain Relevance 0.29
Concerns about the widespread use of GCs during therapy of solid tumours have been expressed repeatedly [9,10] involving studies showing enhanced percentages of metastases in breast cancer patients [11,12] or an increased risk of skin cancer and non-Hodgkin lymphomas among users of systemic GCs [13].
Gene_expression (expressed) of GCs in skin associated with lymphatic system cancer, breast cancer, solid tumor, skin cancer and metastasis
4) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.86 Pain Relevance 0.29
It has been shown that the glycosidic portion of glycoproteins and other glycoconjugates (GCs) expressed by T. solium metacestodes are highly antigenic, being recognized by serum from infected patients and mainly studied as potential targets in serological diagnosis [14],[16],[19].
Gene_expression (expressed) of GCs
5) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.57 Pain Relevance 0.07
In the NCC samples analyzed, parasite-derived GCs were detected in numerous cells surrounding the parasites.
Gene_expression (detected) of GCs associated with neurocysticercosis
6) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.62 Pain Relevance 0.03
The rapid release of tegument material upon host penetration correlated with the loss of IB4 bound GCs and associates with the reduced number of discoidal bodies and mitochondria.
Gene_expression (bound) of GCs in IB4
7) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.06 Pain Relevance 0.08
In contrast to the early disappearance of IB4 bound GCs, WGA bound GCs present in the tegument before infection were detected during several previously characterized stages of murine, porcine and human NCC.
Gene_expression (bound) of GCs in IB4 associated with neurocysticercosis and infection
8) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.70 Pain Relevance 0
In order to validate the data obtained with M. corti, skeletal and cardiac muscle samples representative of different stages of infection in pigs [6],[25] were used to determine the GCs present in the tegument of T. solium and their changes during host-parasite interaction.
Spec (determine) Gene_expression (present) of GCs in cardiac muscle associated with infection
9) Confidence 0.10 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.48 Pain Relevance 0
GCs elicit IL-10, TGF-?
Gene_expression (elicit) of GCs
10) Confidence 0.10 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 1.00 Pain Relevance 0.22
IHC demonstrated that COX-2 expression is low (level 1) within the syncytiotrophoblast, spongiotrophoblast and GCs at E14.
Gene_expression (expression) of GCs in syncytiotrophoblast
11) Confidence 0.10 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.14 Pain Relevance 0
While endogenous GCs have been shown to promote the differentiation of both chondrocytes and osteoblasts, exogenous GCs in pharmacological doses which are also widely used in clinical practice to treat inflammatory disorders [41-46].
Gene_expression (exogenous) of GCs in chondrocytes associated with inflammation
12) Confidence 0.10 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.26 Pain Relevance 0.05
At E14 COX-1 immunoreactivity was not observed in any cell type, except for low intensity (level 1) staining in the GCs.
Neg (except) Gene_expression (staining) of GCs
13) Confidence 0.10 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.08 Pain Relevance 0
GCs bound by isolectinB4 were shed in the first days of infection and not resynthesized by the parasite, whereas GCs bound by wheat germ agglutinin and concavalinA were continuously released throughout the infectious process.
Neg (not) Gene_expression (resynthesized) of GCs associated with infection
14) Confidence 0.09 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2274955 Disease Relevance 0.77 Pain Relevance 0.12
Using the GCS, the patient with imminent brain death has no eye movement (E1), no motor response (M1) and no verbal response (V1).
Gene_expression (Using) of GCS in brain associated with brain death
15) Confidence 0.05 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2921050 Disease Relevance 1.00 Pain Relevance 0.12
While endogenous GCs have been shown to promote the differentiation of both chondrocytes and osteoblasts, exogenous GCs in pharmacological doses which are also widely used in clinical practice to treat inflammatory disorders [41-46].
Gene_expression (exogenous) of GCs in osteoblasts associated with inflammation
16) Confidence 0.03 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.26 Pain Relevance 0.05
We also observed that the onset of the change of expression of different genes differed, e.g. the expression of GCS-HC increased 2 folds at 4 h, but the increase of HO-1 mRNA did not occur until 16 h.


Gene_expression (expression) of GCS-HC
17) Confidence 0.02 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.07 Pain Relevance 0.03
The concentration of total collagen (hydroxyproline [Hyp]), the activities of the two key enzymes in collagen biosynthesis (prolyl 4-hydroxylase [PH] and galactosylhydroxylysyl glucosyltransferase [GGT]), and the concentration of mature collagen crosslinks (hydroxypyridinium [HP]) were determined.
Gene_expression (biosynthesis) of galactosylhydroxylysyl glucosyltransferase
18) Confidence 0.00 Published 1994 Journal J. Orthop. Res. Section Abstract Doc Link 8113947 Disease Relevance 0.29 Pain Relevance 0.07

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