INT56864

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.03
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 122 100.00 Very High Very High Very High
Kinase C 1 100.00 Very High Very High Very High
antagonist 19 99.96 Very High Very High Very High
Neuropathic pain 4 98.24 Very High Very High Very High
Morphine 15 98.20 Very High Very High Very High
Hyperalgesia 3 96.88 Very High Very High Very High
Opioid 9 94.04 High High
medulla 27 77.88 Quite High
narcan 3 76.40 Quite High
Pain 2 75.76 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 99.74 Very High Very High Very High
Hyperalgesia 3 96.88 Very High Very High Very High
Ganglion Cysts 1 92.80 High High
Pain 2 75.76 Quite High
Anxiety Disorder 1 59.32 Quite High
Appetite Loss 1 49.76 Quite Low
Body Weight 2 45.44 Quite Low
Aids-related Complex 5 40.36 Quite Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of either cholecystokinin receptor subtype reduces while antagonists potentiate or sensitize a morphine-induced excitatory response.
Negative_regulation (reduces) of Positive_regulation (Stimulation) of cholecystokinin associated with antagonist, cholecystokinin and morphine
1) Confidence 0.43 Published 2001 Journal Peptides Section Title Doc Link 11457524 Disease Relevance 0 Pain Relevance 0.67
In contrast, 3R[+]-N-[2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-benzodiazepin-3-yl ]-N'- [3-methyl-phenyl]urea (L365,260), a selective CCKB receptor antagonist, blocked the action of CCK4(30-33) and SNF 9007 (phase I), and also antagonized CCK8(s), though to a lesser degree.
Negative_regulation (blocked) of Positive_regulation (action) of CCK4 associated with antagonist
2) Confidence 0.43 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113956 Disease Relevance 0 Pain Relevance 0.30
The action of CCK on CART expression was shown to be mediated by activation of protein kinase C and cAMP response element binding protein (CREB) and was inhibited by orexigenic ghrelin [25].
Negative_regulation (inhibited) of Positive_regulation (action) of CCK associated with kinase c and cholecystokinin
3) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.15 Pain Relevance 0.73
Induction of neuropathy resulted in decrease of lumbar pro-opiomelanocortin (POMC) gene expression in wild-type mice, but increase of POMC expression in CCK(2) (-/-) mice.
Negative_regulation (decrease) of Positive_regulation (increase) of CCK associated with neuropathic pain and cholecystokinin
4) Confidence 0.38 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15355324 Disease Relevance 0.88 Pain Relevance 1.77

General Comments

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