INT56883

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 3.49
Pain Relevance 12.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dll1) cell-cell signaling (Dll1)
Anatomy Link Frequency
nucleus accumbens 1
spinal 1
spinal cord 1
neurons 1
lateral 1
Dll1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 7 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
cocaine 1 100.00 Very High Very High Very High
opioid receptor 23 99.96 Very High Very High Very High
MU agonist 11 99.96 Very High Very High Very High
dorsal root ganglion 16 99.84 Very High Very High Very High
Spinal cord 6 99.68 Very High Very High Very High
Calcium channel 8 99.66 Very High Very High Very High
allodynia 8 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Eating Disorder 3 99.82 Very High Very High Very High
Neuropathic Pain 28 99.54 Very High Very High Very High
Coronary Artery Disease 1 99.44 Very High Very High Very High
Ganglion Cysts 16 99.36 Very High Very High Very High
Hyperalgesia 2 97.72 Very High Very High Very High
Cv Unclassified Under Development 1 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic food restriction in rats augments the central rewarding effect of cocaine and the delta1 opioid agonist, DPDPE, but not the delta2 agonist, deltorphin-II.
Positive_regulation (augments) of delta1 associated with mu agonist, agonist, eating disorder and cocaine
1) Confidence 0.49 Published 2000 Journal Psychopharmacology (Berl.) Section Title Doc Link 11057524 Disease Relevance 0.20 Pain Relevance 0.45
This study provides evidence that not only activation of delta1- and delta2-opioid receptors, but also activation of mu-opioid receptors in the nucleus accumbens increases the release of accumbal dopamine in freely moving rats.
Positive_regulation (activation) of delta1 in nucleus accumbens associated with nucleus accumbens, dopamine, mu opioid receptor and opioid receptor
2) Confidence 0.44 Published 1999 Journal Neuroscience Section Abstract Doc Link 10426490 Disease Relevance 0 Pain Relevance 1.52
These findings suggest that: 1) DELT and DPDPE act at different delta opioid receptor subtypes in the rat spinal cord; 2) 3 micrograms of NTB can distinguish these receptor subtypes and 3) activation of either delta-1 or delta-2 receptors is sufficient to produce antinociception in the tail-flick test.
Positive_regulation (activation) of delta-1 in tail associated with antinociception, tail-flick, opioid receptor and spinal cord
3) Confidence 0.33 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8394918 Disease Relevance 0 Pain Relevance 0.90
Chronic PGB treatment of SNL animals, at a dose that alleviated allodynia, markedly reduced the elevation of alpha(2)delta-1 in the spinal cord and ascending axon tracts.
Positive_regulation (elevation) of delta-1 in spinal cord associated with pregabalin, allodynia, spinal nerve ligature and spinal cord
4) Confidence 0.30 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19339603 Disease Relevance 0.74 Pain Relevance 1.75
The calcium channel subunit alpha(2)delta-1 is upregulated in dorsal root ganglion (DRG) neurons in several animal models of neuropathic pain, and this is causally related to the onset of allodynia, in which a non-noxious stimulus becomes painful.
Positive_regulation (upregulated) of delta-1 in neurons associated with ganglion cysts, pain, dorsal root ganglion, allodynia, calcium channel and neuropathic pain
5) Confidence 0.30 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19339603 Disease Relevance 0.68 Pain Relevance 1.16
We found that, on the side of the ligation, alpha(2)delta-1 was increased in the endoplasmic reticulum of DRG somata, in intracellular vesicular structures within their axons, and in the plasma membrane of their presynaptic terminals in superficial layers of the dorsal horn.
Positive_regulation (increased) of delta-1 in dorsal horn associated with dorsal root ganglion and dorsal horn
6) Confidence 0.30 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19339603 Disease Relevance 0.81 Pain Relevance 1.65
In contrast, it had no effect on the upregulation of alpha(2)delta-1 mRNA and protein in DRGs.
Positive_regulation (upregulation) of delta-1
7) Confidence 0.30 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19339603 Disease Relevance 0.70 Pain Relevance 1.72
Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat.
Positive_regulation (Activation) of delta-1 in spinal associated with hyperalgesia, enkephalin and opioid receptor
8) Confidence 0.25 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8113981 Disease Relevance 0.19 Pain Relevance 0.76
Endogenous activation of mu and delta-1 opioid receptors is required for long-term potentiation induction in the lateral perforant path: dependence on GABAergic inhibition.
Positive_regulation (activation) of delta-1 in lateral associated with addiction, gabaergic, long-term potentiation and opioid receptor
9) Confidence 0.19 Published 1996 Journal J. Neurosci. Section Title Doc Link 8987837 Disease Relevance 0 Pain Relevance 0.99
Thus, these data further implicate mu, delta1, and delta2 opioid mediation of palatable intake, particularly of its orosensory characteristics.
Positive_regulation (mediation) of delta1 associated with opioid
10) Confidence 0.17 Published 1997 Journal Physiol. Behav. Section Abstract Doc Link 9226351 Disease Relevance 0 Pain Relevance 0.89
[Antiarrhythmic and cardioprotective effect of stimulation of delta1-opiate receptors in myocardial ischemia and reperfusion].
Positive_regulation (stimulation) of delta1-opiate associated with coronary artery disease, ischemia and opiate
11) Confidence 0.09 Published 2004 Journal Patol Fiziol Eksp Ter Section Title Doc Link 15446414 Disease Relevance 0.18 Pain Relevance 0.46

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