INT56884

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.15
Pain Relevance 8.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dll1) cell-cell signaling (Dll1)
Anatomy Link Frequency
plasma 1
spinal 1
spinal cord 1
tail 1
Dll1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 33 100.00 Very High Very High Very High
agonist 32 100.00 Very High Very High Very High
medulla 9 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
Spinal cord 7 100.00 Very High Very High Very High
antinociception 30 99.96 Very High Very High Very High
antagonist 4 99.52 Very High Very High Very High
pregabalin 6 99.50 Very High Very High Very High
Enkephalin 13 99.18 Very High Very High Very High
Delta opioid receptors 6 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 90.76 High High
Urological Neuroanatomy 4 85.00 Quite High
Ganglion Cysts 4 81.16 Quite High
Colon Cancer 6 80.60 Quite High
Apoptosis 2 79.76 Quite High
Low Back Pain 2 76.00 Quite High
Hyperalgesia 2 75.00 Quite High
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The difference in the nature of the interaction produced by delta1 and delta2 opioid receptor agonists provides additional evidence for the existence of different subtypes of the delta opioid receptor.
Gene_expression (produced) of delta1 associated with agonist and opioid receptor
1) Confidence 0.48 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215679 Disease Relevance 0 Pain Relevance 1.51
This study used isobolographic analysis to determine how delta1 and delta2 opioid receptors in the VMM interact with their respective receptors in the spinal cord to produce antinociception.
Gene_expression (produce) of delta1 in spinal cord associated with antinociception, medulla, opioid receptor and spinal cord
2) Confidence 0.48 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215679 Disease Relevance 0 Pain Relevance 1.30
Pretreatments (24 h prior to agonist microinjection) were made with the putative delta1 and delta2 antagonists, [D-Ala2,Leu5,Cys6]enkephalin (DALCE) and [D-Ala2,Cys4]deltorphin (Cys-DELT) and antinociception was measured in the 55 degrees C hot plate (HP) and 52 degrees C and 55 degrees C (low and high intensity) warm-water tail-flick (TF) tests.
Gene_expression (made) of delta1 in tail associated with antinociception, antagonist, tail-flick, agonist and enkephalin
3) Confidence 0.47 Published 1995 Journal Pain Section Abstract Doc Link 8657428 Disease Relevance 0.22 Pain Relevance 1.72
Interaction between medullary and spinal delta1 and delta2 opioid receptors in the production of antinociception in the rat.
Gene_expression (production) of delta1 in spinal associated with antinociception, enkephalin and opioid receptor
4) Confidence 0.42 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10215679 Disease Relevance 0 Pain Relevance 1.28
In vitro, PGB reduced plasma membrane expression of alpha(2)delta-1 without affecting endocytosis.
Gene_expression (expression) of delta-1 in plasma associated with pregabalin
5) Confidence 0.33 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19339603 Disease Relevance 0.61 Pain Relevance 1.64
The difference between the 2 measurements for the first rehabilitation program was expressed as Delta1 and for the second as Delta2; the comparison between Delta1 and Delta2 for each outcome measure was taken into account.
Gene_expression (expressed) of Delta1
6) Confidence 0.25 Published 2006 Journal J. Rheumatol. Section Body Doc Link 17014018 Disease Relevance 0.08 Pain Relevance 0
Thus, although NTB distinguishes between delta-1 and delta-2 opioid receptors, high doses may not effectively distinguish between delta and mu receptors.
Gene_expression (distinguishes) of delta-1 associated with opioid receptor
7) Confidence 0.24 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113981 Disease Relevance 0.07 Pain Relevance 0.43
The present study determined if specific delta1, delta2, kappa1, kappa3 and mu opioid-receptor subtype agonists produced similar alterations in sucrose intake as a function of sucrose concentration (0.5%, 2.5%, 10%) across a 1-h time-course.
Gene_expression (produced) of delta1 associated with agonist and opioid
8) Confidence 0.23 Published 1997 Journal Physiol. Behav. Section Abstract Doc Link 9226351 Disease Relevance 0 Pain Relevance 1.10
The expression of the Notch1, Delta1, ICN, Hes1 and NF-kappaB2 proteins was measured by Western blot.
Gene_expression (expression) of Delta1
9) Confidence 0.04 Published 2008 Journal Dig. Dis. Sci. Section Body Doc Link 18320325 Disease Relevance 0.16 Pain Relevance 0

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