INT569

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Context Info
Confidence 0.42
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 9.48
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4a) extracellular region (C4a) molecular_function (C4a)
Anatomy Link Frequency
plasma 1
liver 1
spinal cord 1
respiratory 1
C4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 100.00 Very High Very High Very High
Kinase C 2 100.00 Very High Very High Very High
depression 2 100.00 Very High Very High Very High
Clonidine 1 99.04 Very High Very High Very High
peripheral neuropathy 2 97.94 Very High Very High Very High
Cholecystokinin 5 97.80 Very High Very High Very High
anesthesia 5 96.12 Very High Very High Very High
Raphe 5 94.60 High High
bradykinin 1 93.84 High High
Inflammation 43 92.48 High High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Spinal Cord Injury 2 100.00 Very High Very High Very High
Cryoglobulinemia 6 99.30 Very High Very High Very High
Disease 218 98.92 Very High Very High Very High
Increased Venous Pressure Under Development 22 98.88 Very High Very High Very High
Anaemia 7 98.48 Very High Very High Very High
Hematuria 3 98.32 Very High Very High Very High
Schnitzler Syndrome 64 98.24 Very High Very High Very High
Hyperplasia 2 98.20 Very High Very High Very High
Systemic Lupus Erythematosus 56 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pancreatic responses were completely abolished by spinal cord transection at the level between C4 and C5.
Negative_regulation (abolished) of C4 in spinal cord associated with spinal cord
1) Confidence 0.42 Published 1995 Journal Pancreas Section Abstract Doc Link 7792298 Disease Relevance 0.18 Pain Relevance 0.36
Long-lasting depression of the respiratory rhythm (C4 and Pre-I activity) by clonidine, which might decrease intracellular cAMP level via alpha 2-receptors, was reversed by forskolin.
Negative_regulation (depression) of C4 in respiratory associated with depression and clonidine
2) Confidence 0.33 Published 1993 Journal Brain Res. Section Abstract Doc Link 7683235 Disease Relevance 0.19 Pain Relevance 0.36
The diagnosis can be confirmed by finding low levels of C1 esterase inhibitor, C4 and C2.
Negative_regulation (inhibitor) of C4
3) Confidence 0.25 Published 1992 Journal J Assoc Physicians India Section Abstract Doc Link 1452538 Disease Relevance 0.63 Pain Relevance 0.09
The relative increase in serum C3 protein and decrease in C4 protein could explain changes in the C3/C4 ratio.
Negative_regulation (decrease) of C4
4) Confidence 0.19 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17398178 Disease Relevance 0.31 Pain Relevance 0.05
Most patients have decreased plasma complement protein C4 levels.
Negative_regulation (decreased) of C4 in plasma
5) Confidence 0.14 Published 2008 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 18241690 Disease Relevance 0.84 Pain Relevance 0.12
Subsequently, total hemolytic activity (CH50) levels were variable, complement component protein concentrations of C1q, C1s, C4, C2, C3, C5, C6, C9, and Factor B were normal, but hemolytic activity of C4 and C2 was diminished.
Negative_regulation (diminished) of C4
6) Confidence 0.08 Published 1975 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 50336 Disease Relevance 0.31 Pain Relevance 0.38
CCK's secretagogue effect was independent of electrical stimulation and extracellular Ca2+ and was blocked by an inhibitor of protein kinase C. 4.
Negative_regulation (inhibitor) of C. 4 associated with kinase c and cholecystokinin
7) Confidence 0.08 Published 1989 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2575930 Disease Relevance 0 Pain Relevance 0.50
Laboratory findings revealed proteinuria, hematuria, anemia, leucopenia, a high titer of antinuclear antibodies (ANA), anti-dsDNA, and decreased complement (C3 and C4) levels.
Negative_regulation (decreased) of C4 associated with anaemia, proteinuria and hematuria
8) Confidence 0.07 Published 2010 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 20054604 Disease Relevance 1.62 Pain Relevance 0.09
A longitudinal study is needed to determine whether there is an association between a reduction in C4 levels and an increase in disease activity in SLE as measured by the BILAG-2004 index.
Spec (whether) Negative_regulation (reduction) of C4 associated with systemic lupus erythematosus and disease
9) Confidence 0.06 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.54 Pain Relevance 0
In both groups of patients the serum concentrations of C3, C4, C5, and C1 inhibitor were significantly affected by the treatments (p < 0.001), decreased immediately after onset of anesthesia, were minimal during surgery, and increased thereafter.
Negative_regulation (inhibitor) of C4 associated with anesthesia
10) Confidence 0.04 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.13
Increasing overall scores on the BILAG-2004 index were associated with increasing ESRs, decreasing C3 levels, decreasing C4 levels, elevated anti-dsDNA levels, and increasing SLEDAI-2K scores (all P < 0.01).
Negative_regulation (decreasing) of C4
11) Confidence 0.04 Published 2007 Journal Arthritis and Rheumatism Section Abstract Doc Link PMC2659367 Disease Relevance 0.66 Pain Relevance 0
Subsequently, total hemolytic activity (CH50) levels were variable, complement component protein concentrations of C1q, C1s, C4, C2, C3, C5, C6, C9, and Factor B were normal, but hemolytic activity of C4 and C2 was diminished.
Negative_regulation (diminished) of C4
12) Confidence 0.04 Published 1975 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 50336 Disease Relevance 0.30 Pain Relevance 0.37
When complement levels are lowered, another diagnosis must be considered, especially hypocomplementic urticarial vasculitis and cryoglobulinemia, and the possibility of a genetic deficiency of C4 should be addressed, since 2 patients with Schnitzler syndrome had a C4a deficiency [42].
Negative_regulation (deficiency) of C4 associated with cryoglobulinemia, increased venous pressure under development and schnitzler syndrome
13) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018454 Disease Relevance 1.49 Pain Relevance 0.09
Associated findings include pseudoxanthum elasticum in 2 patients [44,45], peripheral neuropathy with the presence of monoclonal IgM with anti-MAG (myelin-associated glycoprotein) in 1 patient [46], C4 deficiency in 2 patients [42] and nodular regenerative hyperplasia of the liver in 1 patient [47], impairment of renal function in 1 patient [48], thrombophilia with anti-phospholipid antibodies and hyperhomocysteinemia [49] and hearing loss [3].
Negative_regulation (deficiency) of C4 in liver associated with deafness, thrombophilia, peripheral neuropathy, hyperhomocysteinemia and hyperplasia
14) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018454 Disease Relevance 2.06 Pain Relevance 0.18
The concentration of routine laboratory parameters, components of the complement system (C3, C4, C5, C1 inhibitor, total hemolytic complement, C3d, and C5a), circulating interleukins (IL-6 and IL-8) and soluble adhesion molecules (sICAM-1 and sE-selectin) were determined.
Negative_regulation (inhibitor) of C4 associated with adhesions
15) Confidence 0.02 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.11

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