INT5690

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 36
Total Number 36
Disease Relevance 8.29
Pain Relevance 24.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 8
striatum 5
caudate nucleus 4
NG108-15 4
hippocampus 4
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 153 100.00 Very High Very High Very High
Opioid 102 100.00 Very High Very High Very High
Buprenorphine 96 100.00 Very High Very High Very High
narcan 30 100.00 Very High Very High Very High
mu opioid receptor 7 100.00 Very High Very High Very High
MU agonist 5 100.00 Very High Very High Very High
withdrawal 36 99.98 Very High Very High Very High
tricyclic antidepressant 6 99.98 Very High Very High Very High
poststroke pain 6 99.90 Very High Very High Very High
Analgesic 10 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 9 100.00 Very High Very High Very High
Stress 6 99.98 Very High Very High Very High
Sleep Disorders 5 99.98 Very High Very High Very High
Pain 24 99.90 Very High Very High Very High
Convulsion 4 99.82 Very High Very High Very High
Neuropathic Pain 12 98.96 Very High Very High Very High
Shock 12 98.76 Very High Very High Very High
Sudden Infant Death Syndrome 9 98.72 Very High Very High Very High
Drug Dependence 7 98.64 Very High Very High Very High
Disease 12 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated restraint stress reduces opioid receptor binding in different rat CNS structures.
Negative_regulation (reduces) of opioid receptor Binding (binding) of associated with stress, narcan and opioid receptor
1) Confidence 0.59 Published 2005 Journal Neurochem. Res. Section Title Doc Link 15756926 Disease Relevance 0.55 Pain Relevance 0.50
Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study.
Negative_regulation (reduced) of opioid receptor Binding (binding) of associated with pain, opioid receptor and poststroke pain
2) Confidence 0.56 Published 2004 Journal Pain Section Title Doc Link 15030940 Disease Relevance 0.56 Pain Relevance 1.06
Low affinity inhibition of opioid receptor binding by FMRFamide.
Negative_regulation (inhibition) of opioid receptor Binding (binding) of associated with opioid receptor
3) Confidence 0.55 Published 1986 Journal Neuropeptides Section Title Doc Link 3020469 Disease Relevance 0 Pain Relevance 0.48
Altered microviscosity at brain membrane surface induces distinct and reversible inhibition of opioid receptor binding.
Negative_regulation (inhibition) of opioid receptor Binding (binding) of in brain associated with opioid receptor
4) Confidence 0.49 Published 1992 Journal J. Neurochem. Section Title Doc Link 1328516 Disease Relevance 0 Pain Relevance 0.29
Moderate-high doses of buprenorphine may be acting on a functionally related binding site which non-competitively inhibits the usual buprenorphine-mu opioid receptor interaction.
Negative_regulation (inhibits) of opioid receptor Binding (interaction) of associated with mu opioid receptor and buprenorphine
5) Confidence 0.43 Published 1992 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1623635 Disease Relevance 0 Pain Relevance 0.79
Thus, the result of this study did not suggest that alteration in transcription of gene-encoding delta-opioid receptor was responsible for the down-regulation of delta-opioid receptor associated with the development of tolerance to DADLE.
Negative_regulation (down-regulation) of delta-opioid receptor Binding (associated) of associated with tolerance and opioid receptor
6) Confidence 0.43 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.64
The present study suggests that there is not a defect in opioid receptor binding in cardiorespiratory nuclei in SIDS brainstems.
Negative_regulation (defect) of opioid receptor Binding (binding) of in brainstems associated with sudden infant death syndrome and opioid receptor
7) Confidence 0.41 Published 1998 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 9696272 Disease Relevance 0.43 Pain Relevance 0.42
Naltrexone, on the other hand, works by preventing the positive reinforcement of administered opioids by preventing them from binding to the opioid receptor.
Negative_regulation (preventing) of opioid receptor Binding (binding) of associated with opioid receptor and opioid
8) Confidence 0.40 Published 1988 Journal J Psychoactive Drugs Section Abstract Doc Link 3069983 Disease Relevance 0.28 Pain Relevance 0.97
However, the binding density of mu- and delta-opioid receptors differed slightly in several brain areas: in the AA brain sections, limbic areas, such as hippocampus and amygdala, showed decreased mu- and delta-opioid receptor binding, whereas the striatal patches were larger and the substantia nigra showed higher binding density of the mu-receptors compared to the ANA sections.
Negative_regulation (decreased) of opioid receptor Binding (binding) of in brain associated with substantia nigra, opioid receptor, hippocampus, delta opioid receptors, amygdala and alcohol
9) Confidence 0.37 Published 1998 Journal Alcohol Section Abstract Doc Link 9539380 Disease Relevance 0 Pain Relevance 0.97
Sleep deprivation decreases mu and delta opioid receptor binding in the rat limbic system.
Negative_regulation (decreases) of opioid receptor Binding (binding) of associated with enkephalin, opioid receptor and limbic system
10) Confidence 0.37 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 1660582 Disease Relevance 0.29 Pain Relevance 0.52
Butorphanol dependence and withdrawal decrease hippocampal kappa 2-opioid receptor binding.
Negative_regulation (decrease) of opioid receptor Binding (binding) of associated with addiction, butorphanol, opioid receptor and withdrawal
11) Confidence 0.35 Published 2002 Journal Brain Res. Section Title Doc Link 12470863 Disease Relevance 0.06 Pain Relevance 1.26
Other interactions between progesterone and neurotransmitter systems include stimulation of dopamine release in striatal tissue, stimulation of GnRH release from hypothalamic neurons and inhibition of opioid receptor binding and activation.
Negative_regulation (inhibition) of opioid receptor Binding (binding) of in neurons associated with dopamine, neurotransmitter and opioid receptor
12) Confidence 0.35 Published 2003 Journal Maturitas Section Abstract Doc Link 14670648 Disease Relevance 0.20 Pain Relevance 0.49
Specific reduction of delta-opioid receptor binding in transfected NG108-15 cells.
Negative_regulation (reduction) of opioid receptor Binding (binding) of in NG108-15 associated with opioid receptor
13) Confidence 0.33 Published 1992 Journal J. Biol. Chem. Section Title Doc Link 1313812 Disease Relevance 0.26 Pain Relevance 0.27
When the relative decrease in mu and delta opioid receptor binding was determined by carrying out [3H]-D-Ala2, DLeu5-enkephalin binding in the presence of 1 microM morphiceptin, it was observed that, 3 days after etorphine treatment, there was a decrease in mu opioid receptor binding, with minimal change in delta opioid receptor binding in both brain regions of striatum and midbrain.
Negative_regulation (decrease) of opioid receptor Binding (binding) of in striatum associated with mu opioid receptor, midbrain, enkephalin, opioid receptor and immobilon
14) Confidence 0.32 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3031275 Disease Relevance 0 Pain Relevance 1.04
Our conclusion is that chronic DPDPE treatment preferentially reduces delta-opioid receptor binding activity.
Negative_regulation (reduces) of delta-opioid receptor Binding (activity) of associated with opioid receptor
15) Confidence 0.32 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1665782 Disease Relevance 0 Pain Relevance 0.54
When [3H]DADLE binding was carried out in the presence of morphiceptin, a significant reduction in the delta-opioid receptor binding was observed in all brain areas tested. mu-Opioid receptor binding decrease was observed only in the striatum after 5 days of DADLE treatment.
Negative_regulation (reduction) of delta-opioid receptor Binding (binding) of in striatum associated with opioid receptor
16) Confidence 0.31 Published 1988 Journal Brain Res. Section Abstract Doc Link 2847851 Disease Relevance 0 Pain Relevance 0.78
Ten consecutive daily electroconvulsive shocks (ECSs), which produce maximal tonic and clonic convulsions, caused reductions of mu- and delta-opioid receptor binding in the hypothalamus, hippocampus and caudate nucleus, but not in the frontal cortex and brainstem.
Negative_regulation (reductions) of opioid receptor in hypothalamus Binding (binding) of in caudate nucleus associated with medulla, convulsion, shock, urological neuroanatomy, hippocampus and opioid receptor
17) Confidence 0.30 Published 1985 Journal Brain Res. Section Abstract Doc Link 2996704 Disease Relevance 0.53 Pain Relevance 0.26
When mu- and delta-binding was determined using [3H]diprenorphine in the presence of morphiceptin or DPDPE respectively, a significant decrease (20-30%) in the mu-opioid receptor binding but not in delta-opioid receptor binding was observed in all the brain areas tested after 5 days of PL017 treatment.
Negative_regulation (decrease) of delta-opioid receptor Binding (binding) of in brain associated with opioid receptor
18) Confidence 0.28 Published 1990 Journal Brain Res. Section Abstract Doc Link 2175241 Disease Relevance 0.09 Pain Relevance 0.58
Increases in availability of opioid peptides will then result in decreased opioid receptor binding.
Negative_regulation (decreased) of opioid receptor Binding (binding) of associated with opioid receptor and opioid
19) Confidence 0.24 Published 1995 Journal Brain Res. Section Abstract Doc Link 7663971 Disease Relevance 0 Pain Relevance 0.46
Mutation of Trp318 decreased opioid receptor binding to almost undetectable levels.
Negative_regulation (decreased) of opioid receptor Binding (binding) of associated with opioid receptor
20) Confidence 0.15 Published 1999 Journal Synapse Section Abstract Doc Link 10188634 Disease Relevance 0.07 Pain Relevance 0.81

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