INT56912

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Context Info
Confidence 0.33
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.75
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefm) cytoskeleton (Nefm)
Anatomy Link Frequency
brain 1
SHED 1
stem cells 1
cortex 1
Nefm (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 95.84 Very High Very High Very High
Kappa opioid receptor 4 93.64 High High
Opioid 1 91.52 High High
antagonist 4 90.96 High High
Inflammation 18 88.68 High High
narcan 2 87.44 High High
Hippocampus 12 86.96 High High
MU agonist 1 79.76 Quite High
IPN 1 52.48 Quite High
Central nervous system 3 9.44 Low Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 2 100.00 Very High Very High Very High
Obesity 4 96.64 Very High Very High Very High
Motor Neuron Diseases 107 96.02 Very High Very High Very High
Nociception 1 89.52 High High
INFLAMMATION 27 88.68 High High
Systemic Lupus Erythematosus 64 78.72 Quite High
Alzheimer's Dementia 2 75.00 Quite High
Disease 40 74.48 Quite High
Graft Vs Host Disease 4 74.48 Quite High
Neurodegenerative Disease 9 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As neural crest cell-associated postnatal stem cells, SHED express a variety of neural cell markers including nestin, beta III tubulin, GAD, NeuN, GFAP, NFM, and CNPase [21].
Gene_expression (express) of NFM in stem cells associated with generalized anxiety disorder
1) Confidence 0.33 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.77 Pain Relevance 0
Our analysis reveals the alteration of two major components of the neuronal cytoskeleton in the ALS motor cortex at the mRNA level, showing a general down-regulation of microtubules by pathway-based analysis and deregulation of two genes encoding tubulin beta (TUBB2A, TUBB6), as well as decreased expression of all three neurofilament subunits (NEFL, NEF3, NEFH).
Gene_expression (expression) of NEF3 in cortex associated with motor neuron diseases
2) Confidence 0.23 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.84 Pain Relevance 0
As neural crest cell-associated postnatal stem cells, SHED express a variety of neural cell markers including nestin, beta III tubulin, GAD, NeuN, GFAP, NFM, and CNPase [21].
Gene_expression (express) of NFM in SHED associated with generalized anxiety disorder
3) Confidence 0.11 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.77 Pain Relevance 0
It also promoted the expression of the 200,000 mol. wt neurofilament protein, this became pronounced after two to three days.
Gene_expression (expression) of neurofilament protein
4) Confidence 0.01 Published 1993 Journal Neuroscience Section Abstract Doc Link 8115050 Disease Relevance 0 Pain Relevance 0.59
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Gene_expression (levels) of neurofilament-70 in brain
5) Confidence 0.00 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.37 Pain Relevance 0.21

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