INT56916

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Context Info
Confidence 0.10
First Reported 1994
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.14
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mesangium 2
Mir125b-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 12 99.80 Very High Very High Very High
Morphine 27 99.36 Very High Very High Very High
alcohol 12 99.08 Very High Very High Very High
addiction 5 81.12 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 2 81.12 Quite High
Focal Segmental Glomerulosclerosis 2 78.36 Quite High
Injury 11 78.04 Quite High
Opiate Addiction 3 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we studied the effect of cocaine, alcohol, and morphine alone or in combination on the accumulation of radiolabeled human immunoglobulin-G (IgG) aggregates (AHIgG125I) into glomeruli/mesangium.
Positive_regulation (accumulation) of AHIgG125I in mesangium associated with morphine, alcohol and cocaine
1) Confidence 0.10 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115348 Disease Relevance 0.16 Pain Relevance 1.00
Cocaine enhanced accumulation of AHIgG125I at 8 hr.
Positive_regulation (accumulation) of AHIgG125I associated with cocaine
2) Confidence 0.09 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115348 Disease Relevance 0.15 Pain Relevance 1.02
At 4 h, ATS-treated rats showed a lower (p < 0.02) accumulation of AHIgG125I in the mesangium when compared with control rats (controls 511,012 +/- 10,807 vs.
Positive_regulation (accumulation) of AHIgG125I in mesangium
3) Confidence 0.04 Published 1996 Journal Nephron Section Abstract Doc Link 8883040 Disease Relevance 0.30 Pain Relevance 0.35
ATS plus morphine treated rats showed a higher (p < 0.01) accumulation of of AHIgG125I when compared with rats treated with AS alone.
Positive_regulation (accumulation) of AHIgG125I associated with morphine
4) Confidence 0.04 Published 1996 Journal Nephron Section Abstract Doc Link 8883040 Disease Relevance 0.27 Pain Relevance 0.42
Even at 24, h morphine-treated ATS rats showed a higher accumulation of AHIgG125I when compared with those treated with ATS alone.
Positive_regulation (accumulation) of AHIgG125I associated with morphine
5) Confidence 0.04 Published 1996 Journal Nephron Section Abstract Doc Link 8883040 Disease Relevance 0.26 Pain Relevance 0.42

General Comments

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