INT56918

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.92
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TAT) mitochondrion (TAT) small molecule metabolic process (TAT)
biosynthetic process (TAT) cellular nitrogen compound metabolic process (TAT) cellular_component (TAT)
Anatomy Link Frequency
plasma 3
PGE1 1
neurons 1
TAT (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 6 99.84 Very High Very High Very High
aspirin 15 99.82 Very High Very High Very High
Angina 15 99.40 Very High Very High Very High
Pain 2 98.20 Very High Very High Very High
Restless leg syndrome 2 79.12 Quite High
cytokine 2 73.56 Quite High
abdominal pain 2 64.20 Quite High
anesthesia 4 63.80 Quite High
Freund adjuvant 4 59.00 Quite High
epidural 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Tyrosinemia 14 99.48 Very High Very High Very High
Cv General 3 Under Development 15 99.40 Very High Very High Very High
Toxicity 4 99.08 Very High Very High Very High
Keratitis 1 96.08 Very High Very High Very High
Death 7 95.92 Very High Very High Very High
Peripheral Arterial Disease 4 95.64 Very High Very High Very High
Intellectual Impairment 4 95.16 Very High Very High Very High
Photophobia 1 92.56 High High
Syndrome 1 92.16 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 53 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oral anticoagulant therapy was associated with a marked reduction in mean F1 + 2 (0.63 vs 1.62 nmol/l, p < 0.0001) and TAT levels (1.65 vs 2.23 micrograms/l, p < 0.0001).
Negative_regulation (reduction) of TAT
1) Confidence 0.57 Published 1993 Journal Thromb. Haemost. Section Abstract Doc Link 8115978 Disease Relevance 0.51 Pain Relevance 0.24
In 5 patients with prolonged rest angina who received aspirin, plasma TAT levels (ng/ml) were significantly decreased (4.52 +/- 1.18 at baseline, 2.50 +/- 0.65 at 1 hour and 2.16 +/- 0.42 at 24 hours after aspirin administration, p < 0.01) with a significant decrease in plasma 11-dehydro-TXB2 levels.
Negative_regulation (decreased) of TAT in plasma associated with aspirin and angina
2) Confidence 0.57 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8480641 Disease Relevance 0.64 Pain Relevance 1.23
The plasma level of TAT was also reduced by transdermal nitroglycerin.
Negative_regulation (reduced) of TAT in plasma associated with transdermal
3) Confidence 0.57 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10484053 Disease Relevance 0.22 Pain Relevance 0.20
Intravenous administration of L-arginine increased the serum level of NO derivatives and the platelet count and reduced plasma TAT and FDP levels.
Negative_regulation (reduced) of TAT in plasma
4) Confidence 0.57 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10484053 Disease Relevance 0.27 Pain Relevance 0.19
Oculocutaneous tyrosinemia, Type II, is caused by a deficiency of tyrosine aminotransferase (TAT).
Negative_regulation (deficiency) of TAT associated with tyrosinemia
5) Confidence 0.57 Published 2006 Journal American journal of medical genetics. Part C, Seminars in medical genetics Section Abstract Doc Link 16602095 Disease Relevance 0.98 Pain Relevance 0.08
Deficiency of the hepatic cytosolic enzyme tyrosine aminotransferase (TAT) causes marked hypertyrosinaemia leading to painful palmoplantar hyperkeratoses, pseudodendritic keratitis and variable mental retardation (oculocutaneous tyrosinaemia type II or Richner-Hanhart syndrome).
Negative_regulation (Deficiency) of TAT associated with pain, tyrosinemia, intellectual impairment, syndrome and keratitis
6) Confidence 0.42 Published 2006 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 16917729 Disease Relevance 0.51 Pain Relevance 0.10
TAT level in Group E was more decreased postoperatively than the baseline and those in the other groups (P<0.05).
Negative_regulation (decreased) of TAT
7) Confidence 0.42 Published 2004 Journal Beijing Da Xue Xue Bao Section Body Doc Link 15303131 Disease Relevance 0 Pain Relevance 0
The ceramide precursor palmitoyl-CoA sensitized neurons to Tat and gp120 toxicity, whereas an inhibitor of ceramide production reduced Tat and gp120-induced increases of ceramide and HNE and protected the neurons from Tat and gp120-induced death.
Negative_regulation (reduced) of Tat in neurons associated with toxicity and death
8) Confidence 0.41 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 14755730 Disease Relevance 1.46 Pain Relevance 0.13
Patients with decreased compared with raised F1+2 or TAT levels after 6 hours of treatment had a 50% lower event rate at 30 days (F1+2, P=0.04; TAT, P=0.02).
Negative_regulation (decreased) of TAT
9) Confidence 0.41 Published 2001 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11397720 Disease Relevance 0.48 Pain Relevance 0.08
Plasma levels of PTF1+2, TAT, FPA and D-dimers tended to decrease after the initial dose of PGE1.
Negative_regulation (decrease) of TAT in PGE1
10) Confidence 0.41 Published 2000 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 11090253 Disease Relevance 0.45 Pain Relevance 0.15
A heterologous SHIV-BX08 challenge carried out on seven macaques vaccinated with Tat Oyi/Montanide ISA720 and four control macaques vaccinated with ?
Negative_regulation (vaccinated) of Tat
11) Confidence 0.41 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.40 Pain Relevance 0.03

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