INT56924

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Context Info
Confidence 0.28
First Reported 1993
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.82
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CRTAC1) proteinaceous extracellular matrix (CRTAC1)
Anatomy Link Frequency
blood vessels 1
neuron 1
CRTAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nucleus accumbens 1 95.04 Very High Very High Very High
medulla 5 95.00 High High
Enkephalin 2 94.48 High High
amygdala 1 91.00 High High
Hippocampus 1 89.08 High High
anticonvulsant 1 88.40 High High
headache 2 86.24 High High
substance P 1 81.60 Quite High
Central nervous system 2 79.80 Quite High
antidepressant 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Olfactory Esthesioneuroblastoma 1 98.20 Very High Very High Very High
Skin Cancer 2 97.08 Very High Very High Very High
Cancer 6 96.86 Very High Very High Very High
Anxiety Disorder 1 89.28 High High
Solid Tumor 1 88.72 High High
Nose Bleeds 1 87.56 High High
Nasal Obstruction 1 87.00 High High
Headache 2 86.24 High High
Sleep Disorders 1 86.08 High High
Paresis 1 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was also a proliferation of astrocytes, as determined by immunoreactivity to glial fibrillary acidic protein in the dorsal motor nucleus of the vagus, nucleus tractus solitarius and more generally around blood vessels throughout the brainstem.
acidic protein Spec (determined) Binding (immunoreactivity) of in blood vessels associated with medulla
1) Confidence 0.28 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9057115 Disease Relevance 0.13 Pain Relevance 0.41
Histologically, the tumor was composed of two areas, a main area of large neoplastic cells with pleomorphic atypical nuclei and abundant cytoplasm, which by immunohistochemistry was reactive for glial fibrillary acidic protein, mixed with several foci of poorly differentiated tumoral cells with elongated nuclei and scant cytoplasm, negative for GFAP, but robustly immunoreactive for synaptophysin and phosphoneurofilaments.
acidic protein Binding (reactive) of associated with cancer
2) Confidence 0.09 Published 2006 Journal Acta Neuropathol. Section Abstract Doc Link 16557392 Disease Relevance 1.10 Pain Relevance 0.08
Immunohistochemical positivity for S-100 protein, glial fibrillary acidic protein and vimentin together with negativity for HMB-45 and cytokeratins, as well as mesaxon formation detected with electron microscopy were conclusive in the diagnosis.
acidic protein Binding (positivity) of
3) Confidence 0.01 Published 1993 Journal Virchows Arch A Pathol Anat Histopathol Section Abstract Doc Link 8116230 Disease Relevance 1.42 Pain Relevance 0.09
PRAX-1 mRNA expression was largely neuronal; it colocalized with neuron-specific enolase but not glial fibrillary acidic protein.
acidic protein Binding (colocalized) of in neuron
4) Confidence 0.00 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12435798 Disease Relevance 0.17 Pain Relevance 0.45

General Comments

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