INT56925

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Context Info
Confidence 0.52
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 54
Total Number 56
Disease Relevance 63.39
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
Anatomy Link Frequency
cartilage 1
colon 1
pancreatic duct 1
central nervous system 1
thyroid 1
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 4 99.92 Very High Very High Very High
Central nervous system 5 96.72 Very High Very High Very High
antidepressant 3 96.04 Very High Very High Very High
palliative 16 93.88 High High
metalloproteinase 30 93.20 High High
Chronic pancreatitis 20 92.04 High High
Inflammation 250 90.64 High High
cytokine 127 88.08 High High
tolerance 53 86.60 High High
fibrosis 13 80.56 Quite High
Disease Link Frequency Relevance Heat
Cancer 3069 100.00 Very High Very High Very High
Cholesteatoma 60 100.00 Very High Very High Very High
Watson Syndrome 30 100.00 Very High Very High Very High
Repression 14 100.00 Very High Very High Very High
Chromosome Aberrations 39 99.96 Very High Very High Very High
Malignant Neoplastic Disease 220 99.92 Very High Very High Very High
Colon Cancer 158 99.84 Very High Very High Very High
Subependymal Glioma 31 99.78 Very High Very High Very High
Chondrosarcoma 162 99.68 Very High Very High Very High
Apoptosis 601 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since mitotic recombination is a mechanism leading to malignant growth through the loss of a functional copy of a heterozygous tumor-suppressor gene, fluoxetine may be characterized as an inducer of secondary malignancies in cancer patients after antidepressant treatment.
Negative_regulation (loss) of tumor-suppressor gene associated with malignant neoplastic disease, antidepressant, cancer, metastasis and fluoxetine
1) Confidence 0.52 Published 2009 Journal Drug Chem Toxicol Section Abstract Doc Link 19793026 Disease Relevance 0.65 Pain Relevance 0.44
A higher prevalence of epigenetic inactivation of tumor suppressor genes has been reported in cancer cell line populations compared to primary cancer populations.
Negative_regulation (inactivation) of tumor suppressor associated with cancer
2) Confidence 0.39 Published 2002 Journal Oncogene Section Abstract Doc Link 11960385 Disease Relevance 0.86 Pain Relevance 0
The activation of oncogenes and the inactivation of tumor suppressor genes within neoplastic cells lead to transformation and loss of growth control.
Negative_regulation (inactivation) of tumor suppressor associated with cancer
3) Confidence 0.34 Published 1994 Journal Am Fam Physician Section Abstract Doc Link 8116514 Disease Relevance 0.83 Pain Relevance 0.11
ADV was added to LAM and after reduction in DNA levels, LAM was discontinued and ADV was continued alone.
Negative_regulation (added) of LAM
4) Confidence 0.33 Published 2006 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1459192 Disease Relevance 0.47 Pain Relevance 0
Because SLC5A8 is regarded as a potential tumor suppressor gene that is down-regulated by epigenetic changes in several other cancers, we sought to characterize promoter methylation status and its relationship to SLC5A8 expression in pancreatic cancer.
Negative_regulation (down) of tumor suppressor associated with cancer and pancreatic cancer
5) Confidence 0.15 Published 2008 Journal Pancreas Section Abstract Doc Link 18437076 Disease Relevance 0.54 Pain Relevance 0.07
As reported above, the somatic loss of the wild-type TSC1 and TSC2 allele was found in the chordomas developed by two patients with Tuberous Sclerosis, carrying germline mutations of either TSC gene [13].
Negative_regulation (loss) of TSC1 in germline associated with tuberous sclerosis and chordoma
6) Confidence 0.15 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.25 Pain Relevance 0
The inactivation of this tumor suppressor gene is not necessarily due to radiation exposure itself, but could occur as an early event that increases susceptibility to subsequent ionizing-radiation–induced mutations that result in progression of the carcinogenic process to CLL.


Negative_regulation (inactivation) of tumor suppressor associated with chronic lymphoid leukemia and cancer
7) Confidence 0.08 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253701 Disease Relevance 1.12 Pain Relevance 0
Overexpression of these miRNAs may be due to the loss of p53 tumor suppressor function in tumors.


Negative_regulation (loss) of tumor suppressor associated with cancer
8) Confidence 0.05 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.91 Pain Relevance 0.05
A number of miRNAs were discovered to be deregulated due to the loss of the p53 tumor suppressor in colon cancer cell lines.
Negative_regulation (loss) of tumor suppressor in colon associated with cancer and colon cancer
9) Confidence 0.05 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.72 Pain Relevance 0
The cornerstone of the systemic treatment of advanced colorectal cancer is 5-fluorouracil.However, 5-fluorouracil-induced apoptosis is dependent on p53, a tumor suppressor gene that is lost or inactivated in at least 85% of human colorectal cancers.
Negative_regulation (lost) of tumor suppressor associated with cancer, colon cancer and apoptosis
10) Confidence 0.05 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11912124 Disease Relevance 1.22 Pain Relevance 0
Because monosomy 10 could include loss of tumor suppressor genes, much research has been aimed at identifying possible tumor suppressor genes involved.
Negative_regulation (loss) of tumor suppressor associated with monosomy and cancer
11) Confidence 0.05 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.80 Pain Relevance 0
Deletions and other mutations that result in loss of function of the TP53 tumor suppressor gene are some of the more common abnormalities found in MPNSTs.
Negative_regulation (loss) of tumor suppressor associated with congenital anomalies and cancer
12) Confidence 0.04 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 2.06 Pain Relevance 0
Biallelic inactivation of NF1 and mutations of numerous additional tumor suppressor genes within the p19ARF-MDM2-TP53 and p16INK4A-Rb signaling cascades have been identified in MPNSTs [12,13].
Negative_regulation (inactivation) of tumor suppressor associated with cancer and watson syndrome
13) Confidence 0.04 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 1.94 Pain Relevance 0
The modules that are generated based on these association are found to have a number of common predicted target onco/tumor suppressor genes.
Negative_regulation (number) of tumor suppressor associated with cancer
14) Confidence 0.04 Published 2010 Journal Silenc Section Abstract Doc Link PMC2835996 Disease Relevance 1.01 Pain Relevance 0
Collectively, we speculate that the defect in PAX6 may have contributed to the extremely large size of the subependymoma, due to a loss of tumor suppressor activity in glial cell lineage.



Negative_regulation (loss) of tumor suppressor in glial cell associated with subependymal glioma and cancer
15) Confidence 0.04 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Abstract Doc Link PMC2991767 Disease Relevance 0.97 Pain Relevance 0
Briefly these changes include environment independent growth; insensitivity to antigrowth factors (loss of tumor suppressor genes); evasion of apoptosis (producing survival factors); limitless replicative potential (turning on telomerase); sustained angiogenesis (producing VEGF inducer) and tissue invasion and metastasis (inactivation of E-cadherin).
Negative_regulation (loss) of tumor suppressor associated with cancer, apoptosis and metastasis
16) Confidence 0.04 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.71 Pain Relevance 0
Further, loss of OXPHOS genes SLC25A5, ATP6V1B1, B3, V0A4, and NDUFA4 may contribute to the self-sufficiency of the cancer cells with the ability to be less dependent on OXPHOS (2) The loss of tumor suppressor genes PTPRO, TFAP2A, CDKN1C, AIM1 and MT1G as well as other genes that were shown to suppress tumor growth in cancer cell lines but not yet identified as tumor suppressor candidates (RASD1, VDR, EHF, SPP1, ACPP, MT1F and ERBB4) contributes to insensitivity to antigrowth signals; (3) Evasion of apoptosis is mediated through loss of SPP1 and SFRP1, and activation of TUBB, NOL3 and EGLN3. (4) Two groups of genes are likely to be involved in tissue invasion and metastasis: proteolysis genes (PAPPA, PSMB9 and MARCH-1) and genes involved in cell-adhesion and/or regulation of actin cytoskeleton (CNGLN, ITPR2, NPHS1, ITGB2, CLD1, ZAK, WASF2, CD81) and (5) Angiogenesis may be mediated through ALDOA enzyme which is shown to be activated by HIF1 under hypoxic conditions and by increased glycolytic activity (Warburg effect), and which in a feedback loop activates HIF1 (Lu et al. 2002) which then activates several angiogenic factors including VEGF.
Negative_regulation (loss) of tumor suppressor associated with hypoxia, cancer, apoptosis, adhesions and metastasis
17) Confidence 0.04 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.67 Pain Relevance 0
The historical focus of much of this research has been to identify and study the role of specific genetic abnormalities in tumor cells related to chromosomal abnormalities, inactivation of specific tumor suppressor genes, the activation of specific oncogenes, the expression of hormone receptors and growth factor production associated with the development of cancer.
Negative_regulation (inactivation) of tumor suppressor associated with chromosome aberrations, cancer and congenital anomalies
18) Confidence 0.03 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.10 Pain Relevance 0
p16, a tumor suppressor gene and critical member of the Rb pathway, is inactivated in over 40% of NSCLCs.
Negative_regulation (inactivated) of tumor suppressor associated with cancer
19) Confidence 0.03 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.75 Pain Relevance 0
Imbalance between cell proliferation and apoptosis observed in cancer can be tightly related to an altered function of pro-apoptotic proteins as well as to an up-regulation of anti-apoptotic proteins (i.e., Bcl-2 or IAPs) or a downregulation of tumor suppressor genes (i.e., p53).
Negative_regulation (downregulation) of tumor suppressor associated with cancer and apoptosis
20) Confidence 0.03 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.57 Pain Relevance 0.09

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