INT56957

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0.10
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYOG) nucleus (MYOG) DNA binding (MYOG)
Anatomy Link Frequency
myotubes 3
MYOG (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 25 99.64 Very High Very High Very High
tetrodotoxin 20 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 5 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a working hypothesis we propose that repression of AChR biosynthesis by electrical activity results, at least partly, from phosphorylation of myogenin via the PKC pathway.
Phosphorylation (phosphorylation) of myogenin associated with kinase c and repression
1) Confidence 0.59 Published 1994 Journal Biochemistry Section Abstract Doc Link 8117718 Disease Relevance 0.10 Pain Relevance 0.51
Myogenin dephosphorylation is also observed upon incubation of myotubes with GF109203X, a pharmacological agent which specifically inhibits PKC activity.
Phosphorylation (dephosphorylation) of Myogenin in myotubes associated with kinase c
2) Confidence 0.59 Published 1994 Journal Biochemistry Section Abstract Doc Link 8117718 Disease Relevance 0 Pain Relevance 0.58
The state of phosphorylation of myogenin was followed by 32P-labeling and immunoprecipitation with an anti-myogenin antibody.
Phosphorylation (phosphorylation) of myogenin
3) Confidence 0.59 Published 1994 Journal Biochemistry Section Abstract Doc Link 8117718 Disease Relevance 0 Pain Relevance 0.44
Phosphorylation of myogenin in chick myotubes: regulation by electrical activity and by protein kinase C.
Phosphorylation (Phosphorylation) of myogenin in myotubes associated with kinase c
4) Confidence 0.59 Published 1994 Journal Biochemistry Section Title Doc Link 8117718 Disease Relevance 0 Pain Relevance 0.44
In electrically active myotubes myogenin is phosphorylated, while it is dephosphorylated in electrically silent myotubes following tetrodotoxin (TTX) treatment.
Phosphorylation (phosphorylated) of myogenin in myotubes associated with tetrodotoxin
5) Confidence 0.59 Published 1994 Journal Biochemistry Section Abstract Doc Link 8117718 Disease Relevance 0 Pain Relevance 0.51

General Comments

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