INT57008

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Context Info
Confidence 0.50
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.81
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HPRT1) small molecule metabolic process (HPRT1) transferase activity, transferring glycosyl groups (HPRT1)
cytoplasm (HPRT1)
Anatomy Link Frequency
plasma 1
muscle 1
GCT 1
HPRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 4 99.80 Very High Very High Very High
cytokine 62 84.88 Quite High
Potency 8 78.56 Quite High
Morphine 9 75.48 Quite High
anesthesia 11 68.48 Quite High
imagery 8 66.60 Quite High
Inflammation 15 50.00 Quite Low
Dopamine 25 21.36 Low Low
Neurotransmitter 12 18.52 Low Low
Catecholamine 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 87 98.90 Very High Very High Very High
Infection 3 98.88 Very High Very High Very High
Crystal Associated Disease 27 95.04 Very High Very High Very High
Familial Dysautonomia 196 92.44 High High
Disorder Of Purine Or Pyrimidine Metabolism 3 88.92 High High
Hyperinsulinism 1 88.76 High High
Cytomegalovirus Infection 1 82.56 Quite High
Death 9 76.60 Quite High
Hyperuricemia 39 75.92 Quite High
Congenital Anomalies 12 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nowadays it is considered that between both syndromes, a continuous spectrum of neurological involvement is present in HPRT-deficient patients.
Positive_regulation (present) of HPRT-deficient associated with syndrome
1) Confidence 0.50 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 1.24 Pain Relevance 0
Mean plasma concentrations of urate, hypoxanthine, and xanthine, and their urinary excretion rates, are markedly elevated in HPRT-deficient patients.
Positive_regulation (elevated) of HPRT-deficient in plasma
2) Confidence 0.50 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 0.26 Pain Relevance 0.07
Detection of opiate-enhanced increases in DNA damage, HPRT mutants, and the mutation frequency in human HUT-78 cells.
Positive_regulation (increases) of HPRT associated with opiate
3) Confidence 0.49 Published 1994 Journal Environ. Mol. Mutagen. Section Title Doc Link 8125082 Disease Relevance 0 Pain Relevance 0.52
For normalization of the data the average of the expression level of four house-keeping genes, GAPDH, HPRT, beta-actin and beta-tubulin, was used.



Positive_regulation (used) of HPRT
4) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
Here we show that infection of human 1306, HPRT-negative cells with RAd-HPRT, expressed high enough levels of HPRT enzyme activity, as to reverse their abnormal biochemical phenotype, thus enhancing hypoxanthine incorporation and restoring purine recycling, increasing GTP levels, decreasing adenine incorporation, and allowing cell survival in HAT medium in which only cells expressing high levels of HPRT can survive.
Positive_regulation (levels) of HPRT associated with infection
5) Confidence 0.47 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850548 Disease Relevance 0.49 Pain Relevance 0.07
Lesch-Nyhan patients (grade 4) present undetectable HPRT activity, but in partial HPRT-deficient patients HPRT activity in haemolysate ranges from 0 to 10% [18,19].
Positive_regulation (undetectable) of HPRT
6) Confidence 0.46 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2234399 Disease Relevance 0.07 Pain Relevance 0
The HPRT1 transcript was selected as the reference gene on an empirical basis—HPRT1 expression in these men (1863±111 arbitrary units, mean±SEM) and women (1881±138 arbitrary units) was similar according to the microarray data (this choice does not necessarily mean that HPRT1 expression always is constant in muscle).
Positive_regulation (selected) of HPRT1 in muscle
7) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.09 Pain Relevance 0
For normalization HPRT mRNA was amplified using HPRT-F (5?
Positive_regulation (using) of HPRT
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0 Pain Relevance 0
We have also studied cytotoxicity and mutagenesis induced by the alkylanilines and their major metabolites in AS52 cells, which were derived from HPRT?
Positive_regulation (derived) of HPRT
9) Confidence 0.30 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.08 Pain Relevance 0.04
Since gene expression quantification using RT-qPCR requires a steady reference gene, we selected three genes frequently used for normalization of the data, ABL1, RPLP0, and HPRT1.
Positive_regulation (used) of HPRT1
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.52 Pain Relevance 0
Primer sequences used are as follows: HPRT: 5' CGA GAT GTG ATG AAG GAG ATG G 3' and 5' GGA TTA TAC TGC CTG ACC AAG G 3'; IL-6: 5' ATG AAC TCC TTC TCC ACA AGC GC 3' and 5' GAA GAG CCC TCA GGC TGG ACT G 3'; IL-8: 5' ATG ACT TCC AAG CTG GCC GTG GCT 3' and 5' TCT CAG CCC TCT TCA AAA ACT TCT C 3'; and IL-13: 5' GGA AGC TTC TCC TCA ATC CTC TCC TGT T 3' and 5' GCG GAT TCG TTG AAC CGT CCC TCG CGA AA 3'.
Positive_regulation (follows) of HPRT in GCT
11) Confidence 0.07 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.06 Pain Relevance 0.04

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