INT57018

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Context Info
Confidence 0.08
First Reported 1994
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 3.76
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (GANAB) Golgi apparatus (GANAB) endoplasmic reticulum (GANAB)
carbohydrate metabolic process (GANAB)
Anatomy Link Frequency
myometrium 1
trigeminal ganglia 1
follicle 1
dorsal root ganglia 1
oocytes 1
GANAB (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 21 100.00 Very High Very High Very High
Neuropeptide 3 100.00 Very High Very High Very High
local anesthetic 14 96.64 Very High Very High Very High
Dismenorea 6 90.72 High High
nociceptor 2 90.48 High High
ischemia 2 89.40 High High
tetrodotoxin 3 87.84 High High
Pain 8 86.56 High High
Neuropathic pain 1 53.84 Quite High
antagonist 39 42.00 Quite Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 15 100.00 Very High Very High Very High
Adenoma 30 99.88 Very High Very High Very High
Disease 34 97.88 Very High Very High Very High
Colon Cancer 12 94.08 High High
Cancer 167 93.04 High High
Dysmenorrhea 6 90.72 High High
Disease Progression 1 90.72 High High
Cv Unclassified Under Development 2 89.40 High High
Pain 5 86.56 High High
Nervous System Injury 2 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To extend understanding of this protection we are seeking a possible binding site for the PUFAs on the alpha-subunit of the human cardiac Na+ channel, hH1alpha, transiently expressed in HEK293t cells.
Gene_expression (expressed) of alpha-subunit
1) Confidence 0.08 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11178958 Disease Relevance 0.09 Pain Relevance 0.13
RNA was extracted from all biopsies and quantitative real-time RT-PCR was used to investigate for possible differential expression of the Maxi-K alpha subunit, and that of its splice variants, between these functionally-distinct myometrial tissue sets.


Spec (possible) Gene_expression (expression) of alpha subunit
2) Confidence 0.04 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0.07 Pain Relevance 0.07
Quantitative real-time PCR indicated a decrease in the expression of the Maxi-K alpha subunit with labour onset.
Gene_expression (expression) of alpha subunit
3) Confidence 0.04 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0.05 Pain Relevance 0.05
The objectives of this study were to investigate mRNA expression of the Maxi-K alpha subunit, and that of its splice variants, in human non-pregnant and pregnant myometrium, prior to and after labour onset, to determine whether altered expression of these splice variants is associated with decreased calcium sensitivity observed at labour onset.


Spec (investigate) Gene_expression (expression) of alpha subunit in myometrium
4) Confidence 0.04 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0.09 Pain Relevance 0.09
Co-expression of the human beta 1 subunit with the recombinant human skeletal muscle alpha subunit (hSkM1) in Xenopus oocytes results in Na+ currents that inactivate rapidly.
Gene_expression (expression) of alpha subunit in oocytes
5) Confidence 0.02 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8125980 Disease Relevance 0 Pain Relevance 0.09
Some of these pure somatotrope adenomas also express free alpha-subunit, which is common to the glycoprotein hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH) and chorionic gonadotropin hormone (CG, co-localized in the same cells or even in the same granules as GH) [36].
Gene_expression (express) of alpha-subunit in follicle associated with adenoma
6) Confidence 0.01 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 1.88 Pain Relevance 0
Expression of alternatively spliced sodium channel alpha-subunit genes.
Gene_expression (Expression) of alpha-subunit associated with neuropeptide and sodium channel
7) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15302875 Disease Relevance 0.05 Pain Relevance 0.22
This selectivity has yet to be studied, but may depend on alpha-subunit 1 and 3 normal and malignant tissue expression pattern.
Gene_expression (expression) of alpha-subunit associated with malignant neoplastic disease
8) Confidence 0.01 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.18 Pain Relevance 0
In isolated membranes of cells expressing only the alpha subunit, the neurotoxins had no stimulatory effect on [3H]BTX binding and the potencies of local anesthetic-like channel inhibitors were 10-100-fold lower than those at native sodium channels.
Gene_expression (expressing) of alpha subunit associated with sodium channel and local anesthetic
9) Confidence 0.00 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887969 Disease Relevance 0 Pain Relevance 0.47
Previous studies have shown that sodium channel alpha-subunit NaN is preferentially expressed in small-diameter sensory neurons of dorsal root ganglia and trigeminal ganglia.
Gene_expression (expressed) of alpha-subunit in trigeminal ganglia associated with sodium channel
10) Confidence 0.00 Published 1999 Journal Genomics Section Abstract Doc Link 10444332 Disease Relevance 0.17 Pain Relevance 0.34
Previous studies have shown that sodium channel alpha-subunit NaN is preferentially expressed in small-diameter sensory neurons of dorsal root ganglia and trigeminal ganglia.
Gene_expression (expressed) of alpha-subunit in dorsal root ganglia associated with sodium channel
11) Confidence 0.00 Published 1999 Journal Genomics Section Abstract Doc Link 10444332 Disease Relevance 0.17 Pain Relevance 0.34

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