INT57019

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Context Info
Confidence 0.38
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMB1) nucleoplasm (PSMB1) peptidase activity (PSMB1)
small molecule metabolic process (PSMB1) nucleus (PSMB1) cellular nitrogen compound metabolic process (PSMB1)
Anatomy Link Frequency
oocytes 2
PSMB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 96.68 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that the human beta 1 subunit is widely expressed but does not functionally modify all Na+ channel isoforms.
Gene_expression (expressed) of beta 1 subunit
1) Confidence 0.38 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8125980 Disease Relevance 0 Pain Relevance 0.10
Genomic Southern blot hybridization experiments suggest that a single gene located on chromosome 19 encodes the human beta 1 subunit that is expressed in all three of these tissues.
Gene_expression (expressed) of beta 1 subunit
2) Confidence 0.38 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8125980 Disease Relevance 0 Pain Relevance 0.08
Co-expression of the human beta 1 subunit with the recombinant human skeletal muscle alpha subunit (hSkM1) in Xenopus oocytes results in Na+ currents that inactivate rapidly.
Gene_expression (-) of beta 1 subunit in oocytes
3) Confidence 0.29 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8125980 Disease Relevance 0 Pain Relevance 0.08
Co-expression of the human beta 1 subunit with the recombinant human skeletal muscle alpha subunit (hSkM1) in Xenopus oocytes results in Na+ currents that inactivate rapidly.
Gene_expression (expression) of beta 1 subunit in oocytes
4) Confidence 0.29 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8125980 Disease Relevance 0 Pain Relevance 0.08

General Comments

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