INT57021

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 62
Total Number 65
Disease Relevance 24.77
Pain Relevance 47.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal cord 18
spinal 14
hippocampus 8
glial cell 8
neurons 8
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 468 100.00 Very High Very High Very High
Spinal cord 204 100.00 Very High Very High Very High
Morphine 160 100.00 Very High Very High Very High
antagonist 154 100.00 Very High Very High Very High
Hippocampus 68 100.00 Very High Very High Very High
Dorsal horn 58 100.00 Very High Very High Very High
Inflammation 312 99.98 Very High Very High Very High
Glutamate receptor 63 99.96 Very High Very High Very High
allodynia 69 99.90 Very High Very High Very High
Eae 62 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 32 100.00 Very High Very High Very High
INFLAMMATION 345 99.98 Very High Very High Very High
Stress 107 99.98 Very High Very High Very High
Neuropathic Pain 91 99.90 Very High Very High Very High
Injury 171 99.84 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 51 99.76 Very High Very High Very High
Hypoxia 144 99.48 Very High Very High Very High
Temporomandibular Joint Syndrome 28 99.04 Very High Very High Very High
Colitis 71 99.00 Very High Very High Very High
Hypersensitivity 44 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of NR1 was upregulated in the dorsal horn of spinal cord after chronic morphine treatment.
Positive_regulation (upregulated) of Gene_expression (expression) of NR1 in spinal cord associated with dorsal horn, morphine and spinal cord
1) Confidence 0.70 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.75
In addition, the elevation of NR1 expression by morphine was decreased by the coadministration of nalbuphine in rat cortex.
Positive_regulation (elevation) of Gene_expression (expression) of NR1 in cortex associated with nalbuphine and morphine
2) Confidence 0.70 Published 2006 Journal Arch. Pharm. Res. Section Abstract Doc Link 16964763 Disease Relevance 0.32 Pain Relevance 2.56
Previous work has also reported increased expression of the 2A subunit of the N-methyl-D-aspartate receptor in the dopamine-depleted striatum.
Positive_regulation (increased) of Gene_expression (expression) of N-methyl-D-aspartate receptor in striatum associated with dopamine and nmda receptor
3) Confidence 0.70 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246155 Disease Relevance 0 Pain Relevance 0.55
Unilateral dopamine depletion increases expression of the 2A subunit of the N-methyl-D-aspartate receptor in enkephalin-positive and enkephalin-negative neurons.
Positive_regulation (increases) of Gene_expression (expression) of N-methyl-D-aspartate receptor in neurons associated with dopamine, nmda receptor and enkephalin
4) Confidence 0.70 Published 2001 Journal Neuroscience Section Title Doc Link 11246155 Disease Relevance 0 Pain Relevance 0.73
From this study we conclude that dopamine depletion increases messenger RNA expression of the 2A subunit of the N-methyl-D-aspartate receptor in striatopallidal and presumed striatonigral (enkephalin-negative) neurons.
Positive_regulation (increases) of Gene_expression (expression) of N-methyl-D-aspartate receptor in neurons associated with dopamine, nmda receptor and enkephalin
5) Confidence 0.70 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246155 Disease Relevance 0 Pain Relevance 0.90
RESULTS: Experimental tooth movement led to a statistically significant increase in NMDAR1 expression at protein level from day 1 to 7 after force application initiating tooth movement.
Positive_regulation (increase) of Gene_expression (expression) of NMDAR1 in tooth
6) Confidence 0.69 Published 2009 Journal Angle Orthod Section Body Doc Link 19705939 Disease Relevance 0.07 Pain Relevance 0
The results indicated that the expression of the NMDAR1 in the superficial laminae of the dorsal horn of the spinal cord was increased after DRGn and the time course was compatible with the onset and development of the autotomy induced by DRGn.
Positive_regulation (increased) of Gene_expression (expression) of NMDAR1 in spinal cord associated with ganglionectomy, dorsal horn and spinal cord
7) Confidence 0.69 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10822148 Disease Relevance 0 Pain Relevance 0.76
These results demonstrate significant bilateral increase in NMDAR1 mRNA expression in the ventrolateral areas of the caudal and middle thirds of the PAG and the caudal half of the dorsal raphe following chronic nociception.
Positive_regulation (increase) of Gene_expression (expression) of NMDAR1 mRNA in dorsal associated with nociception, raphe and central grey
8) Confidence 0.69 Published 1998 Journal Ir J Med Sci Section Abstract Doc Link 9780569 Disease Relevance 1.28 Pain Relevance 0.60
These results demonstrate significant bilateral increase in NMDAR1 mRNA expression in the ventrolateral areas of the caudal and middle thirds of the PAG and the caudal one half of the dorsal raphe following chronic nociception.
Positive_regulation (increase) of Gene_expression (expression) of NMDAR1 mRNA in dorsal associated with nociception, raphe and central grey
9) Confidence 0.69 Published 1998 Journal Neurobiology (Bp) Section Abstract Doc Link 9778652 Disease Relevance 1.29 Pain Relevance 0.60
In male Wistar rats, intrathecal morphine infusion (15microg/h) for 5days induced (1) antinociceptive tolerance, (2) downregulation of glutamate transporters (GTs) GLT-1, GLAST, and EAAC1, (3) increasing of NMDA receptor (NMDAR) NR1 subunit expression and phosphorylation, (4) upregulation of protein kinase C gamma (PKCgamma) expression, and (5) glial cell activation.
Positive_regulation (increasing) of Gene_expression (expression) of NR1 in glial cell associated with kinase c, glutamate, nmda receptor, tolerance, antinociceptive, morphine and intrathecal
10) Confidence 0.68 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20478329 Disease Relevance 0 Pain Relevance 1.34
We hypothesized that there may be enteric nervous system sensitization mediated by increased expression of NR1 splice variants following an inflammatory injury to the gut by TNBS colitis.
Positive_regulation (increased) of Gene_expression (expression) of NR1 in gut associated with colitis, inflammation and injury
11) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.54 Pain Relevance 0.24
The RT-PCR probe that recognized all splice variants (NR1 pan) demonstrated a significant increase in NR1 expression (ANOVA F6,14= 6.28, p = 0.0022) following TNBS injection.
Positive_regulation (increase) of Gene_expression (expression) of NR1
12) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.43 Pain Relevance 0.08
Intrathecal coadministration of morphine with an adenylyl cyclase inhibitor (2',5'-dideoxyadenosine) or a protein kinase A inhibitor (H89) also significantly attenuated morphine-induced NR1 and PKCgamma expression, whereas intrathecal treatment with an adenylyl cyclase activator (forskolin) alone mimicked morphine-induced expression of GR, NR1, and PKCgamma.
Positive_regulation (induced) of Gene_expression (expression) of NR1 associated with morphine and intrathecal
13) Confidence 0.61 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.52
The expression of the NMDAR1 increased gradually to reach the peak at day 7 after DRGn (mean right/left IOD ratio=1.52), then decreased thereafter.
Positive_regulation (increased) of Gene_expression (expression) of NMDAR1 associated with ganglionectomy
14) Confidence 0.61 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10822148 Disease Relevance 0 Pain Relevance 0.72
The increased expression of the NMDAR1 at day 7 was suppressed by MK-801 (NMDA receptor antagonist) administered immediately after DRGn, but not by normal saline or 1,2,3,4-tetrahydro-6-nitro-2, 3-dioxo-benzo[f] quinoxaline-7-sulfonamide (NBQX, non-NMDA receptor antagonist).
Positive_regulation (increased) of Gene_expression (expression) of NMDAR1 associated with nmda receptor antagonist and ganglionectomy
15) Confidence 0.61 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10822148 Disease Relevance 0 Pain Relevance 0.76
In this study, the authors examined the effect of subcutaneous injection of siRNA targeting the NR1 subunit of the N-methyl-D-aspartate receptor on silencing NR1 gene expression and subsequently abolishing inflammatory nociception in rats.
Positive_regulation (silencing) of Gene_expression (expression) of NR1 associated with nociception, inflammation and nmda receptor
16) Confidence 0.50 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20463582 Disease Relevance 0.43 Pain Relevance 0.38
These findings suggest that excitotoxic lesions of the spinal cord induce both NR1 expression and NR1 serine phosphorylation.
Positive_regulation (induce) of Gene_expression (expression) of NR1 in spinal cord associated with spinal cord
17) Confidence 0.50 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12946581 Disease Relevance 0.23 Pain Relevance 0.29
These findings demonstrate that the increased expression of NR1 and pNR1 in spinal laminae I-II and V-VI is dependent on activation of CSPAs, which ultimately contribute to the development of thermal hyperalgesia in neuropathic rats.
Positive_regulation (increased) of Gene_expression (expression) of NR1 in spinal associated with thermal hyperalgesia and neuropathic pain
18) Confidence 0.50 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 1.28 Pain Relevance 0.98
These findings demonstrate that the increased expression of NR1 and pNR1 in spinal laminae I-II and V-VI is dependent on activation of CSPAs, which ultimately contribute to the development of thermal hyperalgesia in neuropathic rats.
Positive_regulation (dependent) of Gene_expression (expression) of NR1 in spinal associated with thermal hyperalgesia and neuropathic pain
19) Confidence 0.50 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 1.28 Pain Relevance 0.95
Thus, we next examined whether the depletion of CSPAs with resiniferatoxin (RTX) modified the change of spinal NR1 and pNR1 expression induced by CCI.
Spec (whether) Positive_regulation (induced) of Gene_expression (expression) of NR1 in spinal associated with eae
20) Confidence 0.50 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 0.99 Pain Relevance 0.98

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