INT57023

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 6.92
Pain Relevance 7.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
hippocampus 8
joint 4
dorsal 2
adrenal gland 2
granule cells 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 808 100.00 Very High Very High Very High
antagonist 150 100.00 Very High Very High Very High
Glutamate receptor 92 100.00 Very High Very High Very High
qutenza 7 99.78 Very High Very High Very High
Hippocampus 487 99.68 Very High Very High Very High
amygdala 444 99.68 Very High Very High Very High
substantia gelatinosa 4 99.40 Very High Very High Very High
cerebral cortex 72 98.68 Very High Very High Very High
Inflammation 16 98.64 Very High Very High Very High
intrathecal 1 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.72 Very High Very High Very High
Aging 686 99.44 Very High Very High Very High
Disease 51 99.38 Very High Very High Very High
Targeted Disruption 13 99.32 Very High Very High Very High
Anxiety Disorder 244 98.94 Very High Very High Very High
Arthritis 4 98.88 Very High Very High Very High
Bordatella Infection 1 98.64 Very High Very High Very High
Urological Neuroanatomy 85 98.32 Very High Very High Very High
Shock 68 96.08 Very High Very High Very High
Cognitive Disorder 156 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings provide evidence for a specific decrease in GluR1 expression in the cord in response to joint inflammation.
Negative_regulation (decrease) of Gene_expression (expression) of GluR1 in joint associated with inflammation and arthritis
1) Confidence 0.58 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.31 Pain Relevance 0.37
One day after LPS injection, when joint swelling was maximal, GluR1 expression was bilaterally decreased by 25% in the substantia gelatinosa at the level of the lumbar cord.
Negative_regulation (decreased) of Gene_expression (expression) of GluR1 in joint associated with substantia gelatinosa and pressure and volume under development
2) Confidence 0.58 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.48 Pain Relevance 0.62
In addition, we found that pre- or post-training administration of function-blocking anti-BDNF antibodies into dorsal CA1 hampered IA LTM retention, abolished the learning-induced biphasic activation of mTOR and its readout, p70S6K and blocked GluR1 expression, indicating that BDNF is an upstream factor controlling mTOR signaling during fear-memory consolidation.
Negative_regulation (blocked) of Gene_expression (expression) of GluR1 in dorsal associated with anxiety disorder
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.10 Pain Relevance 0.04
The expression of NR2B (NMDA receptor) and GluR1 (AMPA receptor) subunits was significantly reduced in the TCDD-exposed F1 generation animals compared to vehicle controls.
Negative_regulation (reduced) of Gene_expression (expression) of GluR1 associated with nmda receptor
4) Confidence 0.40 Published 2006 Journal Neurotoxicology Section Abstract Doc Link 16839606 Disease Relevance 0 Pain Relevance 0.21
Here we show that consolidation of inhibitory avoidance (IA) LTM entails mTOR activation in the dorsal hippocampus at the moment of and 3 h after training and is associated with a rapid and rapamycin-sensitive increase in AMPA receptor GluR1 subunit expression, which was also blocked by intra-hippocampal delivery of GluR1 antisense oligonucleotides (ASO).
Negative_regulation (blocked) of Gene_expression (expression) of GluR1 in hippocampus associated with hippocampus
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.05
Also, capsaicin failed to inhibit sIPSCs in the presence of ionotropic glutamate receptor antagonists or in the presence of both LY341495 and CPPG (group II and group III metabotropic glutamate receptor antagonists, respectively).
Negative_regulation (inhibit) of Gene_expression (presence) of glutamate receptor associated with qutenza, antagonist and glutamate receptor
6) Confidence 0.33 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17108089 Disease Relevance 0.53 Pain Relevance 1.40
In contrast, rats given intra-LA infusion of the NO scavenger c-PTIO exhibit a significant decrease in synapsin and synaptophysin expression in the LA, but no significant impairment in the expression of GluR1.
Negative_regulation (impairment) of Gene_expression (expression) of GluR1 associated with amygdala
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2888610 Disease Relevance 0.22 Pain Relevance 0.51
Post hoc analysis using Duncan's t-tests showed that the Paired group exhibited significantly higher expression of GluR1, synapsin, and synaptophysin relative to the Naïve (p<0.001), Tone Alone (p<0.001), or Immediate Shock groups (p<0.001).
Negative_regulation (exhibited) of Gene_expression (expression) of GluR1 associated with shock
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.74 Pain Relevance 0.17
Relative to naïve controls, fear conditioned rats exhibited significant increases in levels of GluR1 expression in the LA at 24 hours [t(15)?
Negative_regulation (levels) of Gene_expression (expression) of GluR1 associated with anxiety disorder and amygdala
9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.78 Pain Relevance 0.18
Previously, in cultured retinal neural cells, we found that the protein levels of GluR1 and GluR6/7 subunits decrease and GluR2 and KA2 subunits increase [29].
Negative_regulation (decrease) of Gene_expression (levels) of GluR1 in neural
10) Confidence 0.29 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.55 Pain Relevance 0.35
RESULTS: Single dose of morphine was followed by a decrease in gene expression of glutamate receptor subunit NMDAR1 in the adrenal gland.
Negative_regulation (decrease) of Gene_expression (expression) of glutamate receptor in adrenal gland
11) Confidence 0.27 Published 2001 Journal Endocr Regul Section Body Doc Link 11858765 Disease Relevance 0 Pain Relevance 0
Decrease in glutamate receptor gene expression in adrenals induced by a single dose of morphine may result in a modulation of adrenal function in response to subsequent exposure to opioids and contribute to some alterations occurring during opioid drug abuse.


Negative_regulation (Decrease) of Gene_expression (expression) of glutamate receptor
12) Confidence 0.27 Published 2001 Journal Endocr Regul Section Body Doc Link 11858765 Disease Relevance 0 Pain Relevance 0
In contrast, the gene-transcript expression of GluR1 was reduced in the hippocampus.
Negative_regulation (reduced) of Gene_expression (expression) of GluR1 in hippocampus associated with hippocampus
13) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.12 Pain Relevance 0.34
The increase in Glur1 staining intensity and concomitant decrease in GluR2/3 staining intensity found here in deprived cortex 1?
Negative_regulation (decrease) of Gene_expression (intensity) of Glur1 in cortex
14) Confidence 0.18 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.06 Pain Relevance 0.16
Additionally, the mitogen activated protein (MAP) kinase inhibitor PD98059 enhances BDNF-induced glutamate receptor-1 (GluR1) protein expression, but a phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 strongly reduces BDNF-induced GluR1 protein expression.
Negative_regulation (reduces) of Gene_expression (expression) of GluR1 associated with glutamate receptor
15) Confidence 0.07 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12069900 Disease Relevance 0 Pain Relevance 0.26
In the presence of glutamate receptor antagonists (CNQX 17.2 ?
Negative_regulation (presence) of Gene_expression (antagonists) of glutamate receptor associated with antagonist and glutamate receptor
16) Confidence 0.05 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543467 Disease Relevance 0.44 Pain Relevance 0.68
A decrease in the protein expression of the GluN1 subunit protein is also observed in the distal dendrites of the dentate granule cells in aged macaque monkeys, as compared to young adults (Gazzaley et al., 1996a).
Negative_regulation (decrease) of Gene_expression (expression) of GluN1 in granule cells
17) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.26 Pain Relevance 0.25
However, Fischer 344 rats did show a greater age-related decline in protein expression of the NMDA receptor subunits GluN1 and GluN2B than the AMPA receptor subunits GluA1, GluA2, or GluA2/3 in the hippocampus (Clayton and Browning, 2001; Clayton et al., 2002b; Coultrap et al., 2008).
Negative_regulation (decline) of Gene_expression (expression) of GluN1 in hippocampus associated with nmda receptor and hippocampus
18) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.36 Pain Relevance 0.51
A study by Calon et al. (2005) showed that in a mouse model of AD with n-3 PUFA deficiency, the expression levels of GluN1, GluN2A and GluN2B subunits are significantly decreased compared to non-transgenic mice.
Negative_regulation (decreased) of Gene_expression (expression) of GluN1 associated with targeted disruption and disease
19) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.63 Pain Relevance 0.07
These declines in the expression of the GluN1 subunit are less than those seen for the GluN2B subunit (Magnusson, 2000; Magnusson et al., 2002) and are not always consistent between studies involving aged C57BL/6 mice (Ontl et al., 2004; Magnusson et al., 2005; Das and Magnusson, 2008; Zhao et al., 2009b).
Negative_regulation (declines) of Gene_expression (expression) of GluN1
20) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.47 Pain Relevance 0.43

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