INT57024

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 8
Speculated 14
Reported most in Abstract
Documents 32
Total Number 46
Disease Relevance 9.77
Pain Relevance 32.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal cord 18
hippocampal formation 6
brain 6
spinal 6
CeA 5
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 407 100.00 Very High Very High Very High
Spinal cord 198 100.00 Very High Very High Very High
Inflammation 168 100.00 Very High Very High Very High
Morphine 124 100.00 Very High Very High Very High
antagonist 104 100.00 Very High Very High Very High
substance P 101 100.00 Very High Very High Very High
cocaine 37 100.00 Very High Very High Very High
Glutamate 37 100.00 Very High Very High Very High
Serotonin 34 100.00 Very High Very High Very High
Glutamate receptor 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 94 100.00 Very High Very High Very High
Nociception 144 99.68 Very High Very High Very High
INFLAMMATION 165 99.52 Very High Very High Very High
Nervous System Injury 4 99.52 Very High Very High Very High
Colitis 46 99.32 Very High Very High Very High
Drug Dependence 8 99.32 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 16 99.12 Very High Very High Very High
Temporomandibular Joint Syndrome 9 98.72 Very High Very High Very High
Frailty 16 98.36 Very High Very High Very High
Neuropathic Pain 74 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to examine the influence of Group I mGluRs antagonists on the expression of NMDA receptor NR1 subunit (NR1) in the rat spinal cord.
Spec (examine) Regulation (influence) of Gene_expression (expression) of NR1 subunit in spinal cord associated with nmda receptor, antagonist and spinal cord
1) Confidence 0.62 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.27
The effect of drugs of abuse on NMDAR1 receptor expression in the rat limbic system.
Regulation (effect) of Gene_expression (expression) of NMDAR1 associated with limbic system
2) Confidence 0.62 Published 2003 Journal Drug Alcohol Depend Section Title Doc Link 14636974 Disease Relevance 0.09 Pain Relevance 1.03
The purpose of this study therefore was to determine whether dopamine depletion differentially alters the expression of the 2A subunit of the N-methyl-D-aspartate receptor in rat striatal neurons. 6-Hydroxydopamine (8microg/2microl) was infused unilaterally into the medial forebrain bundle.
Spec (whether) Regulation (alters) of Gene_expression (expression) of N-methyl-D-aspartate receptor in medial forebrain bundle associated with dopamine and nmda receptor
3) Confidence 0.62 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246155 Disease Relevance 0 Pain Relevance 0.57
Changes in the time taken by the rats on nocifensive behavior then effects of NMDA receptor antagonist MK-801 and force magnitude on these changes in behavior and NMDAR1 expression were evaluated.
Regulation (changes) of Gene_expression (expression) of NMDAR1
4) Confidence 0.62 Published 2009 Journal Angle Orthod Section Body Doc Link 19705939 Disease Relevance 0.08 Pain Relevance 0
Because of the importance of NR1 in central sensitization, the first goal of this study was to examine both time- and lamina-dependent changes in spinal NR1 and pNR1 expression in a chronic constriction injury (CCI) model of neuropathic pain.
Spec (examine) Regulation (changes) of Gene_expression (expression) of NR1 in spinal associated with central sensitization, eae, injury and neuropathic pain
5) Confidence 0.61 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 0.58 Pain Relevance 0.73
Thus, the effects of gonadal steroids on NMDA receptor-mediated responses are not due to regulation of NR1 expression.
Regulation (regulation) of Gene_expression (expression) of NR1 in gonadal associated with nmda receptor
6) Confidence 0.60 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12464400 Disease Relevance 0 Pain Relevance 0.32
In contrast to the NR1 serine phosphorylation it was notable that these short duration stimuli did not induce any detectable change in NR1 protein expression.
Regulation (change) of Gene_expression (expression) of NR1 protein
7) Confidence 0.57 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.64 Pain Relevance 0.65
These results suggest that changes in the expression of the NR1 mRNA induced by chronic morphine in three CNS regions involved in antinociception are associated with the development of morphine tolerance and in the spinal cord, morphine tolerance is associated with the downregulation of NMDA receptors.
Regulation (changes) of Gene_expression (expression) of NR1 mRNA in spinal cord associated with antinociception, nmda receptor, tolerance, spinal cord and morphine
8) Confidence 0.56 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12829326 Disease Relevance 0.08 Pain Relevance 1.80
Under these conditions, mRNA and protein levels of NR1, NR2A and NR2B subunits did not change in the spinal cord of chronic ethanol-fed rats.
Neg (not) Regulation (change) of Gene_expression (levels) of NR1 in spinal cord associated with spinal cord
9) Confidence 0.54 Published 2007 Journal Life Sci. Section Abstract Doc Link 17156796 Disease Relevance 0.49 Pain Relevance 0.79
In summary, the present data demonstrate adaptive changes in the NR subunit expression pattern in rat spinal cord due to formalin injection.
Regulation (changes) of Gene_expression (expression) of NR subunit in spinal cord associated with nmda receptor and spinal cord
10) Confidence 0.46 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373534 Disease Relevance 0.08 Pain Relevance 0.40
Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats.
Regulation (effects) of Gene_expression (expression) of NR1 subunit associated with nmda receptor, antagonist, glutamate receptor and morphine
11) Confidence 0.45 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.54
The aim of the present study was to examine the influence of Group I mGluRs antagonists on the expression of NMDA receptor NR1 subunit (NR1) in the rat spinal cord.
Spec (examine) Regulation (influence) of Gene_expression (expression) of NR1 in spinal cord associated with nmda receptor, antagonist and spinal cord
12) Confidence 0.45 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.27
We studied the influence of acute and repeated morphine (20 mg/kg i.p. or increasing dose for 10 days) and cocaine (3x20 mg/kg i.p. per day at hourly intervals, for 1 or 5 days) administration on the expression of glutamate NMDA receptor subunit 1 (NMDAR1) in the central and basolateral nuclei of the rat amygdala and hippocampal formation.
Regulation (influence) of Gene_expression (expression) of NMDAR1 in hippocampal formation associated with glutamate, nmda receptor, amygdala, cocaine and morphine
13) Confidence 0.45 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 14636974 Disease Relevance 0.10 Pain Relevance 0.91
We studied the influence of acute and repeated morphine (20 mg/kg i.p. or increasing dose for 10 days) and cocaine (3x20 mg/kg i.p. per day at hourly intervals, for 1 or 5 days) administration on the expression of glutamate NMDA receptor subunit 1 (NMDAR1) in the central and basolateral nuclei of the rat amygdala and hippocampal formation.
Regulation (influence) of Gene_expression (expression) of glutamate NMDA receptor subunit 1 in hippocampal formation associated with glutamate, nmda receptor, amygdala, cocaine and morphine
14) Confidence 0.45 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 14636974 Disease Relevance 0.10 Pain Relevance 0.90
Thus, we next examined whether the depletion of CSPAs with resiniferatoxin (RTX) modified the change of spinal NR1 and pNR1 expression induced by CCI.
Spec (whether) Regulation (change) of Gene_expression (expression) of NR1 in spinal associated with eae
15) Confidence 0.45 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 0.98 Pain Relevance 0.98
RESULTS: Long-term morphine infusion induced antinociceptive tolerance and up-regulated N-methyl-d-aspartate receptor subunits NR1 and NR2B expression in both total lysate and synaptosome fraction of the spinal cord dorsal horn.
Regulation (regulated) of Gene_expression (expression) of NR1 in spinal cord dorsal horn
16) Confidence 0.43 Published 2010 Journal Anesthesiology Section Body Doc Link 20938337 Disease Relevance 0 Pain Relevance 0
The TNP-ATP regulation on the N-methyl-d-aspartate receptor expression may be involved in a loss of scaffolding proteins postsynaptic density-95.


Regulation (regulation) of Gene_expression (expression) of N-methyl-d-aspartate receptor
17) Confidence 0.43 Published 2010 Journal Anesthesiology Section Body Doc Link 20938337 Disease Relevance 0 Pain Relevance 0
In this study we examined the effects of chronic morphine administration on gene and protein expression of three major NMDA receptors subunits (NR1, NR2A, and NR2B) in NAcc and CeA.
Spec (examined) Regulation (effects) of Gene_expression (expression) of NR1 in CeA associated with nucleus accumbens, nmda receptor, amygdala and morphine
18) Confidence 0.42 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16453311 Disease Relevance 0.09 Pain Relevance 1.50
Here we show that the expression of spinal NMDAR and PKCgamma after chronic morphine is regulated by spinal GR through a cAMP response element-binding protein (CREB)-dependent pathway.
Regulation (regulated) of Gene_expression (expression) of NMDAR in spinal associated with morphine
19) Confidence 0.40 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.00
In contrast, no significant change was apparent in GluR2, GluR3, or NR1 expression in any nucleus of the cord.
Regulation (apparent) of Gene_expression (expression) of NR1 in nucleus
20) Confidence 0.39 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.35 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox