INT57025

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Context Info
Confidence 0.32
First Reported 1994
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gria3) protein complex (Gria3)
Anatomy Link Frequency
laminas 1
nucleus 1
Gria3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 2 97.08 Very High Very High Very High
Dorsal horn 4 91.40 High High
Spinal cord 8 90.92 High High
Glutamate 5 81.84 Quite High
unmyelinated 1 78.80 Quite High
Inflammation 2 76.80 Quite High
Glutamate receptor 4 75.00 Quite High
ischemia 2 75.00 Quite High
amygdala 1 74.64 Quite High
nMDA receptor 1 69.56 Quite High
Disease Link Frequency Relevance Heat
Infarction 2 97.10 Very High Very High Very High
Pressure And Volume Under Development 1 93.40 High High
Middle Cerebral Artery Infarction 2 76.64 Quite High
Arthritis 2 75.00 Quite High
Brain Hemorrhage 1 75.00 Quite High
Death 3 72.40 Quite High
INFLAMMATION 1 67.24 Quite High
Cv Unclassified Under Development 1 63.56 Quite High
Pain 1 59.32 Quite High
Nociception 1 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, no significant change was apparent in GluR2, GluR3, or NR1 expression in any nucleus of the cord.
Regulation (apparent) of GluR3 in nucleus
1) Confidence 0.32 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.35 Pain Relevance 0.54
Colocalization studies showed that GluR2 was present at virtually all (98%) puncta that were GluR1, GluR3, or GluR4 immunoreactive and that most (>90%) immunoreactive puncta in laminas IV, V, and IX showed GluR2, GluR3, and GluR4 immunoreactivity.
Regulation (immunoreactivity) of GluR3 in laminas
2) Confidence 0.17 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.34
In cortical regions destined to undergo infarction, GluR2 and NR1 messenger RNAs were preferentially reduced relative to the contralateral side (to 75+/-8.5% and 66+/-4.5%, respectively); GluR1, GluR3 and preproenkephalin messenger RNAs were unaltered.
Regulation (unaltered) of GluR3 associated with infarction
3) Confidence 0.09 Published 2000 Journal Neuroscience Section Abstract Doc Link 10670452 Disease Relevance 0.56 Pain Relevance 0.28

General Comments

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