INT57039

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 1.98
Pain Relevance 9.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 4
substantia nigra 2
NAc 2
neurons 2
hippocampus region 2
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 715 100.00 Very High Very High Very High
dopamine receptor 67 100.00 Very High Very High Very High
agonist 66 100.00 Very High Very High Very High
antagonist 64 100.00 Very High Very High Very High
Enkephalin 39 100.00 Very High Very High Very High
midbrain 38 99.68 Very High Very High Very High
fluoxetine 2 99.52 Very High Very High Very High
Morphine 28 99.48 Very High Very High Very High
Substantia nigra 32 99.36 Very High Very High Very High
Serotonin 36 98.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 12 99.76 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 11 99.44 Very High Very High Very High
Brain Disease 5 94.80 High High
Diphtheria 1 90.12 High High
Attention Deficit Hyperactivity Disorder 195 89.52 High High
Targeted Disruption 80 88.48 High High
Sprains And Strains 25 79.84 Quite High
Stress 8 74.44 Quite High
Anxiety Disorder 6 46.96 Quite Low
Ataxia 1 42.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the loss of DA innervation caused by 6-hydroxydopamine (6-OHDA) increased the expression of mRNAs encoding the D2R and enkephalin selectively in striatopallidal MSNs, whereas mRNAs encoding the D1R and substance P were only decreased in striatonigral MSNs (Gerfen et al., 1990).
Positive_regulation (increased) of Gene_expression (expression) of D2R associated with dopamine, enkephalin and substance p
1) Confidence 0.50 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.58
The lack of ERK activation in neurons expressing D2R may result from a negative effect of D2R on ERK activation, since pharmacological blockade of D2Rs by haloperidol or raclopride selectively activates ERK and induces histone H3 phosphorylation in D2R-expressing striatopallidal MSNs in the dorsal striatum (Bertran-Gonzalez et al., 2008, 2009).
Positive_regulation (activation) of Gene_expression (expressing) of D2R in striatum
2) Confidence 0.50 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.13 Pain Relevance 0.33
Such measurement requires the expression of markers for D1R and D2R in the same animal.
Positive_regulation (requires) of Gene_expression (expression) of D2R
3) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.16 Pain Relevance 0.13
While abnormal serotonin signaling is not sufficient to generate the depressive behaviors, increasing D2r expression by chronic fluoxetine (Prozac) treatment or adenoassociated virus type2 (AAV2) mediated expression of Rxrgamma or D2r in the NAc of Rxrgamma(-/-) mice normalizes depressive-like behaviors in Rxrgamma(-/-) animals.
Positive_regulation (increasing) of Gene_expression (expression) of D2r in NAc associated with nucleus accumbens, depression, serotonin and fluoxetine
4) Confidence 0.49 Published 2010 Journal Neuron Section Abstract Doc Link 20620876 Disease Relevance 0.36 Pain Relevance 0.54
These new mouse lines, in which the enhanced green fluorescent protein (EGFP) is driven by D1R or D2R promoters, provide an easy way to label neurons which express high levels of D1R or D2R (reviewed in Valjent et al., 2009).
Positive_regulation (levels) of Gene_expression (express) of D2R in neurons
5) Confidence 0.47 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.17 Pain Relevance 0.03
- tgg tca atc tca gtc act ttt ca- 3?)
Positive_regulation (-) of Gene_expression (tca) of DRD2
6) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.06
Bronikowski and colleagues (2004) investigated gene expression changes in the
    hippocampus region of the brain and found that mice selectively bred for high wheel running had
    a 20% increase in D2 and D4 receptor expression (D1-like receptors were not analyzed in this
    study) compared to control line mice 16. 
Positive_regulation (increase) of Gene_expression (expression) of D2 in hippocampus region associated with hippocampus
7) Confidence 0.40 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.15 Pain Relevance 0.19
In addition to the expression of high levels of the rat dopamine D2-receptor, these mouse cells also express sigma binding sites.
Positive_regulation (levels) of Gene_expression (expression) of D2-receptor associated with dopamine
8) Confidence 0.40 Published 1993 Journal Cell. Signal. Section Abstract Doc Link 8130078 Disease Relevance 0 Pain Relevance 0.35
The D2 receptor mRNA expression was also increased by repeated morphine administration.
Positive_regulation (increased) of Gene_expression (expression) of D2 receptor mRNA associated with morphine
9) Confidence 0.38 Published 2006 Journal Pharmacology Section Abstract Doc Link 17063042 Disease Relevance 0 Pain Relevance 1.59
It may be concluded that morphine-induced sensitization may be due to increase in D2 receptor mRNA expression.
Positive_regulation (increase) of Gene_expression (expression) of D2 receptor mRNA associated with morphine
10) Confidence 0.38 Published 2006 Journal Pharmacology Section Abstract Doc Link 17063042 Disease Relevance 0 Pain Relevance 1.52
Pharmacological studies show that Fos immunoreactivity in the striatum and other key regions of
   the brain is increased following administration of D1 and D2 agonists 58, 66, 69, 109, 126, suggesting Fos may be important as a downstream gene regulated by dopaminergic
   signaling. ?
Positive_regulation (administration) of Gene_expression (agonists) of D2 in striatum associated with agonist
11) Confidence 0.38 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0 Pain Relevance 0.25
DRD2 expression is increased in the VTA and substantia nigra, suggesting increased inhibition of dopamine neuron firing rate [157].
Positive_regulation (increased) of Gene_expression (expression) of DRD2 in substantia nigra associated with dopamine, substantia nigra and midbrain
12) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.91 Pain Relevance 0.49
This cell line is transfected with a eucaryotic expression vector containing the gene of the rat dopamine D2B-receptor (short isoform of the D2-receptor) (Bunzow et al., Nature, 1988).
Positive_regulation (transfected) of Gene_expression (transfected) of D2-receptor associated with dopamine
13) Confidence 0.29 Published 1993 Journal Cell. Signal. Section Abstract Doc Link 8130078 Disease Relevance 0 Pain Relevance 0.33
Quantitative in situ hybridization analysis showed an increase in D2 dopamine receptor and enkephalin messenger RNA expression.
Positive_regulation (increase) of Gene_expression (expression) of D2 dopamine receptor associated with dopamine receptor and enkephalin
14) Confidence 0.26 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682709 Disease Relevance 0.09 Pain Relevance 0.60
Mitochondrial transport is reversibly modulated by sequential activation of D2R and D1R receptors
Positive_regulation (activation) of Gene_expression (receptors) of D2R
15) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0 Pain Relevance 0.19
These cells were also negative for various striatal markers such as Ebf1 or enkephalin mRNAs and calbindin, DARPP32 and dopamine 2 receptor, suggesting that they are unable to differentiate (Colombo et al., 2007).
Positive_regulation (negative) of Gene_expression (mRNAs) of dopamine 2 receptor associated with dopamine and enkephalin
16) Confidence 0.06 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0 Pain Relevance 0.18
Moreover, the present findings suggest that increased enkephalin expression after repeated D2 receptor antagonist treatment is an adaptive response that counteracts functional consequences of D2 receptor blockade, but is not involved in suppressed immediate-early gene induction.
Positive_regulation (increased) of Gene_expression (expression) of D2 receptor associated with antagonist and enkephalin
17) Confidence 0.03 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.06
Moreover, the present findings suggest that increased enkephalin expression after repeated D2 receptor antagonist treatment is an adaptive response that counteracts functional consequences of D2 receptor blockade, but is not involved in suppressed immediate-early gene induction.
Neg (not) Positive_regulation (involved) of Gene_expression (expression) of D2 receptor associated with antagonist and enkephalin
18) Confidence 0.03 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.07

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