INT5704

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Context Info
Confidence 0.43
First Reported 1980
Last Reported 2011
Negated 0
Speculated 7
Reported most in Abstract
Documents 78
Total Number 85
Disease Relevance 8.52
Pain Relevance 51.78

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transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
brain 13
spinal cord 3
dentate gyrus 2
neural 2
lateral 2
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 396 100.00 Very High Very High Very High
agonist 302 100.00 Very High Very High Very High
Enkephalin 271 100.00 Very High Very High Very High
antagonist 173 100.00 Very High Very High Very High
opioid receptor 83 100.00 Very High Very High Very High
Opioid 77 100.00 Very High Very High Very High
Morphine 47 100.00 Very High Very High Very High
opiate 45 100.00 Very High Very High Very High
narcan 32 100.00 Very High Very High Very High
Analgesic 16 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tics 21 100.00 Very High Very High Very High
Alcohol Addiction 10 100.00 Very High Very High Very High
Diabetes Mellitus 91 99.82 Very High Very High Very High
Depression 127 99.70 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 311 94.96 High High
Cv General 3 Under Development 1 92.72 High High
Syndrome 44 92.04 High High
Schizophrenia 101 91.44 High High
Asthma 1 91.32 High High
Stress 29 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This bias increased with the duration of pairing, regardless of which surround whisker (D1 or D3) was paired with D2.
D2 Binding (paired) of in whisker
1) Confidence 0.43 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7965093 Disease Relevance 0.16 Pain Relevance 0.07
Chronic administration of haloperidol leads to an increase in striatal D2 receptor binding; however, studies examining striatal D2 receptor mRNA after haloperidol treatment report inconsistent results.
D2 Binding (binding) of
2) Confidence 0.34 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.26
Opiate binding sites of the kappa-subtype were visualized in guinea-pig brain sections using in vitro autoradiography. kappa-Binding sites, defined as [3H](-)-bremazocine binding in the presence of high concentrations of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin, were found in the cortical laminae V and VI, hippocampal dentate gyrus, and lateral habenulae.
D-Ala2 Binding (binding) of in dentate gyrus associated with enkephalin and opiate
3) Confidence 0.32 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6295776 Disease Relevance 0 Pain Relevance 0.37
Opiate binding sites of the kappa-subtype were visualized in guinea-pig brain sections using in vitro autoradiography. kappa-Binding sites, defined as [3H](-)-bremazocine binding in the presence of high concentrations of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin, were found in the cortical laminae V and VI, hippocampal dentate gyrus, and lateral habenulae.
D-Ala2 Binding (binding) of in dentate gyrus associated with enkephalin and opiate
4) Confidence 0.32 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6295776 Disease Relevance 0 Pain Relevance 0.37
In vitro binding studies in rat brains showed that terguride, similar to lisuride, had a high affinity for D2-, 5-HT1A-, 5-HT2-, alpha 1- and alpha 2-receptors.
D2 Binding (affinity) of in brains
5) Confidence 0.31 Published 1993 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 8370555 Disease Relevance 0.07 Pain Relevance 0.20
In vitro, amisulpride selectively binds to D2 and D3 dopamine receptors, but with preference for the latter.
D2 Binding (binds) of associated with dopamine receptor
6) Confidence 0.27 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695215 Disease Relevance 0.22 Pain Relevance 0.11
However there are other reports to the effect that amisulpride and risperidone demonstrate very similar D2/D3 binding in limbic and striatal areas, in both patients and healthy volunteers.8 More work9 confirmed that amisulpride does bind to D2 receptors and this is dose dependent.
D2 Binding (bind) of
7) Confidence 0.27 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695215 Disease Relevance 0.53 Pain Relevance 0.07
Thus, increased striatal D2 binding after haloperidol treatment may not be the result of altered D2 gene activity in the striatum or midbrain, but could result from an increase in D2 mRNA in cingulate corticostriatal neurons and/or a longer half-life for the D2 receptor protein in striatal neurons.
D2 Binding (binding) of in neurons associated with midbrain
8) Confidence 0.25 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.38
These results suggest that ACTH-(1-24) enhances the stimulus-evoked release of dopamine in the septum via a mechanism not associated with dopamine D2 autoreceptors.
D2 Binding (associated) of associated with dopamine
9) Confidence 0.22 Published 1989 Journal Brain Res. Section Abstract Doc Link 2550107 Disease Relevance 0 Pain Relevance 0.79
Double reciprocal analysis suggested a mixed competitive-noncompetitive type of inhibition of [D-Ala2,D-Leu5]-enkephalin binding by dihydromorphine.
D-Ala2 Binding (binding) of associated with enkephalin
10) Confidence 0.22 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6287305 Disease Relevance 0 Pain Relevance 1.22
Our results, together with other previous studies on the location of D2 receptors on dopamine neurons, suggest that peripheral administration of low doses of apomorphine inhibits nigral dopamine neurons by acting at D2 receptors located on the dendrites of these neurons.
D2 Binding (acting) of in dopamine neurons associated with dopamine
11) Confidence 0.21 Published 1992 Journal Neuroscience Section Abstract Doc Link 1359456 Disease Relevance 0 Pain Relevance 0.56
Interaction between D2 dopaminergic and glutamatergic excitatory influences on lower urinary tract function in normal and cerebral-infarcted rats.
D2 Binding (Interaction) of in lower urinary tract associated with anesthesia
12) Confidence 0.19 Published 2001 Journal Exp. Neurol. Section Title Doc Link 11312567 Disease Relevance 0.51 Pain Relevance 0.43
Neither the specific binding of [3H][D-Pen2,D-Pen5]enkephalin nor [3H]Tyr-D-Ala-Gly-NMePhe-Gly-ol to membranes of frontal or parietal cortices, striatum or hippocampus, prepared from rats chronically treated with AlCl3, were affected.
D-Pen2 Binding (binding) of in parietal associated with hippocampus and enkephalin
13) Confidence 0.18 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477890 Disease Relevance 0.07 Pain Relevance 0.92
However there are other reports to the effect that amisulpride and risperidone demonstrate very similar D2/D3 binding in limbic and striatal areas, in both patients and healthy volunteers.8 More work9 confirmed that amisulpride does bind to D2 receptors and this is dose dependent.
D2 Binding (binding) of
14) Confidence 0.17 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695215 Disease Relevance 0.48 Pain Relevance 0.06
It is shown that the effect of both di- and trivalent metal cations on the [3H-Tyr1, D-Ala2, D-Leu3] enkephalin binding is mediated through one cation attachment site on the respective enkephalin receptor.
D-Ala2 Binding (binding) of associated with enkephalin
15) Confidence 0.17 Published 1984 Journal Bioorg. Khim. Section Abstract Doc Link 6093821 Disease Relevance 0 Pain Relevance 0.64
Kinetic analysis revealed that Ca2+ decreased the rate of dissociation of [D-Ala2,D-Leu5]-enkephalin without affecting the rate of association, thereby increasing the affinity.
D-Ala2 Binding (dissociation) of associated with enkephalin
16) Confidence 0.17 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6287305 Disease Relevance 0 Pain Relevance 1.31
This action was enhanced by the allosteric GabaA receptor modulators, diazepam and secobarbital, and inhibited by the GabaA antagonist, bicuculline, by ligands for D2 or muscarinic cholinergic receptors or by low calcium buffer, tetrodotoxin or vesamicol.
D2 Binding (ligands) of associated with tetrodotoxin and antagonist
17) Confidence 0.15 Published 1998 Journal Brain Res. Section Abstract Doc Link 9473575 Disease Relevance 0 Pain Relevance 0.23
Eighty percent of [3H]-[D-Ala2,D-Leu5] enkephalin (DADLE) binding was displaced by DAGO with high affinity, indicating that a high percentage of [3H]-DADLE binding was at mu-sites.
D-Ala2 Binding (binding) of associated with enkephalin
18) Confidence 0.15 Published 1992 Journal J. Recept. Res. Section Abstract Doc Link 1314311 Disease Relevance 0 Pain Relevance 0.85
Binding of dermorphin to the two major opioid receptor types, mu and delta, in rat brain membranes was examined by displacement of [3H] [D-Ala2, MePhe4, Gly-(ol)5]enkephalin (DAGO) and [3H]-[D-Ala2,D-Leu5]-enkephalin (DADLE) binding.
D-Ala2 Binding (binding) of in brain associated with enkephalin and opioid receptor
19) Confidence 0.15 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3033543 Disease Relevance 0 Pain Relevance 0.47
The experimental results suggest that morphine and D-Ala2, D-Leu5-enkephalin binding both to the high affinity and low affinity sites has different nature and point to the utility of stable and standard preparations of lyophilized membranes for the use in the receptor analysis of opiate and opioid peptides.
D-Ala2 Binding (binding) of associated with opiate, enkephalin, opioid and morphine
20) Confidence 0.14 Published 1984 Journal Biokhimiia Section Abstract Doc Link 6089917 Disease Relevance 0 Pain Relevance 0.85

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