INT57057

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 131
Total Number 136
Disease Relevance 122.24
Pain Relevance 8.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
liver 11
colon 6
plasma 5
monocyte 5
germline 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 193 99.60 Very High Very High Very High
Inflammation 836 99.40 Very High Very High Very High
cytokine 254 99.36 Very High Very High Very High
chemokine 104 98.24 Very High Very High Very High
Inflammatory response 96 97.84 Very High Very High Very High
rheumatoid arthritis 187 97.60 Very High Very High Very High
Etanercept 5 97.36 Very High Very High Very High
lidocaine 9 97.20 Very High Very High Very High
Spinal cord 168 96.84 Very High Very High Very High
Bile 70 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 3421 100.00 Very High Very High Very High
Cancer 2286 100.00 Very High Very High Very High
Pneumonia 201 100.00 Very High Very High Very High
Neuroblastoma 2 100.00 Very High Very High Very High
Pancreatitis 1146 99.96 Very High Very High Very High
Hepatocellular Cancer 1557 99.92 Very High Very High Very High
Multiple Organ Failure 632 99.84 Very High Very High Very High
Pancreatic Cancer 40 99.84 Very High Very High Very High
Liver Cancer 316 99.52 Very High Very High Very High
Death 162 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall no significant difference among the two isoforms was observed

Immunohistochemical analysis of APC expression

Gene_expression (expression) of APC associated with familial adenomatous polyposis
1) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.86 Pain Relevance 0.04
Previous studies focused on epigenetic changes of the APC promoter but did not evaluate the APC protein expression in HCC (Lee et al. 2003; Yang et al. 2003; Esteller et al. 2001; Yu et al. 2002).
Gene_expression (expression) of APC associated with hepatocellular cancer and familial adenomatous polyposis
2) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.80 Pain Relevance 0
Because promoter methylation is significantly enhanced in HCC compared to that of non-tumor samples, and APC expression is also significantly reduced in liver cancer cells, higher degrees of promoter methylation of the APC gene seem to be responsible for the reduced APC protein expression in HCC.
Gene_expression (expression) of APC in liver associated with liver cancer, cancer, familial adenomatous polyposis and hepatocellular cancer
3) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.70 Pain Relevance 0
This finding reflects the overall reduced expression of the APC protein in patients with HCC.
Gene_expression (expression) of APC associated with hepatocellular cancer and familial adenomatous polyposis
4) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 2.00 Pain Relevance 0
The levels of APC expression in cancer and non-cancer tissues (the order of the patients is identical to the panel above) were standardized to the respective beta-actin expression levels.
Gene_expression (expression) of APC associated with cancer and familial adenomatous polyposis
5) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 2.04 Pain Relevance 0.03
Using Western blot analysis, both isoforms of the APC protein were shown to be present indicating that APC protein is expressed in primary liver cancer cells.
Gene_expression (expressed) of APC in liver associated with liver cancer and familial adenomatous polyposis
6) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.96 Pain Relevance 0
Lower panel: results from reverse sequencing

Detection of APC protein expression in HCC and liver metastasis

Gene_expression (expression) of APC in liver associated with hepatocellular cancer, familial adenomatous polyposis and metastasis
7) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.40 Pain Relevance 0
The observed expression of APC in hepatocytes and tumor cells was assessed using two categories.
Gene_expression (expression) of APC in hepatocytes associated with cancer and familial adenomatous polyposis
8) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 0.48 Pain Relevance 0.03
Fig. 5a Western blot analysis of APC protein expression in three normal (N) and tumor (T) tissue samples obtained from three patients with hepatocellular carcinoma.
Gene_expression (expression) of APC associated with cancer, hepatocellular cancer and familial adenomatous polyposis
9) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.85 Pain Relevance 0
The expression of APC was similar in tumorous and non-tumorous epithelium of two patients.
Gene_expression (expression) of APC in epithelium associated with familial adenomatous polyposis
10) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.60 Pain Relevance 0.04
The APC protein was expressed both in non-tumor and tumor tissue samples obtained from patients with HCC, but values derived from our IRS were significantly lower in HCC samples compared with that of non-cancerous liver tissue samples.
Gene_expression (expressed) of APC in liver associated with cancer, hepatocellular cancer and familial adenomatous polyposis
11) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.94 Pain Relevance 0
The sizes of corresponding marker fragments are shown on the right in kilodaltons. b Quantitative analysis of APC protein expression in hepatocellular cancer.
Gene_expression (expression) of APC associated with hepatocellular cancer and familial adenomatous polyposis
12) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 2.01 Pain Relevance 0.03
Because promoter methylation is significantly enhanced in HCC compared to that of non-tumor samples, and APC expression is also significantly reduced in liver cancer cells, higher degrees of promoter methylation of the APC gene seem to be responsible for the reduced APC protein expression in HCC.
Gene_expression (expression) of APC in liver associated with liver cancer, cancer, familial adenomatous polyposis and hepatocellular cancer
13) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.91 Pain Relevance 0
Next we investigated the APC protein expression in both tumor and corresponding non-neoplastic tissue samples obtained from patients with HCC (Fig. 5).
Spec (investigated) Gene_expression (expression) of APC associated with cancer, hepatocellular cancer and familial adenomatous polyposis
14) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.51 Pain Relevance 0
In order to further evaluate subcellular expression of the APC protein, immunohistochemistry with a numerical scoring system allowing semiquantitative analysis of the expressed protein was applied.
Gene_expression (expression) of APC associated with familial adenomatous polyposis
15) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.80 Pain Relevance 0
Using Western blot analysis, both isoforms of the APC protein were shown to be present indicating that APC protein is expressed in primary liver cancer cells.
Gene_expression (expressed) of APC in liver associated with liver cancer and familial adenomatous polyposis
16) Confidence 0.78 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.79 Pain Relevance 0
Given that previous studies have detected lower levels of APC and AT III in non-survivors [34] and low endogenous PC levels and high APC:PC ratios are found in MOD patients in human SAP [6], we previously agreed to a biologically plausible rationale for the use of APC in SAP.
Gene_expression (levels) of APC associated with pancreatitis
17) Confidence 0.74 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 1.42 Pain Relevance 0.16
In severe AP, levels of PC and APC were moderately associated with monocyte activation status.
Gene_expression (levels) of APC in monocyte associated with pancreatitis
18) Confidence 0.73 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.15 Pain Relevance 0.28
The truncated or functionally inactive APC protein which can result from (1) transcriptional silencing through promoter methylation, (2) a point mutation of the APC gene or (3) loss of heterozygosity (LOH) (Hiltunen et al. 1997; Chen et al. 2005) loses the ability to interact with ?
Gene_expression (protein) of APC associated with familial adenomatous polyposis
19) Confidence 0.67 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.44 Pain Relevance 0
Methylight analysis of the APC gene
Gene_expression (analysis) of APC gene associated with familial adenomatous polyposis
20) Confidence 0.67 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 0.41 Pain Relevance 0.03

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