INT57062

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 14.30
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
colon 3
plasma 1
PGE1 1
T-cell 1
bulb 1
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 26 97.24 Very High Very High Very High
cINOD 13 96.84 Very High Very High Very High
opioid receptor 1 83.08 Quite High
Opioid 1 74.60 Quite High
psoriasis 2 66.44 Quite High
abatacept 10 50.80 Quite High
rheumatoid arthritis 32 50.16 Quite High
Inflammation 65 48.16 Quite Low
abdominal pain 5 43.04 Quite Low
methotrexate 2 41.68 Quite Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 387 100.00 Very High Very High Very High
Colon Cancer 41 100.00 Very High Very High Very High
Coagulation Disorder 6 100.00 Very High Very High Very High
Repression 2 99.76 Very High Very High Very High
Apoptosis 25 99.60 Very High Very High Very High
Syndrome 20 99.60 Very High Very High Very High
Mycobacterium Infection 86 99.46 Very High Very High Very High
Hepatocellular Cancer 153 98.96 Very High Very High Very High
Cancer 345 98.92 Very High Very High Very High
Microsatellite Instability 34 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for PC, no general dependency of APC levels with respect to the timing of the samples was observed.
Neg (no) Regulation (dependency) of APC
1) Confidence 0.58 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.08 Pain Relevance 0
Overexpression of SND1 in colon cancer cells caused down-regulation of APC and activation of the Wnt signaling pathway as a consequence, without altering APC mRNA levels.
Neg (without) Regulation (altering) of APC in colon associated with familial adenomatous polyposis and colon cancer
2) Confidence 0.52 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.00 Pain Relevance 0
We found no association of APC methylation levels and age in any of the cancer patients in either tumor or non-tumor tissues.


Neg (no) Regulation (association) of APC associated with cancer and familial adenomatous polyposis
3) Confidence 0.45 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.44 Pain Relevance 0
Finally, APC was helpful in coagulation of multiple gastric polyps (one patient, one session), hemostasis in superficial ulceration of the duodenal bulb (one patient, one session), after dilation of benign stenoses of anastomoses in the esophagus (one patient, one session) and colon (one patient, one session) and for vascular malformations in the colon (three patients, MTS 1.3), duodenum (one patient, one session), antrum (one patient, two sessions), and watermelon stomach (six patients, MTS 2.8).
Regulation (coagulation) of APC in bulb
4) Confidence 0.45 Published 1997 Journal Endoscopy Section Body Doc Link 9201466 Disease Relevance 0 Pain Relevance 0
Therefore, in our analysis, we assessed the impact of promoter methylation of APC on protein expression in HCC and non-tumor tissue samples.
Regulation (impact) of APC associated with cancer, hepatocellular cancer and familial adenomatous polyposis
5) Confidence 0.39 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 2.01 Pain Relevance 0
Mutations in the adenomatous polyposis coli (APC) gene, which initiate almost all human colon cancers, directly target the proto-oncogene, c-myc, by elevating beta-catenin/T-cell factor (TCF) signaling.
Regulation (target) of coli in T-cell associated with colon cancer and familial adenomatous polyposis
6) Confidence 0.38 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.36 Pain Relevance 0
Overexpression of SND1 in colon cancer cells caused down-regulation of APC and activation of the Wnt signaling pathway as a consequence, without altering APC mRNA levels.
Regulation (regulation) of APC in colon associated with familial adenomatous polyposis and colon cancer
7) Confidence 0.38 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 0.99 Pain Relevance 0
Mutations in the APC gene are responsible for this syndrome.
Regulation (responsible) of APC gene associated with syndrome and familial adenomatous polyposis
8) Confidence 0.32 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 2.18 Pain Relevance 0
Previous studies focused on epigenetic changes of the APC promoter but did not evaluate the APC protein expression in HCC (Lee et al. 2003; Yang et al. 2003; Esteller et al. 2001; Yu et al. 2002).
Regulation (changes) of APC associated with hepatocellular cancer and familial adenomatous polyposis
9) Confidence 0.27 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.74 Pain Relevance 0
All the other patients in the APC group received APC infusion targeted to 96 hrs with temporarily cessations for invasive procedures (range of duration 91 to 97 hrs).
Regulation (targeted) of APC
10) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 0.40 Pain Relevance 0
All values of PC levels, APC levels, and the APC/PC ratio during the hospital stay are shown in Figure 1a–c.
Regulation (values) of APC
11) Confidence 0.25 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.08 Pain Relevance 0
These findings provide preliminary results that may aid clinicians and decision makers in determining the value of APC and will also be helpful in designing evaluations of future therapies in the management of sepsis.
Spec (determining) Regulation (value) of APC associated with sepsis
12) Confidence 0.23 Published 2007 Journal Crit Care Section Body Doc Link PMC2246225 Disease Relevance 0.28 Pain Relevance 0
Loss-of-function mutations in APC or AXIN or activating mutations in the gene encoding ?
Regulation (Loss) of APC
13) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.19 Pain Relevance 0
Fecal cells including cancer cells can be assessed by analyzing DNA mutations for targets such as K-ras, p53, and adenomatous polyposis coli (APC), by analyzing epigenetic markers such as microsatellite instability (MSI), or by measuring unfragmented long-form DNA (L-DNA).
Spec (analyzing) Regulation (targets) of APC associated with cancer, familial adenomatous polyposis and microsatellite instability
14) Confidence 0.20 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.27 Pain Relevance 0.06
PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells.
Regulation (target) of APC associated with colon cancer
15) Confidence 0.19 Published 1999 Journal Cell Section Abstract Doc Link 10555149 Disease Relevance 0.51 Pain Relevance 0.27
Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.
Regulation (Effects) of APC in colons associated with apoptosis
16) Confidence 0.13 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Title Doc Link 12458338 Disease Relevance 0.29 Pain Relevance 0.10
The GS domain is also negatively regulated through the binding of FKBP12, which provides a mechanism to buffer the overall signal in the cell [8].
Regulation (regulated) of GS
17) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658887 Disease Relevance 0.41 Pain Relevance 0
On the other hand, Curvers et al. [232], used an assay that quantifies down-regulation of extrinsic coagulation by APC that is particularly sensitive to hormonal changes in women [232].
Regulation (regulation) of APC
18) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.09 Pain Relevance 0
Conversely, a pool of protective and antiprotective genes was differentially regulated in APC versus IPC (heat shock protein 27/70, programmed cell death 8), suggesting trigger-dependent transcriptome variability.
Regulation (regulated) of APC
19) Confidence 0.08 Published 2004 Journal Anesthesiology Section Body Doc Link 15108959 Disease Relevance 0 Pain Relevance 0
With respect to stimulatory receptor systems, a reciprocal regulation was observed for prostaglandin E1 (PGE1) receptors and Gs alpha, the G protein subunit activating adenylate cyclase.
Regulation (regulation) of Gs alpha in PGE1
20) Confidence 0.08 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.30 Pain Relevance 0.12

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