INT57063

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.21
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR7) signal transducer activity (HTR7)
Anatomy Link Frequency
neuronal 1
hypothalamus 1
brain 1
platelet 1
HTR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 16 99.84 Very High Very High Very High
opioid receptor 2 99.40 Very High Very High Very High
antagonist 21 99.20 Very High Very High Very High
sSRI 1 98.12 Very High Very High Very High
Sumatriptan 1 97.76 Very High Very High Very High
Endep 3 97.08 Very High Very High Very High
Opioid 2 90.32 High High
Raphe 1 73.96 Quite High
ischemia 15 52.72 Quite High
cva 3 48.88 Quite Low
Disease Link Frequency Relevance Heat
Thrombosis Related Under Development 2 96.84 Very High Very High Very High
Injury 2 96.48 Very High Very High Very High
Rheumatoid Arthritis 4 84.88 Quite High
Stroke 5 79.44 Quite High
Neuroblastoma 4 78.08 Quite High
Middle Cerebral Artery Infarction 3 76.48 Quite High
Affective Disorder 1 75.20 Quite High
Cerebral Infarction 26 53.92 Quite High
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that platelet 5-hydroxytryptamine is indeed decreased by fluoxetine, and we would predict a protective effect of fluoxetine against coronary thrombosis.
Negative_regulation (decreased) of 5-hydroxytryptamine in platelet associated with thrombosis related under development and fluoxetine
1) Confidence 0.57 Published 1996 Journal Clin. Sci. Section Abstract Doc Link 8774265 Disease Relevance 0.23 Pain Relevance 0.75
Coadministration of 5-hydroxytryptamine(1A) antagonist WAY-100635 prevents fluoxetine-induced desensitization of postsynaptic 5-hydroxytryptamine(1A) receptors in hypothalamus.
Negative_regulation (desensitization) of 5-hydroxytryptamine in hypothalamus associated with antagonist and fluoxetine
2) Confidence 0.42 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10871325 Disease Relevance 0 Pain Relevance 0.50
Recent in vitro evidence indicates that blockade of 5-hydroxytryptamine (5-HT) receptor 3 (5-HT3) is able to confer protection in different models of neuronal injury.
Negative_regulation (blockade) of 5-hydroxytryptamine in neuronal associated with injury
3) Confidence 0.42 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2259310 Disease Relevance 0.38 Pain Relevance 0.07
In contrast, messages for all 5-HT receptors tested were detected in human brain astrocytes with a predominance of the 5-HT2A and 5-HT7 subtypes.
Negative_regulation (predominance) of 5-HT7 in brain
4) Confidence 0.41 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0.18
In contrast, increased levels of inhibitory G proteins had no effect on muscarinic cholinergic receptor-mediated adenylate cyclase inhibition.
Negative_regulation (inhibition) of receptor-mediated adenylate cyclase
5) Confidence 0.06 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.30 Pain Relevance 0.12
This coordinate up-regulation is accompanied by functional changes in mu-opioid receptor-stimulated low-Km GTPase, mu-receptor-mediated adenylate cyclase inhibition, and receptor-independent guanosine 5'-(beta gamma-imido)triphosphate [Gpp(NH)p; 10 nmol/L]-mediated attenuation of adenylate cyclase activity.
Negative_regulation (inhibition) of receptor-mediated adenylate cyclase associated with opioid receptor
6) Confidence 0.05 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.30 Pain Relevance 0.14

General Comments

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