INT57064

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Context Info
Confidence 0.66
First Reported 1994
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 72
Total Number 73
Disease Relevance 48.50
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
muscle 4
plasma 3
liver 2
uterine 2
colon 1
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 88 100.00 Very High Very High Very High
Clonidine 1 99.88 Very High Very High Very High
agonist 176 99.66 Very High Very High Very High
Kinase C 23 99.42 Very High Very High Very High
Delta opioid receptors 2 98.18 Very High Very High Very High
cINOD 41 96.24 Very High Very High Very High
Inflammation 391 95.76 Very High Very High Very High
chemokine 22 95.32 Very High Very High Very High
Opioid 17 94.36 High High
addiction 15 94.08 High High
Disease Link Frequency Relevance Heat
Cancer 1312 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 871 100.00 Very High Very High Very High
Varicose Veins 167 100.00 Very High Very High Very High
Hepatitis Virus Infection 32 100.00 Very High Very High Very High
Irregular Or Premature Atrial Beats /

Premature Atrial Beats

4 100.00 Very High Very High Very High
Pelvic Organ Prolapse 10 99.98 Very High Very High Very High
Uterine Prolapse 4 99.98 Very High Very High Very High
Hepatocellular Cancer 431 99.96 Very High Very High Very High
Death 70 99.90 Very High Very High Very High
Acute Necrotizing Pancreatitis 57 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of the APC tumour-suppressor gene, and the activation of K-ras, have a combined effect on increasing tissue polyamine contents due to increased synthesis and decreased catabolism of the polyamines.
Positive_regulation (activation) of APC tumour-suppressor gene associated with cancer and familial adenomatous polyposis
1) Confidence 0.66 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.72 Pain Relevance 0.22
In children with meningococceal sepsis, on the other hand, patients' ability to generate APC in response to thrombin did not seem to be grossly affected as infusion of PC resulted in elevated levels of APC, and significant correlations were observed between APC and thrombin markers at baseline [17].
Positive_regulation (resulted) of APC associated with sepsis
2) Confidence 0.65 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.24 Pain Relevance 0
Our study detected a significant increase in serum bilirubin levels in the APC group, both in total and conjugated values.
Positive_regulation (increase) of APC
3) Confidence 0.58 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 1.13 Pain Relevance 0.04
Moreover, accumulation of the depalmitoylated form of Gs alpha in the plasma membrane as reported herein may contribute to the increase in stimulatory AC signaling, as is characteristic for the state of opioid dependence.
Positive_regulation (accumulation) of Gs alpha in plasma associated with addiction and opioid
4) Confidence 0.56 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9415709 Disease Relevance 0.26 Pain Relevance 0.55
This finding is most likely due to an increased functional activity of Gs alpha because the addition of exogenous G beta gamma subunits, which per se stimulate AC in S49cyc- membranes, failed to affect the difference in reconstitutive AC activity.
Positive_regulation (increased) of Gs alpha
5) Confidence 0.56 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9415709 Disease Relevance 0.23 Pain Relevance 0.47
Activated PC (aPC) inactivates the coagulation cofactors Va and VIIIa through proteolytic degradation, thereby limiting thrombin generation. aPC produces then anti-thrombotic, pro-fibrinolytic and anti-inflammatory activities through several different mechanisms [15].
Positive_regulation (Activated) of aPC associated with inflammation
6) Confidence 0.54 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 1.17 Pain Relevance 0.08
It was of particular interest that the methylation grade of the APC promoter was significantly enhanced in the HCC samples compared with that of the corresponding non-tumor samples.
Positive_regulation (enhanced) of APC associated with cancer, hepatocellular cancer and familial adenomatous polyposis
7) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.90 Pain Relevance 0.06
Our findings indicate that the 1A APC promoter is generally methylated in the liver suggesting that this epigenetic change is not specific for hepatocarcinogenesis and is not related to chronic hepatitis virus infection as reported in the previously published studies (Lee et al. 2003; Yang et al. 2003), because all tissue samples investigated in our study were obtained from patients with non-hepatitis virus-related HCC.
Positive_regulation (methylated) of APC in liver associated with hepatocellular cancer, familial adenomatous polyposis, hepatitis virus infection and hepatitis
8) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.63 Pain Relevance 0.08
These findings suggest that quantitative epigenetic changes are probably of clinical significance in hepatocarcinogenesis, but further post-transcriptional mechanisms must also be responsible for inactivation of the APC gene in HCC.
Positive_regulation (inactivation) of APC gene associated with hepatocellular cancer and familial adenomatous polyposis
9) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0.05
Preliminary reports suggest that the APC promoter is methylated in up to 81% of patients with viral hepatitis-induced HCC using the methylation-specific polymerase chain reaction (MSP) (Lee et al. 2003; Yang et al. 2003).
Positive_regulation (induced) of APC associated with hepatocellular cancer, familial adenomatous polyposis and hepatitis virus infection
10) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.04 Pain Relevance 0
Previous studies focused on epigenetic changes of the APC promoter but did not evaluate the APC protein expression in HCC (Lee et al. 2003; Yang et al. 2003; Esteller et al. 2001; Yu et al. 2002).
Positive_regulation (changes) of APC associated with hepatocellular cancer and familial adenomatous polyposis
11) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.74 Pain Relevance 0
Inasmuch as the APC promoter has two major promoters (1A and 1B) with five alternatively spliced 5?
Positive_regulation (has) of APC associated with familial adenomatous polyposis
12) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.06 Pain Relevance 0
In summary, APC gene mutations do not seem to play an important role in the inactivation of APC in HCC.
Positive_regulation (inactivation) of APC associated with hepatocellular cancer and familial adenomatous polyposis
13) Confidence 0.50 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0
COX-2 is a participant in the pathway of colon carcinogenesis, especially when mutation of the APC (Adenomatous Polyposis Coli) tumour suppressor gene is the initiating event.
Positive_regulation (mutation) of APC in colon associated with cancer and familial adenomatous polyposis
14) Confidence 0.49 Published 2002 Journal Biomed. Pharmacother. Section Abstract Doc Link 12199620 Disease Relevance 0.93 Pain Relevance 0.32
Therefore, in good accordance with the study by Liaw and colleagues in adult septic patients [28], we assume that the lack of elevated free APC levels in the presence of activated coagulation in patients with AP in most cases reflected dysfunctional PC activation on the endothelium, or possibly enhanced inhibition of APC by plasma protease inhibitors.
Positive_regulation (elevated) of APC in plasma associated with pancreatitis
15) Confidence 0.47 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.53 Pain Relevance 0
LV5FU2 regimen leads to a decrease in mean heart rate and a significant increase in APC and VPC which may lead to serious arrhythmias.
Positive_regulation (increase) of APC in heart associated with premature ventricular beats
16) Confidence 0.45 Published 2007 Journal Int. J. Clin. Pract. Section Abstract Doc Link 17493091 Disease Relevance 0.52 Pain Relevance 0.08
In children with meningococceal sepsis, on the other hand, patients' ability to generate APC in response to thrombin did not seem to be grossly affected as infusion of PC resulted in elevated levels of APC, and significant correlations were observed between APC and thrombin markers at baseline [17].
Positive_regulation (elevated) of APC associated with sepsis
17) Confidence 0.44 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.23 Pain Relevance 0
A more significant finding, however, may be that the APC levels seemed not to be grossly elevated.
Positive_regulation (elevated) of APC
18) Confidence 0.44 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.77 Pain Relevance 0
Of the 75 patients, 35 patients with grade III uterine prolapse underwent VTH and APC, 30 patients with grade IV uterine prolapse underwent VTH, SSS, and APC, and the other 10 patients who had previous hysterectomy with total vaginal vault prolapse underwent SSS and APC.
Positive_regulation (underwent) of APC in uterine associated with uterine prolapse and pelvic organ prolapse
19) Confidence 0.43 Published 2006 Journal Int Urogynecol J Pelvic Floor Dysfunct Section Abstract Doc Link 15965574 Disease Relevance 1.72 Pain Relevance 0.07
Inactivation of the APC protein is responsible for both inherited and sporadic types of CRC.
Positive_regulation (Inactivation) of APC associated with colorectal cancer and familial adenomatous polyposis
20) Confidence 0.42 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.43 Pain Relevance 0

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