INT57065

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Context Info
Confidence 0.22
First Reported 1994
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.43
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
muscle 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 74.32 Quite High
opioid receptor 1 69.00 Quite High
Opioid 1 60.52 Quite High
cINOD 13 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 18 99.84 Very High Very High Very High
Diabetes Mellitus 11 99.84 Very High Very High Very High
Insulin Resistance 2 97.48 Very High Very High Very High
Rheumatoid Arthritis 10 91.12 High High
Cancer 81 88.40 High High
Muscle Disease 1 79.00 Quite High
Chromosomal Instability 1 75.68 Quite High
Neuroblastoma 2 75.00 Quite High
Microvascular Angina 1 74.32 Quite High
Skin Cancer 5 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In states characterized by insulin resistance but normoglycaemia, the activity of HKII measured in needle revealed any genetic variability that contributes to explain the decreased muscle levels of GS mRNA or the decreased activity and activation of muscle GS in NIDDM patients and their glucose tolerant but insulin resistant relatives.
Negative_regulation (decreased) of Positive_regulation (activation) of GS in muscle associated with diabetes mellitus and insulin resistance
1) Confidence 0.22 Published 1999 Journal Dan Med Bull Section Abstract Doc Link 10081651 Disease Relevance 0.99 Pain Relevance 0.07
Apart from APC mutations, hypermethylation of the APC promoter at CpG sites was also detected in colorectal cancer [79], which may thus constitute an alternative mechanism for APC gene inactivation.
Negative_regulation (detected) of Positive_regulation (hypermethylation) of APC associated with colorectal cancer
2) Confidence 0.10 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.23 Pain Relevance 0
This down-regulation is paralleled by a decrease in the stimulatory activity of Gs alpha as assessed in S49 cyc- reconstitution assays.
Negative_regulation (decrease) of Positive_regulation (activity) of Gs alpha
3) Confidence 0.07 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.22 Pain Relevance 0.10

General Comments

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