INT57067

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Context Info
Confidence 0.10
First Reported 1994
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.25
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PPAP2A) plasma membrane (PPAP2A) lipid metabolic process (PPAP2A)
Anatomy Link Frequency
plasmatocytes 2
PPAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 30 100.00 Very High Very High Very High
agonist 25 100.00 Very High Very High Very High
Opioid 1 99.60 Very High Very High Very High
opioid receptor 1 94.00 High High
Clonidine 12 89.44 High High
Neuropeptide 25 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 4 92.60 High High
Neuroblastoma 2 86.96 High High
Salivary Gland Disease 37 44.64 Quite Low
Targeted Disruption 48 14.36 Low Low
Sprains And Strains 49 5.00 Very Low Very Low Very Low
Malaria 41 5.00 Very Low Very Low Very Low
Infection 27 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Stress 13 5.00 Very Low Very Low Very Low
Apoptosis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant with an enhanced expression of mu-opioid binding sites, the levels of the inhibitory G proteins Gi alpha 1 and Gi alpha 2 were found to be significantly increased.
Positive_regulation (increased) of Gene_expression (levels) of Gi alpha 2 associated with opioid
1) Confidence 0.10 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.25 Pain Relevance 0.15
Induced synthesis of proPAP 2 was detected in plasmatocytes; by immunofluorescence labeling.
Positive_regulation (Induced) of Gene_expression (synthesis) of proPAP 2 in plasmatocytes
2) Confidence 0.01 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0 Pain Relevance 0
First, in competition binding experiments at h alpha2A and h5-HT1A receptors expressed in CHO cells, several compounds, including the antagonists 1-(2-pyrimidinyl)piperazine (1-PP), (+/-)-idazoxan, benalfocin (SKF 86466), yohimbine and RX 821,002, displayed preference for h alpha2A versus h5-HT1A receptors of only 1.4-, 3.6-, 4-, 10- and 11-fold, respectively (based on differences in pKi values).
Positive_regulation (preference) of Gene_expression (expressed) of alpha2A associated with antagonist
3) Confidence 0.01 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.29
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Positive_regulation (Actions) of Gene_expression (selective) of alpha2A associated with antagonist and agonist
4) Confidence 0.01 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.31
For example, (+/-)-idazoxan was only 3.6-fold selective for h alpha2A versus h5-HT1A but 51-fold selective for r alpha2A versus r5-HT1A receptors.
Positive_regulation (selective) of Gene_expression (selective) of alpha2A
5) Confidence 0.01 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.33
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Positive_regulation (Actions) of Gene_expression (selective) of alpha2A associated with antagonist and agonist
6) Confidence 0.01 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.31

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