INT57068

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 3.76
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
dorsal horn 8
neurons 4
neuronal 2
spinal cord 2
hippocampus 2
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 104 100.00 Very High Very High Very High
Glutamate receptor 69 100.00 Very High Very High Very High
Inflammation 130 99.98 Very High Very High Very High
Spinal cord 107 99.84 Very High Very High Very High
Dorsal horn 105 99.84 Very High Very High Very High
ischemia 61 99.82 Very High Very High Very High
nMDA receptor 12 99.52 Very High Very High Very High
Eae 145 98.80 Very High Very High Very High
cerebral cortex 1 98.24 Very High Very High Very High
Nucleus accumbens 1 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 132 99.98 Very High Very High Very High
Cv Unclassified Under Development 49 99.82 Very High Very High Very High
Inflammatory Pain 140 98.80 Very High Very High Very High
Death 15 98.64 Very High Very High Very High
Syndrome 5 96.12 Very High Very High Very High
Hypersensitivity 80 89.04 High High
Stress 9 85.32 High High
Pain 35 84.48 Quite High
Leukemia 1 80.08 Quite High
Nociception 50 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further define the involvement of spinal cord AMPARs in persistent inflammatory pain, we examined whether CFA-induced inflammation produced the changes in expression of total GluR1 and GluR2 proteins in total soluble fraction derived from dorsal horn.
Regulation (changes) of Gene_expression (expression) of GluR2 in dorsal horn associated with inflammation, eae, dorsal horn and spinal cord
1) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.36 Pain Relevance 0.64
We then examined whether CFA-induced peripheral inflammation altered expression and distribution of total GluR1 and GluR2 proteins in dorsal horn.
Regulation (altered) of Gene_expression (expression) of GluR2 in dorsal horn associated with inflammation and dorsal horn
2) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.61 Pain Relevance 0.69
An unexpected observation in the current study was that CFA injection did not produce a marked change in the levels of GluR1 and GluR2 in subcellular fractions from dorsal horn at 2 h post-CFA injection.
Regulation (change) of Gene_expression (levels) of GluR2 in dorsal horn associated with dorsal horn
3) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.25 Pain Relevance 0.41
CFA-induced inflammation did not change total expression or distribution of AMPAR subunits GluR1 and GluR2 in dorsal horn but did alter their subcellular distribution.
Neg (not) Regulation (change) of Gene_expression (expression) of GluR2 in dorsal horn associated with inflammation and dorsal horn
4) Confidence 0.31 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2628655 Disease Relevance 0.55 Pain Relevance 0.52
In addition, the time course of expression of the newly synthesized GluR2 was not affected by the presence of stargazin in these cell lines.
Neg (not) Regulation (affected) of Gene_expression (expression) of GluR2
5) Confidence 0.28 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0.17 Pain Relevance 0
Consistent with this, application of the GR antagonist RU38486 (500 nM) completely blocked the corticosterone-induced increase in GluR2 surface expression and co-treatment of corticosterone with the protein synthesis inhibitor cycloheximide (100 ┬ÁM) also fully prevented the effects of corticosterone on GluR2 surface expression (Figure 1H).
Regulation (effects) of Gene_expression (expression) of GluR2 associated with antagonist
6) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0.05
Capsaicin-induced acute visceral inflammatory insult rapidly increased the amount of GluR1 protein, but not GluR2 or GluR3 proteins, in the spinal cord membrane fraction and correspondingly decreased the level of GluR1 in the cytosolic fraction, without affecting total GluR1 or GluR2 protein expression in spinal cord [9].
Neg (without) Regulation (affecting) of Gene_expression (expression) of GluR2 protein in spinal cord associated with inflammation, qutenza and spinal cord
7) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 1.18 Pain Relevance 1.20
Expression of ionotropic glutamate receptor subunits NR2A, NR2B and GluR2, and of the vesicular glutamate transporter VGLUT1 was also previously shown not to be altered by CNTF [12].
Regulation (altered) of Gene_expression (Expression) of GluR2 associated with glutamate and glutamate receptor
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.13 Pain Relevance 0.53
In contrast, ethanol did not alter the levels of glutamate receptor subunit (GLUR) 1 or GLUR2 protein, subunits that make up the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid glutamate receptor, in the hippocampus.
Neg (not) Regulation (alter) of Gene_expression (levels) of GLUR2 in hippocampus associated with glutamate receptor and hippocampus
9) Confidence 0.20 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133290 Disease Relevance 0 Pain Relevance 0.59
Our results indicate that both protein and mRNA expressions of GluR2 in cultured visual cortical neurons are tightly controlled by neuronal activity.
Regulation (controlled) of Gene_expression (expressions) of GluR2 in neuronal
10) Confidence 0.19 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.29
Neuronal activity regulates protein and gene expressions of GluR2 in postnatal rat visual cortical neurons in culture.
Regulation (regulates) of Gene_expression (expressions) of GluR2 in neurons
11) Confidence 0.19 Published 2003 Journal J. Neurocytol. Section Title Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.32
By controlling the timing of GluA2 expression using a DOX inducible expression system, a recent study showed that subunit dimers are the intermediate biosynthetic form of AMPA-Rs [23].
Regulation (controlling) of Gene_expression (expression) of GluA2
12) Confidence 0.14 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0
As an analogy to hippocampal neurons [10], we speculate that an ischemia-induced alteration of GluR2 expression in Deiter's neurons induced cell death.
Regulation (alteration) of Gene_expression (expression) of GluR2 in neurons associated with ischemia and death
13) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.51 Pain Relevance 0.19

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