INT57069

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2010
Negated 9
Speculated 3
Reported most in Body
Documents 28
Total Number 32
Disease Relevance 10.11
Pain Relevance 11.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
dorsal horn 9
amygdala 2
lamina 2
plexiform layers 1
ganglion cell layer 1
Gria2 (Rattus norvegicus)
Gria2 - L504A (1)
Pain Link Frequency Relevance Heat
Inflammation 283 100.00 Very High Very High Very High
Glutamate receptor 203 100.00 Very High Very High Very High
Dorsal horn 217 99.84 Very High Very High Very High
spinal dorsal horn 20 99.68 Very High Very High Very High
cocaine 7 99.62 Very High Very High Very High
amygdala 48 99.52 Very High Very High Very High
Spinal cord 222 99.44 Very High Very High Very High
Hippocampus 120 99.44 Very High Very High Very High
nMDA receptor 57 98.44 Very High Very High Very High
cerebral cortex 1 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 348 100.00 Very High Very High Very High
INFLAMMATION 281 100.00 Very High Very High Very High
Stress 188 99.98 Very High Very High Very High
Ganglion Cysts 20 98.52 Very High Very High Very High
Syndrome 10 96.12 Very High Very High Very High
Inflammatory Pain 280 95.72 Very High Very High Very High
Hyperglycemia 8 91.20 High High
Hypersensitivity 160 89.04 High High
Nociception 100 84.56 Quite High
Weight Loss 4 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When compared to the localization of tyrosine hydroxylase immunoreactivity, immunoreactivity for GluR1, GluR2/3 and NMDARI was mainly localized in the perikarya and proximal dendrites of the compacta neurons and only in a few reticulata neurons.
Regulation (immunoreactivity) of GluR2 in neurons
1) Confidence 0.44 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840222 Disease Relevance 0.22 Pain Relevance 0.54
Also, in diabetic human postmortem retinas we have found that GluR2 and NR1 subunits are altered, mainly at the plexiform layers and ganglion cell layer [30].
Regulation (altered) of GluR2 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
2) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.57 Pain Relevance 0.24
The effect of diabetes on the rat retinal protein levels of GluR1, GluR2, GluR2/3, and GluR4 receptor subunits was examined by western blot analysis.
Spec (examined) Regulation (effect) of GluR2 associated with diabetes mellitus
3) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.81 Pain Relevance 0.05
In contrast, ethanol did not alter the levels of glutamate receptor subunit (GLUR) 1 or GLUR2 protein, subunits that make up the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid glutamate receptor, in the hippocampus.
Neg (not) Regulation (alter) of GLUR2 in hippocampus associated with glutamate receptor and hippocampus
4) Confidence 0.34 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133290 Disease Relevance 0 Pain Relevance 0.59
CFA-induced inflammation did not change total expression or distribution of AMPAR subunits GluR1 and GluR2 in dorsal horn but did alter their subcellular distribution.
Neg (not) Regulation (change) of GluR2 in dorsal horn associated with inflammation and dorsal horn
5) Confidence 0.31 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2628655 Disease Relevance 0.55 Pain Relevance 0.52
GluR2 protein level was not affected by CFA inflammation.
Neg (not) Regulation (affected) of GluR2 associated with inflammation
6) Confidence 0.31 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17560028 Disease Relevance 0.85 Pain Relevance 0.70
In contrast, chronic cocaine treatment did not alter levels of GluR2 (an AMPA receptor subunit), NMDA2A/B (NMDA receptor subunits), or GluR6/7 (kainate receptor subunits) in this brain region.
Neg (not) Regulation (alter) of GluR2 in brain associated with nmda receptor and cocaine
7) Confidence 0.30 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.22 Pain Relevance 0.98
Consistently, slowing the desensitization by introducing GluA2 L504A (equivalent to L483A) mutation accelerates ER export and tetramerization [148].
Regulation (introducing) of GluA2 L504A (L504A)
8) Confidence 0.24 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.04
Consistent with this, corticosterone had no effect on GluR2 in the presence of a protein synthesis inhibitor.
Neg (no) Regulation (effect) of GluR2
9) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0
Rather we envisage a system in which GR activation alters genes encoding proteins involved in regulating GluR2/3 delivery and/or membrane anchoring.
Regulation (regulating) of GluR2
10) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0
Colocalization studies showed that GluR2 was present at virtually all (98%) puncta that were GluR1, GluR3, or GluR4 immunoreactive and that most (>90%) immunoreactive puncta in laminas IV, V, and IX showed GluR2, GluR3, and GluR4 immunoreactivity.
Regulation (immunoreactivity) of GluR2 in laminas
11) Confidence 0.23 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.34
Effect of CFA-induced peripheral inflammation on the levels of GluR1 and GluR2 proteins in plasma membrane fraction and cytosolic fraction from dorsal horn
Regulation (Effect) of GluR2 in dorsal horn associated with inflammation and dorsal horn
12) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.26 Pain Relevance 0.40
The entire superficial dorsal horn was delimited to quantify the optical density of GluR1 and GluR2 immunoreactivity.
Regulation (immunoreactivity) of GluR2 in dorsal horn associated with dorsal horn
13) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0 Pain Relevance 0.14
We next examined whether peripheral inflammatory insult affected the distribution of total GluR1 and GluR2 immunoreactivities in the spinal dorsal horn at 2 and 24 h after CFA injection.
Spec (whether) Regulation (immunoreactivities) of GluR2 in dorsal horn associated with inflammation and spinal dorsal horn
14) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.33 Pain Relevance 0.53
An unexpected observation in the current study was that CFA injection did not produce a marked change in the levels of GluR1 and GluR2 in subcellular fractions from dorsal horn at 2 h post-CFA injection.
Regulation (change) of GluR2 in dorsal horn associated with dorsal horn
15) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.25 Pain Relevance 0.41
This finding is inconsistent with a previous report that showed that CFA-induced peripheral inflammation increased the density of GluR1 and GluR2 immunoreactivity in dorsal horn [12].
Regulation (immunoreactivity) of GluR2 in dorsal horn associated with inflammation and dorsal horn
16) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.64 Pain Relevance 0.50
Neither intraplantar saline nor CFA produced significant changes in the distribution or optical density of GluR1 and GluR2 immunoreactivities in L4–5 spinal dorsal horn on the ipsilateral or contralateral side at 2 h (p > 0.05) or 24 h (p > 0.05) post-saline (n = 6, 3/time point) or post-CFA (n = 6, 3/time point) injection (Fig. 3D–F).


Regulation (immunoreactivities) of GluR2 in dorsal horn associated with spinal dorsal horn
17) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.34 Pain Relevance 0.49
We found that CFA injection did not affect the distribution or optical density of GluR1 and GluR2 immunoreactivity in dorsal horn.
Regulation (immunoreactivity) of GluR2 in dorsal horn associated with dorsal horn
18) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.71 Pain Relevance 0.55
The arrangement of the NTDs in the GluA2cryst tetramer was consistent with the crystal structure of the tetramers formed of the isolated GluA2 NTD [71].
Regulation (isolated) of GluA2
19) Confidence 0.21 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.04
Stress also modulated the GluA2 subunit with a decrease in the phosphorylation of both Tyr876-GluA2 and Ser880-GluA2 residues in the amygdala, and an increase in the phosphorylation of Ser880-GluA2 in the mPFC.
Regulation (modulated) of GluA2 in amygdala associated with stress and amygdala
20) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2999558 Disease Relevance 0.70 Pain Relevance 0.70

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