INT57094

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Context Info
Confidence 0.01
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) nucleus (Rtcd1) plasma membrane (Oprl1)
molecular_function (Rtcd1) ligase activity (Rtcd1) signal transducer activity (Oprl1)
Oprl1 (Mus musculus)
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Immobilon 1 99.84 Very High Very High Very High
Kappa opioid receptor 1 98.54 Very High Very High Very High
opiate 1 98.24 Very High Very High Very High
agonist 1 97.96 Very High Very High Very High
opioid receptor 4 95.64 Very High Very High Very High
Somatostatin 2 89.44 High High
medulla 1 80.12 Quite High
Spinal cord 1 75.12 Quite High
Opioid 1 73.08 Quite High
amygdala 1 72.16 Quite High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 1 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hORL1 receptor is most closely related to opioid receptors not only on structural (sequence) but also on functional grounds: hORL1 is 49-50% identical to the murine mu-, delta- and kappa-opioid receptors and, in CHO-K1 cells stably transfected with a pRc/CMV:hORL1 construct, ORL1 mediates inhibition of adenylyl cyclase by etorphine, a 'universal' (nonselective) opiate agonist.
ORL1 Positive_regulation (mediates) of Negative_regulation (inhibition) of cyclase associated with agonist, kappa opioid receptor, cytomegalovirus infection, opiate, opioid receptor and immobilon
1) Confidence 0.01 Published 1994 Journal FEBS Lett. Section Abstract Doc Link 8137918 Disease Relevance 0.10 Pain Relevance 0.71

General Comments

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