INT5710

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Context Info
Confidence 0.57
First Reported 1980
Last Reported 2010
Negated 4
Speculated 9
Reported most in Abstract
Documents 146
Total Number 159
Disease Relevance 20.51
Pain Relevance 58.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 28
plasma 8
blood 8
hypothalamus 8
gonadal 6
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 546 100.00 Very High Very High Very High
opiate 100 100.00 Very High Very High Very High
excitatory amino acid 17 100.00 Very High Very High Very High
agonist 263 99.98 Very High Very High Very High
Dopamine 255 99.98 Very High Very High Very High
antagonist 137 99.98 Very High Very High Very High
Opioid 125 99.98 Very High Very High Very High
Endogenous opioid 118 99.98 Very High Very High Very High
Morphine 57 99.98 Very High Very High Very High
Migraine 18 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 84 100.00 Very High Very High Very High
Headache 17 99.98 Very High Very High Very High
Fever 3 99.90 Very High Very High Very High
Reprotox - General 1 35 99.84 Very High Very High Very High
Stress 62 99.82 Very High Very High Very High
Migraine Without Aura 8 99.72 Very High Very High Very High
Weight Loss 1 99.72 Very High Very High Very High
Syndrome 12 99.66 Very High Very High Very High
Eating Disorder 22 99.40 Very High Very High Very High
Precocious Puberty 4 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous opioid inhibition of LH secretion is not dependent on the presence of ovarian steroids, as evidenced by the response to naloxone 3 weeks after removal of an estradiol implant from OVX lambs, when LH pulse frequency was already high.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with narcan and endogenous opioid
1) Confidence 0.57 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.76
Naloxone also increased LH pulse frequency in OVX lambs in which LH secretion was inhibited chronically by progesterone rather than by estradiol.
Negative_regulation (inhibited) of Localization (secretion) of LH associated with narcan
2) Confidence 0.57 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.06 Pain Relevance 0.78
In addition, after removal of steroid implants to allow LH secretion to increase, the degree of inhibition of LH secretion by the opiate agonist morphine was similar between age-matched postpubertal sheep and those with photoperiodically delayed puberty.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with delayed puberty, agonist, opiate and morphine
3) Confidence 0.57 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.10 Pain Relevance 0.83
Endogenous opiate peptides are considered to inhibit LH secretion via a dopaminergic mechanism, and increased opioid inhibition of LH secretion has been found in some hyperprolactinemic women with a pituitary microadenoma.
Negative_regulation (inhibition) of Localization (secretion) of LH in pituitary associated with opiate and opioid
4) Confidence 0.57 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3760121 Disease Relevance 0.07 Pain Relevance 0.75
The naloxone-induced release of LH was abolished in 9/10 calves (intact and castrated) treated with oestradiol-17 beta.
Negative_regulation (abolished) of Localization (release) of LH associated with narcan
5) Confidence 0.57 Published 1990 Journal J. Reprod. Fertil. Section Abstract Doc Link 2374132 Disease Relevance 0 Pain Relevance 0.36
Intravenous administration of the long-acting methionine-enkephalin analogue FK33-824 (250 micrograms/h for 12 h) to 3 ewes during the follicular phase of the oestrous cycle depressed episodic LH secretion.
Negative_regulation (depressed) of Localization (secretion) of LH associated with enkephalin
6) Confidence 0.56 Published 1986 Journal J. Reprod. Fertil. Section Abstract Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.66
These data suggest that opiates inhibit LH release via the combined occupancy of both mu- and kappa-receptors.
Negative_regulation (inhibit) of Localization (release) of LH associated with opiate
7) Confidence 0.56 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2831246 Disease Relevance 0.46 Pain Relevance 0.68
This study was undertaken to determine the mechanism(s) of the decreased LH secretion in these animals.
Negative_regulation (decreased) of Localization (secretion) of LH
8) Confidence 0.56 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2831246 Disease Relevance 0.39 Pain Relevance 0.35
Administration of the opiate receptor antagonist naloxone (0.5 mg/kg BW), however, not only prevented the decline, but also transiently elevated serum LH concentrations, suggesting that opiates play a role in tonic as well as stress-induced decreases in LH secretion.
Negative_regulation (decreases) of Localization (secretion) of LH associated with stress, antagonist, narcan and opiate
9) Confidence 0.56 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2831246 Disease Relevance 0.50 Pain Relevance 0.71
Numerous stressors disrupt male reproductive physiology; previous studies of a population of wild baboons, living freely in a national park in East Africa, indicated that the stress of anesthetization by phencyclidine darting decreased both LH secretion and testicular sensitivity to LH.
Negative_regulation (decreased) of Localization (secretion) of LH associated with stress
10) Confidence 0.56 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2831246 Disease Relevance 0.33 Pain Relevance 0.27
Only 5 of the 8 females responded to the same naloxone challenge in mid anestrus (June), suggesting that the contribution of opioid pathways to the inhibition of LH secretion at this time of year is not necessarily the same as that in early and late anestrus.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with narcan and opioid
11) Confidence 0.56 Published 1991 Journal Biol. Reprod. Section Abstract Doc Link 1868135 Disease Relevance 0 Pain Relevance 0.56
This study investigated whether the role of endogenous opioid peptides in the suppression of LH secretion during seasonal anestrus in the sheep changes with age.
Spec (whether) Negative_regulation (suppression) of Spec (whether) Localization (secretion) of LH associated with endogenous opioid
12) Confidence 0.56 Published 1991 Journal Biol. Reprod. Section Abstract Doc Link 1868135 Disease Relevance 0 Pain Relevance 0.29
None of the older anestrous sheep (greater than or equal to 2 yr) responded to naloxone in June, indicating age-related changes in the role of endogenous opioid mechanisms in the inhibition of LH secretion.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with endogenous opioid and narcan
13) Confidence 0.56 Published 1991 Journal Biol. Reprod. Section Abstract Doc Link 1868135 Disease Relevance 0 Pain Relevance 0.55
To determine whether an increased activity of endogenous opioid peptides causes this slowing of pulsatile LH secretion, the ability of naloxone administration to reverse the fasting-induced suppression of LH secretion was tested.
Negative_regulation (reverse) of Localization (secretion) of LH associated with narcan and endogenous opioid
14) Confidence 0.56 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475007 Disease Relevance 0.07 Pain Relevance 0.29
To determine whether the nocturnal secretion of LH in early puberty is regulated by endogenous opioid pathways, we determined whether naloxone during the night affected LH secretion or T-mediated suppression of LH secretion.
Spec (whether) Negative_regulation (suppression) of Localization (secretion) of LH associated with precocious puberty, narcan and endogenous opioid
15) Confidence 0.55 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7962287 Disease Relevance 0.10 Pain Relevance 0.27
It may be inferred from these observations that opioid-mediated inhibition of LH secretion is not altered in menstruating hyperandrogenic patients, suggesting that the circulating androgens are not an important determinant of the functional neuroendocrine activity of the opioid system.
Negative_regulation (inhibition) of Localization (secretion) of LH associated with opioid
16) Confidence 0.54 Published 1987 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 3034748 Disease Relevance 0.25 Pain Relevance 0.43
We conclude that acute administration of T suppresses LH secretion and, by inference, GnRH secretion at all stages of pubertal maturation in boys.
Negative_regulation (suppresses) of Localization (secretion) of LH
17) Confidence 0.53 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1955505 Disease Relevance 0 Pain Relevance 0.42
Through this mechanism they have been implicated in the suppression of LH secretion during the prepubertal period and the modulation of LH during the oestrous cycle.
Negative_regulation (suppression) of Localization (secretion) of LH
18) Confidence 0.53 Published 1986 Journal Res. Vet. Sci. Section Abstract Doc Link 3544108 Disease Relevance 0 Pain Relevance 0.39
It is well established that gonadal steroids suppress LH secretion by negative feedback upon the hypothalamic-pituitary axis, and this action may be brought about, in part, through intermediary opioidergic neurones.
Negative_regulation (suppress) of Localization (secretion) of LH in intermediary
19) Confidence 0.53 Published 1986 Journal Res. Vet. Sci. Section Abstract Doc Link 3544108 Disease Relevance 0 Pain Relevance 0.38
Naloxone administration during the infusion of T did not reverse the suppression of LH secretion.
Neg (not) Negative_regulation (reverse) of Localization (secretion) of LH associated with narcan
20) Confidence 0.53 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1955505 Disease Relevance 0 Pain Relevance 0.38

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