INT57101

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.14
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pzp) extracellular region (Pzp)
Anatomy Link Frequency
plasma 1
Pzp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 99.96 Very High Very High Very High
antinociception 18 99.44 Very High Very High Very High
narcan 6 99.04 Very High Very High Very High
Peripheral nerve injury 3 98.92 Very High Very High Very High
Morphine 12 97.64 Very High Very High Very High
Abeta 2 97.64 Very High Very High Very High
Inflammation 5 96.20 Very High Very High Very High
Spinal cord 6 91.72 High High
cINOD 1 89.52 High High
Neuropathic pain 1 88.80 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 5 98.48 Very High Very High Very High
Alzheimer's Dementia 1 97.20 Very High Very High Very High
INFLAMMATION 6 96.20 Very High Very High Very High
Necrosis 3 93.64 High High
Cancer 3 93.28 High High
Disease 5 91.16 High High
Neuropathic Pain 1 88.80 High High
Dementia 1 83.48 Quite High
Disorder Of Lipid Metabolism 1 75.28 Quite High
Toxicity 1 67.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, i.c.v. naltrindole inhibited both MAM- and heroin-induced antinociception, but i.t. naltrindole only inhibited the MAM response.
Negative_regulation (inhibited) of MAM associated with antinociception
1) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138935 Disease Relevance 0 Pain Relevance 1.11
Also, this MAM response was inhibited by i.t. administration of methysergide which is consistent with supraspinal mu receptor activation.
Negative_regulation (inhibited) of MAM
2) Confidence 0.37 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138935 Disease Relevance 0 Pain Relevance 0.97
MAM was decreased by coadministration of naloxone, but not naltrindole, suggesting that MAM, like morphine and heroin, acted on supraspinal mu receptors.
Negative_regulation (decreased) of MAM associated with narcan and morphine
3) Confidence 0.37 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138935 Disease Relevance 0 Pain Relevance 1.04
A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury.
Negative_regulation (derivative) of macroglobulin in plasma associated with nervous system injury, cytokine and peripheral nerve injury
4) Confidence 0.06 Published 2007 Journal J. Neurochem. Section Title Doc Link 17725582 Disease Relevance 1.03 Pain Relevance 0.59
Alpha2 macroglobulin (A2M) is a serum protease inhibitor and a major low-density lipoprotein receptor-related protein (LRP) ligand.
Negative_regulation (inhibitor) of macroglobulin
5) Confidence 0.00 Published 2004 Journal Yi Chuan Xue Bao Section Abstract Doc Link 15468911 Disease Relevance 1.10 Pain Relevance 0.23

General Comments

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