INT57104

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Context Info
Confidence 0.40
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.34
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
paw 1
Coc (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 118 100.00 Very High Very High Very High
Dopamine 23 99.56 Very High Very High Very High
ketamine 238 99.42 Very High Very High Very High
withdrawal 1 95.84 Very High Very High Very High
hypoalgesia 1 95.52 Very High Very High Very High
Pain 17 93.56 High High
antagonist 12 89.28 High High
opiate 1 88.00 High High
Neurotransmitter 1 80.40 Quite High
anticonvulsant 10 79.28 Quite High
Disease Link Frequency Relevance Heat
Premenstrual Syndrome 74 99.34 Very High Very High Very High
Hypoalagesia 1 95.52 Very High Very High Very High
Shock 1 95.12 Very High Very High Very High
Convulsion 44 94.16 High High
Anxiety Disorder 51 92.12 High High
Toxicity 10 86.68 High High
Increased Venous Pressure Under Development 1 68.88 Quite High
Stress 42 62.72 Quite High
Depression 30 61.52 Quite High
Overdose 8 58.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The end point used was shock-induced hypoalgesia (paw withdrawal from a hot plate), as we have previously shown that oscillation follows initial sensitization of this measure with one to five pretreatments of 12 mg/kg (IP) of COC spaced at 1-week intervals, with the last COC injection occurring 30 min prior to the footshock.
Positive_regulation (occurring) of COC in paw associated with shock, hypoalgesia, withdrawal and cocaine
1) Confidence 0.40 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10418787 Disease Relevance 0.19 Pain Relevance 0.63
Similar effects of COC were also noted in BA from piglets (ED50 = 0.99 +/- 0.25 x 10(-4) M) and sheep (ED50 = 1.34 +/- 0.31 x 10(-4) M).
Positive_regulation (effects) of COC associated with cocaine
2) Confidence 0.38 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138965 Disease Relevance 0.07 Pain Relevance 0.69
DA levels significantly increased after COC only and decreased after IBO administration.
Positive_regulation (increased) of COC associated with dopamine and cocaine
3) Confidence 0.37 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11085337 Disease Relevance 0 Pain Relevance 0.88
Therefore, it is possible that KT, like ethanol, a drug which increases the lethal effects of COC and for which behavioral effects similar to KT have been reported [43-45], enhances the toxic effects of psychostimulants without causing severe convulsions or painful subjective symptoms such as anxiety.


Positive_regulation (increases) of COC associated with pain, convulsion, ketamine, anxiety disorder and cocaine
4) Confidence 0.24 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1473192 Disease Relevance 0.78 Pain Relevance 0.90
In the non-fatal dose COC (30 mg/kg)-only and MA (4 mg/kg)-only groups (Fig. 1b, 1c), only at 15 min time point, hyperlocomotion was observed and activity counts were increased as compared to the control group.
Positive_regulation (increased) of COC associated with cocaine
5) Confidence 0.24 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1473192 Disease Relevance 0.11 Pain Relevance 0.72
In the same period, Yonkers and colleagues (2005) studied 450 women with symptoms of premenstrual dysphoric disorder randomized to either placebo or COC formulation containing EE 20 ?
Positive_regulation (formulation) of COC associated with premenstrual syndrome
6) Confidence 0.04 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374943 Disease Relevance 0.19 Pain Relevance 0

General Comments

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