INT5711

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 9
Speculated 6
Reported most in Abstract
Documents 90
Total Number 97
Disease Relevance 10.92
Pain Relevance 36.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 8
blood 6
pars distalis 4
POA 4
median eminence 4
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 83 100.00 Very High Very High Very High
narcan 404 99.98 Very High Very High Very High
antagonist 74 99.98 Very High Very High Very High
Neurotransmitter 22 99.98 Very High Very High Very High
Kinase C 204 99.96 Very High Very High Very High
Opioid 95 99.96 Very High Very High Very High
Central nervous system 13 99.96 Very High Very High Very High
Clonidine 13 99.92 Very High Very High Very High
withdrawal 2 99.80 Very High Very High Very High
opiate 70 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 196 100.00 Very High Very High Very High
Opiate Addiction 1 99.80 Very High Very High Very High
Headache 7 99.62 Very High Very High Very High
Reprotox - General 1 18 99.48 Very High Very High Very High
Galactorrhea 13 98.94 Very High Very High Very High
Weight Loss 2 98.88 Very High Very High Very High
Eating Disorder 19 98.64 Very High Very High Very High
Anovulation 2 96.40 Very High Very High Very High
Death 21 95.76 Very High Very High Very High
Body Weight 13 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LHRH infusion induced a biphasic release of LH in intact animals of both sexes and in castrated females but not in castrated males.
Positive_regulation (induced) of Localization (release) of LH
1) Confidence 0.70 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.14
However, changes in opioid inhibition are unlikely to underlie the decrease in sensitivity to steroid negative feedback and increase in pulsatile LH secretion that occur at puberty.
Positive_regulation (increase) of Localization (secretion) of LH associated with opioid
2) Confidence 0.68 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.09 Pain Relevance 0.65
Naloxone treatment (hourly iv injections of 1 mg/kg BW for 4 h) produced an increase in the frequency of episodic LH secretion at all prepubertal ages, when lambs were highly sensitive to the estradiol negative feedback.
Positive_regulation (increase) of Localization (secretion) of LH associated with narcan
3) Confidence 0.68 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.61
However, increases in LH pulse frequency were also induced by naloxone treatment at a postpubertal age in estradiol-treated OVX sheep, indicating that opioid inhibition is still present at a time when sensitivity to the feedback effects of ovarian steroids is markedly reduced and endogenous LH secretion is increased.
Positive_regulation (increased) of Localization (secretion) of LH associated with narcan and opioid
4) Confidence 0.68 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.74
Treatment of ovary-intact prepubertal sheep at 12 weeks of age with the opiate antagonist naloxone resulted in a dose-dependent increase in LH secretion.
Positive_regulation (increase) of Localization (secretion) of LH in ovary associated with antagonist, narcan and opiate
5) Confidence 0.68 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.49
Although neither opioid antagonist stimulated LH release when administered alone, each significantly potentiated the LH response to NMA in young adult (10- to 14-week-old) male mice (p < 0.01) but not in older (10- to 16-month-old) male mice.
Neg (neither) Positive_regulation (stimulated) of Localization (release) of LH associated with antagonist and opioid
6) Confidence 0.67 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8159277 Disease Relevance 0 Pain Relevance 0.83
Although the opioid antagonist naloxone (NAL) induces LH secretion in many species, there are no reports of an effect of NAL on LH release in mice.
Positive_regulation (induces) of Localization (secretion) of LH associated with antagonist, narcan and opioid
7) Confidence 0.67 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8159277 Disease Relevance 0 Pain Relevance 0.62
The naloxone-induced release of LH was abolished in 9/10 calves (intact and castrated) treated with oestradiol-17 beta.
Positive_regulation (induced) of Localization (release) of LH associated with narcan
8) Confidence 0.67 Published 1990 Journal J. Reprod. Fertil. Section Abstract Doc Link 2374132 Disease Relevance 0 Pain Relevance 0.36
Naloxone (25 mg/h for 12 h) administered alone to 3 ewes in the follicular phase also enhanced LH secretion.
Positive_regulation (enhanced) of Localization (secretion) of LH associated with narcan
9) Confidence 0.67 Published 1986 Journal J. Reprod. Fertil. Section Abstract Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.72
This effect was reversed by administration of the opiate antagonist naloxone (25 mg/h) in combination with the FK33-824 treatment; in fact LH secretion was enhanced by the combined regimen.
Positive_regulation (enhanced) of Localization (secretion) of LH associated with antagonist, narcan and opiate
10) Confidence 0.67 Published 1986 Journal J. Reprod. Fertil. Section Abstract Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.73
These results suggest that ovarian steroids can stimulate LH release in the immature female guinea pig, but not until an age approaching the normal time of the first ovulation.
Neg (not) Positive_regulation (stimulate) of Localization (release) of LH
11) Confidence 0.66 Published 1984 Journal Endocrinology Section Abstract Doc Link 6734515 Disease Relevance 0 Pain Relevance 0.09
The nocturnal augmentation of LH secretion was suppressed by the infusion of T, and this suppression was not reversed by naloxone.
Positive_regulation (augmentation) of Localization (secretion) of LH associated with narcan
12) Confidence 0.65 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7962287 Disease Relevance 0.06 Pain Relevance 0.31
NMA challenges significantly stimulated LH secretion in 10 of 11 HPG/POA females.
Positive_regulation (stimulated) of Localization (secretion) of LH in POA
13) Confidence 0.64 Published 1995 Journal Biol. Reprod. Section Abstract Doc Link 7756451 Disease Relevance 0 Pain Relevance 0.49
Mean LH and LH pulse frequency were suppressed (P less than 0.01), and the sleep-associated increase in LH secretion was abolished.
Positive_regulation (increase) of Localization (secretion) of LH
14) Confidence 0.63 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1955505 Disease Relevance 0 Pain Relevance 0.34
These negative feedback effects, however, cannot be reversed by coadministration of naloxone, even in mid- to late pubertal boys who respond to naloxone with increased pulsatile secretion of LH.
Positive_regulation (increased) of Localization (secretion) of LH associated with narcan
15) Confidence 0.63 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1955505 Disease Relevance 0 Pain Relevance 0.40
In contrast, the same dose of naloxone failed to stimulate LH secretion in monkeys restrained in primate chairs.
Neg (failed) Positive_regulation (stimulate) of Localization (secretion) of LH associated with narcan
16) Confidence 0.60 Published 1983 Journal Endocrinology Section Abstract Doc Link 6414806 Disease Relevance 0 Pain Relevance 0.55
We conclude from these results that the ability of naloxone to stimulate LH secretion is limited to the luteal phase.
Positive_regulation (stimulate) of Localization (secretion) of LH associated with narcan
17) Confidence 0.60 Published 1983 Journal Endocrinology Section Abstract Doc Link 6414806 Disease Relevance 0 Pain Relevance 0.41
In these mice, plasma LH concentrations were reduced (p < 0.05), and GH treatment increased (p < 0.01) LH secretion.
Positive_regulation (increased) of Localization (secretion) of LH in plasma
18) Confidence 0.56 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8722619 Disease Relevance 0.47 Pain Relevance 0.05
With Nx treatment of the restrained animals, both ACTH and cortisol were elevated as in the controls and LH and testosterone secretion were significantly increased within 1-2 h.
Positive_regulation (increased) of Localization (secretion) of LH associated with narcan
19) Confidence 0.56 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1314338 Disease Relevance 0.07 Pain Relevance 0.53
In addition, after removal of steroid implants to allow LH secretion to increase, the degree of inhibition of LH secretion by the opiate agonist morphine was similar between age-matched postpubertal sheep and those with photoperiodically delayed puberty.
Positive_regulation (allow) of Localization (secretion) of LH associated with delayed puberty, agonist, opiate and morphine
20) Confidence 0.49 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.09 Pain Relevance 0.85

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